US2020399400A1PendingUtilityA1
Antibodies to risperidone haptens and use thereof
Est. expiryAug 21, 2032(~6.1 yrs left)· nominal 20-yr term from priority
Inventors:Eric HryhorenkoBanumathi SankaranThomas R. DecoryTheresa TubbsLinda ColtMaarten VliegenPieter Rik Haspeslagh
G01N 33/94A61P 25/24C07K 16/44A61P 25/18G01N 2800/302
70
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Claims
Abstract
Disclosed is an antibody which binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.
Claims
exact text as granted — not AI-modified1 - 25 . (canceled)
26 . An isolated antibody or a binding fragment thereof, which binds to risperidone and which is generating in response to a conjugate of a compound of Formula I and an immunogenic carrier,
wherein:
R 1 is H, or OH;
R 2 is O(CH 2 ) r NH 2 ,
or O(CH 2 ) r NHC(O)(CH 2 ) m CO 2 H;
wherein:
r is 1, 2, 3, 4, or 5;
m is 1, 2, 3, 4, or 5; and
n is 1, 2, 3, 4, or 5.
27 . The antibody or binding fragment thereof of claim 26 , wherein the antibody binding fragment is selected from the group of fragments consisting of Fv, F(ab′), F(ab′)2, scFv, minibody and diabody fragments.
28 . The antibody or binding fragment thereof of claim 26 , wherein the antibody is a monoclonal antibody.
29 . The antibody or binding fragment thereof of claim 26 , wherein the immunogenic carrier is a protein.
30 . The antibody or binding fragment thereof of claim 29 , wherein the protein is keyhole limpet hemocyanin, bovine thyroglobulin, or ovalbumin.
31 . The antibody or binding fragment thereof of claim 26 , wherein the compound is
r is 1, 2, 3, 4, or 5; and
m is 1, 2, 3, 4, or 5.
32 . The antibody or binding fragment thereof of claim 26 , wherein the compound is
r is 1, 2, 3, 4, or 5; and
m is 1, 2, 3, 4, or 5.
33 . The antibody or binding fragment thereof of claim 26 , wherein the compound is
r is 1, 2, 3, 4, or 5;
m is 1, 2, 3, 4, or 5; and
n is 1, 2, 3, 4, or 5.
34 . The antibody or binding fragment thereof of claim 26 , wherein the compound is
r is 1, 2, 3, 4, or 5;
m is 1, 2, 3, 4, or 5; and
n is 1, 2, 3, 4, or 5.
35 . The antibody or binding fragment thereof of claim 26 , wherein the compound is
r is 1, 2, 3, 4, or 5; and
m is 1, 2, 3, 4, or 5.
36 . The antibody or binding fragment thereof of claim 26 , wherein the compound is
r is 1, 2, 3, 4, or 5; and
m is 1, 2, 3, 4, or 5.
37 . The antibody or binding fragment thereof of claim 26 , wherein the compound is selected from the group consisting of:
38 . The antibody or binding fragment thereof of claim 26 , wherein the compound is
39 . The antibody or binding fragment thereof of claim 26 , wherein the conjugate is
R 1 is H, or OH; and
m is 1, 2, 3, 4, or 5.
40 . The antibody or binding fragment thereof of claim 39 , wherein the protein is keyhole limpet hemocyanin, bovine thyroglobulin, or ovalbumin.
41 . The antibody or binding fragment thereof of claim 39 , wherein the conjugate is
42 . The antibody or binding fragment thereof of claim 41 , wherein the conjugate is
43 . An assay kit comprising the antibody or binding fragment thereof of claim 26 .
44 . An assay device comprising the antibody or binding fragment thereof of claim 26 .
45 . The assay device of claim 44 , wherein the device is a lateral flow assay device.Cited by (0)
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