Rotational spun material covered medical appliances and methods of manufacture

Abstract

A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.

1 . A medical appliance, comprising:
 a first layer of polytetrafluoroethylene (PTFE);   a tie layer coupled to the first layer, wherein the tie layer is impervious to cell migration into the tie layer; and   a second layer.   
     
     
         2 . The medical appliance of  claim 1 , wherein the first layer comprises serially deposited PTFE fibers deposited in the absence of an electric field. 
     
     
         3 . The medical appliance of  claim 1 , wherein the first layer comprises rotational spun PTFE fibers deposited in the absence of an electric field. 
     
     
         4 . The medical appliance of  claim 1 , wherein the first layer defines a luminal surface of the medical appliance. 
     
     
         5 . The medical appliance of  claim 1 , wherein the tie layer comprises fluorinated ethylene propylene (FEP). 
     
     
         6 . The medical appliance of  claim 1 , wherein the tie layer is non-porous and non-fibrous. 
     
     
         7 . The medical appliance of  claim 1 , wherein the second layer comprises PTFE. 
     
     
         8 . The medical appliance of  claim 1 , wherein the second layer comprises expanded polytetrafluoroethylene (ePTFE). 
     
     
         9 . A medical appliance, comprising:
 a first layer of rotational spun PTFE fibers;   a tie layer of FEP coupled to the first layer; and   a second layer.   
     
     
         10 . The medical appliance of  claim 9 , wherein the first layer defines a luminal surface of the medical appliance. 
     
     
         11 . The medical appliance of  claim 9 , wherein the rotational spun PTFE fibers are deposited in the absence of an electric field. 
     
     
         12 . The medical appliance of  claim 9 , wherein the tie layer is impervious to cell migration into the tie layer. 
     
     
         13 . The medical appliance of  claim 9 , wherein the tie layer is non-porous and non-fibrous. 
     
     
         14 . The medical appliance of  claim 9 , wherein the second layer comprises ePTFE. 
     
     
         15 . A medical appliance, comprising:
 a first layer of PTFE;   a non-porous and non-fibrous tie layer coupled to the first layer; and   a second layer of ePTFE.   
     
     
         16 . The medical appliance of  claim 15 , wherein the first layer comprises serially deposited PTFE fibers deposited in the absence of an electric field. 
     
     
         17 . The medical appliance of  claim 15 , wherein the first layer comprises rotational spun PTFE fibers deposited in the absence of an electric field. 
     
     
         18 . The medical appliance of  claim 15 , wherein the first layer defines a luminal surface of the medical appliance. 
     
     
         19 . The medical appliance of  claim 15 , wherein the tie layer comprises FEP. 
     
     
         20 . The medical appliance of  claim 15 , wherein the tie layer is impervious to cell migration into the tie layer.