Cardiovascular Prostheses

Abstract

Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from a cellular extracellular matrix (ECM). The cardiovascular prostheses comprise mesh structures comprising poly(glycerol sebacate) (PGS) and various antibiotics.

What is claimed is: 
     
         1 . A prosthesis for treating damaged biological tissue, comprising:
 a mesh structure comprising a plurality of fibers comprising an extracellular matrix (ECM) composition comprising acellular ECM from a mammalian tissue source and at least one antibiotic selected from the group consisting of vancomycin and gentamicin,   each of said plurality of fibers comprising an outer surface,   said plurality of ECM fibers comprising a coating disposed on said outer surface, said coating comprising a composition comprising poly(glycerol sebacate) (PGS).   
     
     
         2 . The prosthesis of  claim 1 , wherein said mammalian tissue source comprises tissue selected from the group consisting of small intestine submucosa (SIS), urinary bladder submucosa (UBS), stomach submucosa (SS), mesothelial tissue, placental tissue, cardiac tissue, kidney tissue and omentum tissue. 
     
     
         3 . A prosthesis for treating damaged biological tissue, comprising:
 a mesh structure comprising a plurality of fibers comprising a composition comprising acellular ECM from a mammalian tissue source, poly(glycerol sebacate) (PGS) and at least one antibiotic selected from the group consisting of vancomycin and gentamicin.   
     
     
         4 . The prosthesis of  claim 3 , wherein said mammalian tissue source comprises tissue selected from the group consisting of small intestine submucosa (SIS), urinary bladder submucosa (UBS), stomach submucosa (SS), mesothelial tissue, placental tissue, cardiac tissue, kidney tissue and omentum tissue.