Polymeric material for accommodating intraocular lenses

Abstract

The disclosure relates generally to a polymeric material for use in accommodating intraocular lenses for implantation in a lens chamber of a subject's eye. The present disclosure is directed to a polymeric material which comprises a fluorosilicone polymer and a silica component. The presently disclosed polymeric material is both optically clear and has a sufficiently low Young's modulus such that it can effectively respond to the eye's natural accommodative forces and thus can be used in accommodating intraocular lenses. When used in the fabrication of an intraocular lenses, the polymeric material disclosed herein protect the physical characteristics of the lens as the added hydrophobicity of the fluorosilicone polymer allows it to effectively resist diffusion of fluid from the eye and the adhesion of biologica materials.

1 . (canceled) 
     
     
         2 . A fluorosilicone base composition comprising:
 a fluorosilicone polymer; and   up to about 30 weight % of a silanized fumed silica component,   wherein the silanized fumed silica component has a surface area of at least about 280 m 2 /g; and   wherein the fluorosilicone polymer comprises a polymer of formula (II):   
       
         
           
           
               
               
           
         
         wherein: 
         n and m are each independently 0 to about 500; 
         t is about 100 to about 1000; 
         each R 1  is independently alkyl or aryl; 
         R 2  is haloalkyl; 
         R 3  is alkyl or haloalkyl; and 
         R 4  and R 5  are aryl. 
       
     
     
         3 . The fluorosilicone base composition of  claim 2 , wherein the silanized fumed silica component has a surface area of from about 280 m 2 /gram to about 350 m 2 /g. 
     
     
         4 . The fluorosilicone base composition of  claim 2 , comprising about 20% to about 27% of the silanized fumed silica component. 
     
     
         5 . The fluorosilicone base composition of  claim 2 , wherein R 2  is 3,3,3-trifluoropropyl. 
     
     
         6 . The fluorosilicone base composition of  claim 5 , comprising at least about 25 mole % trifluoropropyl content. 
     
     
         7 . A method of making a crosslinked polymeric material, comprising the steps of:
 (a) adding a crosslinking agent and a curing agent to the fluorosilicone base composition of  claim 2 ; and   (b) curing the fluorosilicone base composition to obtain the cross linked polymeric material.   
     
     
         8 . The method of  claim 7 , wherein step (a) comprises:
 adding the crosslinking agent to a first portion of the fluorosilicone base composition, and adding the curing agent to a second portion of the fluorosilicone base composition, and   mixing the first and second portions prior to step (b).   
     
     
         9 . The method of  claim 8 , wherein the first portion of the fluorosilicone base composition further comprises an inhibitor. 
     
     
         10 . The method of  claim 7 , wherein the curing agent is a platinum catalyst. 
     
     
         11 . The method of  claim 7 , wherein the silanized fumed silica component has a surface area of from about 280 m 2 /g to about 350 m 2 /g. 
     
     
         12 . The method of  claim 7 , wherein the crosslinking agent is a methylhydrosiloxane-dimethylsiloxane copolymer. 
     
     
         13 . The method of  claim 12 , wherein the crosslinking agent has a chain length of from about 5 to about 30 repeating Si units. 
     
     
         14 . The method of  claim 7 , wherein R 2  is 3,3,3-trifluoropropyl. 
     
     
         15 . An intraocular lens comprising a crosslinked polymeric material made according to the method of  claim 7 . 
     
     
         16 . The intraocular lens of  claim 15 , wherein the crosslinked polymeric material has a refractive index of from about 1.35 to about 1.40. 
     
     
         17 . The intraocular lens of  claim 15 , wherein the crosslinked polymeric material has a percent elongation of from about 400% to about 1000%. 
     
     
         18 . The intraocular lens of  claim 15 , wherein the crosslinked polymeric material has a Young's modulus of from about 10 psi to about 150 psi. 
     
     
         19 . The intraocular lens of  claim 15 , wherein the crosslinked polymeric material has a Young's modulus from about 50 psi to about 100 psi. 
     
     
         20 . An intraocular lens (IOL) device comprising:
 (a) a first lens comprised of the crosslinked polymeric material made by the method of  claim 7  having a first Young's modulus;   (b) a second lens in spaced relation to the first lens along a central optical axis; and   (c) a circumferential portion encircling the first and second lens, the circumferential portion comprising an outer peripheral edge;   wherein at least one of a portion of the second lens and a portion of the circumferential portion is made of a material having a second Young's modulus; and   wherein the first Young's modulus is less than the second Young's modulus.