Bioactive bone graft substitutes

Abstract

Provided are synthetic bone graft substitutes that include bioactive glass and a carrier. Synthetic bone graft substitutes may include bioactive glass, glycerol and polyethylene glycol. Also provided are bone graft substitutes that include collagen and bioactive glass particles. Example bone graft substitutes may include collagen and bioactive glass particles. Other example embodiments may include Type I Bovine Collagen, an angiogenic agent, such as hyaluronic acid, and bioactive glass. Further provided are methods that include administering the present bone graft substitutes to a mammal, e.g., by surgical insertion of the bone graft substitute into the mammal, either alone or in conjunction with one or more implant devices. Further provided are kits that include the present bone grafts.

What is claimed is: 
     
         1 . A bone graft substitute comprising:
 about 71% or more by weight of bioactive glass;   glycerol; and   polyethylene glycol.   
     
     
         2 . The bone graft substitute of  claim 1 , comprising about 71% to about 75% by weight of 45S5 bioactive glass, about 15% to about 19% by weight of glycerol, and about 10% to about 14% by weight of polyethylene glycol. 
     
     
         3 . The bone graft substitute of  claim 1 , comprising about 71% by weight of 45S5 bioactive glass, about 17% by weight of glycerol, and about 12% by weight of polyethylene glycol 2000. 
     
     
         4 . The bone graft substitute of  claim 1 , wherein said bone graft is in the form of a soft moldable putty. 
     
     
         5 . An implant comprising the bone graft substitute of  claim 1 . 
     
     
         6 . A bone graft substitute comprising:
 less than about 67% by weight of bioactive glass,   glycerol; and   polyethylene glycol.   
     
     
         7 . The bone graft substitute of  claim 6 , comprising about 53% to about 57% by weight of 45S5 bioactive glass particles, about 18% to about 22% by weight of glycerol, and about 23% to about 27% by weight of polyethylene glycol. 
     
     
         8 . The bone graft substitute of  claim 7 , comprising about 55% by weight of 45S5 bioactive glass, about 20% by weight of glycerol, and about 25% by weight of polyethylene glycol. 
     
     
         9 . The bone graft substitute of  claim 6 , comprising about 48% to about 52% by weight of 45S5 bioactive glass, about 13% to about 17% by weight of glycerol, and about 33% to about 37% by weight of polyethylene glycol. 
     
     
         10 . The bone graft substitute of  claim 9 , comprising about 50% by weight of 45S5 bioactive glass, about 15% by weight of glycerol, and about 35% by weight of polyethylene glycol. 
     
     
         11 . The bone graft substitute of  claim 6 , wherein said bone graft substitute is in a form selected from the group consisting of a soft moldable putty, a powder that may be reconstituted to form a soft moldable putty, a flowable extrudable gel and a crunch form. 
     
     
         12 . An implant comprising the bone graft substitute of  claim 6 . 
     
     
         13 . A bone graft substitute comprising at least about 15% by weight of collagen and at least about 75% by weight of bioactive glass particles. 
     
     
         14 . The bone graft substitute of  claim 13 , comprising about 17-23% by weight of collagen, and about 77-83% by weight bioactive glass particles. 
     
     
         15 . The bone graft substitute of  claim 13 , wherein said bone graft substitute is in a form selected from the group consisting of a scaffold, strip and putty/pack. 
     
     
         16 . An implant comprising the bone graft substitute of  claim 13 . 
     
     
         17 . A bone graft substitute comprising bioactive glass, hyaluronic acid and glycerol. 
     
     
         18 . The bone graft substitute of  claim 17 , comprising about 70% to about 76% by weight of bioactive glass, about 1-3% by weight of hyaluronic acid, and about 22% to about 28% by weight glycerol. 
     
     
         19 . The bone graft substitute of  claim 17 , comprising about 59% to about 66% by weight of bioactive glass, about 1% to about 4% by weight of hyaluronic acid, and about 31% to about 39% by weight glycerol. 
     
     
         20 . The bone graft substitute of  claim 17 , comprising about 54% to about 60% by weight of bioactive glass, about 5-7% by weight of hyaluronic acid, and about 34% to about 40% by weight glycerol.