Formulations of rifaximin and uses thereof

Abstract

The present invention relates to new rifaximin forms comprising solid dispersions of rifaximin, methods of making same and to their use in medicinal preparations and therapeutic methods.

1 - 12 . (canceled) 
     
     
         13 . A method of treating a bowel related disorder in a subject in need thereof, comprising administering to the subject a solid dispersion comprising rifaximin and a polymer, wherein the polymer comprises from about 10% to about 60% by weight of the solid dispersion and is selected from the group consisting of polyvinylpyrrolidone (PVP) grade K-90, hydroxypropylmethyl cellulose phthalate (HPMC-P) grade 55, hydroxypropyl methylcellulose acetate succinate (HPMC-AS) grades HG and MG, and polymethacrylate, and wherein said solid dispersion comprises a non-crystalline fully miscible dispersion comprising said rifaximin and said polymer. 
     
     
         14 . The method of  claim 13 , wherein the bowel related disorder is irritable bowel syndrome. 
     
     
         15 . The method of  claim 13 , wherein the bowel related disorder is hepatic encephalopathy. 
     
     
         16 . The solid dispersion of  claim 13 , wherein said rifaximin and said polymer are present in equal amounts, and each of said rifaximin and said polymer comprises from about 10% to about 50% by weight of said solid dispersion. 
     
     
         17 . The solid dispersion of  claim 14 , wherein said rifaximin and said polymer are present in equal amounts, and each of said rifaximin and said polymer comprises from about 10% to about 50% by weight of said solid dispersion. 
     
     
         18 . The solid dispersion of  claim 15 , wherein said rifaximin and said polymer are present in equal amounts, and each of said rifaximin and said polymer comprises from about 10% to about 50% by weight of said solid dispersion. 
     
     
         19 . The solid dispersion of  claim 13 , wherein said polymer comprises HPMC-AS grade MG or HPMC-AS grade HG. 
     
     
         20 . The solid dispersion of  claim 14 , wherein said polymer comprises HPMC-AS grade MG or HPMC-AS grade HG. 
     
     
         21 . The solid dispersion of  claim 15 , wherein said polymer comprises HPMC-AS grade MG or HPMC-AS grade HG. 
     
     
         22 . The solid dispersion of  claim 16 , wherein said polymer comprises HPMC-AS grade MG or HPMC-AS grade HG. 
     
     
         23 . The solid dispersion of  claim 17 , wherein said polymer comprises HPMC-AS grade MG or HPMC-AS grade HG. 
     
     
         24 . The solid dispersion of  claim 18 , wherein said polymer comprises HPMC-AS grade MG or HPMC-AS grade HG. 
     
     
         25 . The solid dispersion of  claim 13 , wherein said non-crystalline fully miscible dispersion further comprises a non-ionic surfactant. 
     
     
         26 . The solid dispersion of  claim 14 , wherein said non-crystalline fully miscible dispersion further comprises a non-ionic surfactant. 
     
     
         27 . The solid dispersion of  claim 15 , wherein said non-crystalline fully miscible dispersion further comprises a non-ionic surfactant. 
     
     
         28 . The solid dispersion of  claim 16 , wherein said non-crystalline fully miscible dispersion further comprises a non-ionic surfactant. 
     
     
         29 . The solid dispersion of  claim 19 , wherein said non-crystalline fully miscible dispersion further comprises a non-ionic surfactant.