US2020383326A1PendingUtilityA1
Cleanser compositions and methods for using the same
Est. expiryMay 1, 2029(~2.8 yrs left)· nominal 20-yr term from priority
A61K 8/342Y02A50/30A61K 31/4166A61P 17/02A61P 17/00A61K 31/122A61P 17/10A61K 31/045A01N 31/02A01N 35/06A61K 8/35A61Q 17/005A61K 8/345A01N 25/08A61P 31/04A61P 27/02A61P 17/08A61K 36/61A61P 31/10
70
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Claims
Abstract
The present invention is directed to anti-microbial cleanser compositions comprising linalool, hinokitiol and dipropylene glycol . The present invention further provides methods for using these compositions to maintain eyelid hygiene, to treat an ocular disorder or to clean a skin surface. The cleanser compositions of the present invention can be in the form of a foam, gel or liquid.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A cleanser composition suitable for application to the skin and ocular surface comprising linalool, hinokitiol and an alcohol.
2 . The cleanser composition of claim 1 , wherein the alcohol is a diol.
3 . The cleanser composition of 2 , wherein the diol is a glycol.
4 . The cleanser composition of claim 3 , wherein the glycol is selected from the group consisting of propylene glycol, and ethylene glycol and dipropylene glycol.
5 . The cleanser composition of claim 1 , further comprising decyl glucoside, sodium trideceth sulfate, cocamidopropyl betaine, dipropylene glycol or mixtures thereof.
6 . The cleanser composition of claim 1 , wherein the cleanser composition is suitable for direct application to the ocular surface, an eyelid or the skin surrounding the eyelid of a subject.
7 . The cleanser composition of claim 1 , wherein the cleanser composition is a applied as a foam, gel or liquid.
8 . The cleanser composition of claim 1 , wherein the composition is for the treatment of an ocular disorder.
9 . The cleanser composition of claim 8 , wherein the ocular disorder is selected from the group consisting of dry eye, excessive bacteria on the eyelid dermis, Meibomian gland dysfunction (MGD), blepharitis, acne rosacea, scalp dandruff, seborrheic dermatitis, chalazion, hordeolum, sty infectious conjunctivitis, corneal ulcer, demodex infestation, and any combination thereof.
10 . The cleanser composition of claim 1 , wherein the ocular disorder is anterior or posterior blepharatis.
11 . The cleanser composition of claim 1 , wherein the composition is effective against at least one of the following microorganisms: S. aureus, P. aeruginosa, B. catarrhalis, E. coli, S. marcescens, S. epidermidis , MRSA, and P. ovale.
12 . The cleanser composition of claim 11 , wherein the S. aureus is methicillin resistant S. aureus.
13 . The cleanser composition of claim 1 , wherein the cleanser comprises the following components in approximately the following concentrations as a percent by weight:
(a)
Coladet BSB
0.5-10.0%;
(b)
Decyl Glucoside
0.2-10.0%;
(c)
Linalool
0.5-2.0%;
(d)
Cocamidopropyl PG-Dimonium
0.01-5.0%;
Choloride Phosphate
(e)
Trisodium EDTA
0.01-1.0%;
(f)
Allantoin
0.01-1.0%;
(g)
Panthenol
0.01-1.0%;
(h)
Hinokitiol
0.01-5.0%;
(i)
Tea Tree Oil
0.005-2.0%;
(j)
Vitamin E Acetate
0.005-2.0%;
(k)
Watcr
0.0-98.15%;
(l)
Dipropylene glycol
1.0-50.0%; and
(m)
Cocamidopropyl bctainc
0.1-20.0%.
14 . The cleanser composition of claim 9 , wherein the cleanser comprises the following components in approximately the following amounts as a percent by weight:
(a)
Coladet BSB
3.8%;
(b)
Decyl Glucoside
1.7%
(c)
Linalool
0.9%;
(d)
Cocamidoproply PG-Dimonium
0.2%;
Choloride Phosphate
(e)
Trisodium EDTA
0.1%;
(f)
Allantoin
0.1%;
(g)
Panthenol
0.1%
(h)
Hinokitiol
0.05%;
(i)
Tea Tree Oil
0.025%;
(j)
Vitamin E Acetate
0.01%;
(k)
Water
68.215%;
(l)
Dipropylene glycol
23.0%; and
(m)
Cocamidopropyl betaine
2.0%.
15 . The cleanser composition of claim 1 , wherein the pH range is about 4.5-6.0.
16 . The cleanser composition of claim 1 , wherein the pH range is about 5.3-5.7.
17 . A ophthalmologically acceptable cleanser composition comprising linalool, hinkokitiol and cocamidopropyl PG-dimonium chloride phosphate.
18 . A method of cleaning a body surface of a subject comprising:
applying the a cleanser composition set forth in claim 1 to the body surface; thereby cleaning the surface.
19 . The method of claim 18 , wherein the composition is in the form of a foam, gel or liquid.
20 . The method of claim 18 , wherein the surface is an eyelid.
21 . The method of claim 18 , wherein the cleanser composition is formulated such that upon application to the body surface or eyelid the cleanser composition does not substantially damage or irritate the body surface or eyelid.
22 . A method of treating ocular disorder in a subject comprising the steps of:
applying the cleanser composition to the of claim 1 to an eye lid; thereby treating an ocular disorder.
23 . The method of claim 22 , further comprising cleansing the eyelid by localized and sustained massaging of the composition.
24 . The method of claim 22 , wherein the ocular disorder is selected from the group consisting of dry eye, excessive bacterial colonization on the eyelid, Meibomian gland dysfunction (MGD), blepharitis, acne rosacea, scalp dandruff, seborrheic dermatitis, chalazion, hordeolum, sty, infectious conjunctivitis, corneal ulcer, demodex infestation and any combination thereof.
25 . The method of claim 24 , wherein the ocular disorder is anterior blepharatis or posterior blepharitis.
26 . A method of treating a subject having a demodex infestation, comprising the steps of:
applying a cleanser composition set forth in claim 1 to the eye lid; thereby treating a demodex infestation.
27 . The method of claim 26 , wherein the cleanser composition is the cleanser composition set forth in claim 14 .
28 . A kit for maintaining eyelid hygiene in a subject comprising the cleanser composition of claim 1 and instructions for use.
29 . The kit of claim 28 , further comprising an applicator.
30 . The kit of claim 29 , wherein the applicator is a sponge.Cited by (0)
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