LACTOBACILLUS PLANTARUM STRAIN TCI227 AND USES OF THE LACTOBACILLUS PLANTARUM STRAIN TCI227 FOR REGULATING EXPRESSION OF IL-1BETA GENE, TNF-ALPHA GENE, MMP1a GENE AND TIMP1 GENE, AND TREATING GOUT

Abstract

The present disclosure provides a Lactobacillus plantarum strain and a method for regulating expression of IL-1β gene, TNF-α gene, MMP1α gene and TIMP1 gene, and treating gout using the Lactobacillus plantarum strain.

What is claimed is: 
     
         1 . A method for regulating expression of interleukin-1β (IL-1β) gene, tumor necrosis factor-α (TNF-α) gene, matrix metallopeptidase 1α(MMP1α) gene, and TIMP metallopeptidase inhibitor 1 (TIMP1) gene, comprising administering to a subject in need thereof a composition comprising an effective amount of a  Lactobacillus plantarum  strain. 
     
     
         2 . The method according to  claim 1 , wherein the expression of IL-1β gene, TNF-α gene, and MMP1α gene is down-regulated, and the expression of TIMP1 gene is up-regulated. 
     
     
         3 . The method according to  claim 1 , wherein the effective amount of the  Lactobacillus plantarum  strain is at least 5×10 8  cells/mL. 
     
     
         4 . The method according to  claim 1 , wherein the  Lactobacillus plantarum  strain comprises an inactivated bacterium. 
     
     
         5 . The method according to  claim 1 , wherein the composition is a medicament or a food product. 
     
     
         6 . The method according to  claim 1 , wherein the  Lactobacillus plantarum  strain is deposited in Deutsche Sammlung von Mikroorganismen and Zellkulturen under an accession number DSM 33287. 
     
     
         7 . A method for treating gout, comprising administering to a subject in need thereof a composition comprising an effective amount of a  Lactobacillus plantarum  strain. 
     
     
         8 . The method according to  claim 7 , wherein the effective amount of the  Lactobacillus plantarum  strain is at least 1×10 10  cells/day. 
     
     
         9 . The method according to  claim 7 , wherein the  Lactobacillus plantarum  strain comprises an inactivated bacterium. 
     
     
         10 . The method according to  claim 7 , wherein the composition is a medicament or a food product. 
     
     
         11 . The method according to  claim 7 , wherein the  Lactobacillus plantarum  strain is deposited in Deutsche Sammlung von Mikroorganismen und Zellkulturen under an accession number DSM 33287. 
     
     
         12 . A  Lactobacillus plantarum  strain for relieving gout, which is deposited in Deutsche Sammlung von Mikroorganismen und Zellkulturen under an accession number DSM 33287. 
     
     
         13 . The  Lactobacillus plantarum  strain according to  claim 12 , comprising an inactivated bacterium.