Cosmetic compositions containing quinones and their topical use on skin and hair

Abstract

Described are compositions containing quinones that show activity in enhance DNA repair and/or prevent damage to DNA. The quinones are thymoquinone, lapachol, myrtucommulone C, or mixtures thereof, and can be formulated into cosmetic compositions for topical administration to a subject in need thereof. The cosmetic compositions can also include sunscreens, surfactants, sunless tanning agents, desquamation agents, antiperspirants, colorants, preservatives and mixtures; and a cosmetically acceptable carrier. The compositions should find use in methods for treating the signs of ageing in mammals via topical application to the skin or hair of the mammals.

1 - 30 . (canceled) 
     
     
         31 . A method for treating sunburn, signs of ageing, or a combination thereof in mammals, comprising topically applying to the skin or hair of the mammals a cosmetic composition comprising a quinone having the structural formula: 
       
         
           
           
               
               
           
         
         in amounts ranging from 0.001% to 10% by weight of the cosmetic composition,
 R5, R6, R7, and R8 are independently hydrogen, unsubstituted C1-C10 alkyl, substituted C1-C10 alkyl, unsubstituted C2-C10 alkenyl, substituted C2-C10 alkenyl, hydroxyl, thiol, halogen, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, substituted alkoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, arylthio, substituted arylthio, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, polyaryl, substituted polyaryl, C 3 -C 20  cyclic, substituted C 3 -C 20  cyclic, heterocyclic, substituted heterocyclic 
 and optionally, a cosmetic functioning component selected from the group consisting of sunscreens, surfactants, sunless tanning agents, desquamation agents, antiperspirants, colorants, preservatives and mixtures thereof in amounts ranging from 0.0001% to 50% by weight of the composition. 
 
       
     
     
         32 . The method according to  claim 31  wherein the signs of ageing are selected from the group consisting of fine lines and wrinkles; lack of skin firmness; reduction of skin luminescence; lack of skin smoothness; lack of skin elasticity; formation of age spots; blotching; sallowness; uneven pigmentation and spider veins. 
     
     
         33 - 42 . (canceled) 
     
     
         43 . The method according to  claim 31  wherein the signs of ageing comprise thinning and loss of hair. 
     
     
         44 . The method according to  claim 31  wherein the signs of ageing comprise lack of hair lustre or shine. 
     
     
         45 . The method according to  claim 31  wherein the signs of ageing comprise hair with split ends. 
     
     
         46 . (canceled) 
     
     
         47 . The method of  claim 31 , wherein R5, R6, R7, and R8 are independently hydrogen, unsubstituted C1-C10 alkyl, substituted C1-C10 alkyl, unsubstituted C2-C10 alkenyl, or substituted C2-C10 alkenyl. 
     
     
         48 . The method of  claim 31 , wherein for Formula II, R5, R6, R7, and R8 are independently hydrogen, C1-C10 alkyl, or substituted C1-C10 alkyl. 
     
     
         49 . The method of  claim 31 , wherein for Formula II, R5, R6, R7, and R8 are hydrogen. 
     
     
         50 . The method of  claim 49 , wherein for Formula II, R1 and R2 are independently unsubstituted C2-C10 alkenyl, substituted C2-C10 alkenyl, C1-C10 alkyl, substituted C1-C10 alkyl, or hydroxyl. 
     
     
         51 . The method of  claim 50 , wherein for Formula II, R1 and R2 are independently unsubstituted C2-C10 alkenyl, substituted C2-C10 alkenyl, or hydroxyl. 
     
     
         52 . The method of  claim 51 , wherein for Formula II, R1 is substituted C2-C10 alkenyl, and R2 is hydroxyl. 
     
     
         53 . The method of  claim 52 , wherein Formula II is 
       
         
           
           
               
               
           
         
       
     
     
         54 . The method of  claim 31 , wherein UV irradiated samples of the quinone or cosmetic composition formulated with the quinone exhibit, in testing against a CUL4A bio target, a reduction in DNA damage relative to a UV irradiated control of at least 10%, as measured by % cyclobutane pyrimidine dimer (CPD) formed in a test cell. 
     
     
         55 . The method of  claim 31 , wherein the composition comprises a sunscreen selected from the group consisting of 2-ethylhexyl p-methoxycinnamate, 4,4′-t-butyl methoxydibenzoylmethane, octylsalicylate, tetraphthalylidene dicarphor sulfonic acid, benzophenone-3, microfine titanium dioxide, microfine zinc oxide and mixtures thereof. 
     
     
         56 . The method of  claim 31 , wherein the composition comprises surfactant selected from the group selected consisting of anionic, nonionic, cationic, and amphoteric type. 
     
     
         57 . The method of  claim 31 , wherein the composition comprises dihydroxy acetone. 
     
     
         59 . The method of  claim 31 , wherein the composition comprises desquamation agents selected from the group consisting of glycolic acid, lactic acid, salicylic acid, retinoic acid, retinol and mixtures thereof, and including salt forms thereof. 
     
     
         60 . The method of  claim 31 , wherein the composition comprises antiperspirants selected from the group consisting of metal salts of aluminum, zinc, zirconium and zirconium aluminum mixtures of sulfates, chlorides, chlorohydroxides, tetrachlorohydrex glycinates, alums, formates, lactates, benzyl sulfonates, succinates, and phenol sulfonates. 
     
     
         61 . The method of  claim 31 , wherein the composition comprises one or more colorants selected from the group consisting of pigments and dyes. 
     
     
         62 . The method of  claim 31 , wherein the compositions comprises one or more preservatives selected from the group consisting of methylchloroisothiazolinone and methylisothiazolinone combinations, phenoxyethanol, methyl paraben, propyl paraben, imidazolidinyl urea, sodium dehydroacetate and benzyl alcohol.