Pain reliever composition

Abstract

An inventive composition including an amount of sugar or sugar alcohol, an amount of alkalizing agent, and an amount of vehicle; whereby the inventive composition is formulated for transdermal administration to alleviate one or more disorder symptoms, for example neurogenic pain, or to treat one or more disorders, for example neurogenic inflammation.

1 . A composition comprising:
 an amount of sugar or sugar alcohol;   an amount of alkalizing agent; and   an amount of vehicle;   wherein said composition is formulated for transdermal administration.   
     
     
         2 . The composition of  claim 1 , wherein said amount of sugar or sugar alcohol is in a range of between about 2% to about 30% by weight of said composition. 
     
     
         3 . The composition of  claim 2 , wherein said amount of sugar or sugar alcohol is in a range selected from the group consisting of: between about 5% to about 30% by weight of said composition; between about 10% to about 30% by weight of said composition; between about 15% to about 30% by weight of said composition; and between about 20% to about 30% by weight of said composition. 
     
     
         4 . The composition of  claim 2 , wherein said sugar is one or more selected from the group consisting of: ribose, xylose, fructose, dextrose, galactose, mannose, sorbose, sucrose, maltose, lactose, lactulose, trehalose, and cellobiose. 
     
     
         5 . The composition of  claim 2 , wherein said sugar comprises dextrose. 
     
     
         6 . The composition of  claim 2 , wherein said sugar alcohol is one or more selected from the group consisting of: glycerol, erythritol, threitol, arabitol, xylitol, adonitol, mannitol, sorbitol, dulcitol, fucitol, iditol, inositol, volemitol, isomalt, maltitol, lactitol, and maltotriitol. 
     
     
         7 . The composition of  claim 2 , wherein said sugar alcohol comprises mannitol. 
     
     
         8 . The composition of  claim 2 , wherein said amount of alkalizing agent is in a range of between about 0.1% to about 15% by weight of said composition. 
     
     
         9 . The composition of  claim 8 , wherein said amount of alkalizing agent is in a range of between about 6.5% to about 15% by weight of said composition. 
     
     
         10 . The composition of  claim 8 , wherein said alkalizing agent is one or more selected from the group consisting of: sodium bicarbonate, potassium citrate, calcium carbonate, and calcium acetate. 
     
     
         11 . The composition of  claim 8 , wherein said alkalizing agent comprises sodium bicarbonate. 
     
     
         12 . The composition of  claim 8 , wherein said alkalizing agent comprises a salt. 
     
     
         13 . The composition of  claim 12 , wherein said salt comprises a cation selected from the group consisting of: sodium, calcium, potassium, zinc, iron, and magnesium. 
     
     
         14 . The composition of  claim 12 , wherein said salt comprises an anion selected from the group consisting of: chloride, acetate, ascorbate, bicarbonate, citrate, formate, fumarate, phosphate, succinate, borate, gluconate, lactate, malate, trimalate, panthothenate, thiocyanate, glycinate, and sulphate. 
     
     
         15 . The composition of  claim 12 , wherein said salt is selected from the group consisting of: sodium chloride, sodium acetate, sodium bicarbonate, sodium citrate, sodium phosphate, sodium dihydrogen phosphate, sodium hydrogen phosphate, sodium succinate, sodium borate, sodium gluconate, sodium citrate, sodium lactate, calcium citrate, calcium chloride, calcium pantothenate, calcium gluconate, calcium phosphate, potassium chloride, monopotassium phosphate, dipotassium phosphate, tripotassium phosphate, potassium gluconate, magnesium sulphate, magnesium chloride, magnesium gluconate, magnesium acetate, magnesium malate, magnesium glycinate, magnesium lactate, zinc chloride, zinc sulphate and zinc acetate. 
     
     
         16 . The composition of  claim 8 , wherein said amount of sugar or sugar alcohol is solubilized in said vehicle. 
     
     
         17 . The composition of  claim 8 , wherein said amount of sugar or sugar alcohol is suspended in said vehicle. 
     
     
         18 . The composition of  claim 8 , wherein said vehicle facilitates said transdermal administration of a portion of said amount sugar or sugar alcohol and a portion of said amount of alkalizing agent. 
     
     
         19 . The composition of  claim 18 , wherein said vehicle comprises an emulsion base. 
     
     
         20 . The composition of  claim 19 , wherein said emulsion base comprises an oil selected from the group consisting of: vegetable oils, animal oils, mineral oils, silicone oils, synthetic oils, fatty acids, fatty alcohols, phospholipids, and paraffin waxes. 
     
     
         21 .- 60 . (canceled)