Compositon for preventing or treating osteoporosis

Abstract

The present invention relates to a composition for preventing or treating osteoporosis, comprising a Gentiana scabra extract and a Sambucus williamsii extract, and it is an object of the present invention to provide the composition for preventing or treating osteoporosis, which is capable of increasing bone formation and inhibiting bone resorption. In addition, it is another object of the present invention to provide the composition for preventing or treating osteoporosis, which increases bioaffinity and has no side effects by comprising a Gentiana scabra extract and a Sambucus williamsii extract, which are natural products, thereby stably exhibiting an effect of preventing or treating osteoporosis.

1 . A composition comprising a  Gentiana scabra  extract and a  Sambucus williamsii  extract. 
     
     
         2 . The composition according to  claim 1 , wherein the mixing weight ratio of the  Gentiana scabra  extract and the  Sambucus williamsii  extract is 1:0.1 to 10. 
     
     
         3 . The composition according to  claim 1 , wherein the composition comprises the  Gentiana scabra  extract and the  Sambucus williamsii  extract in an amount of 0.001 to 100% by weight, based on the total weight of the total composition. 
     
     
         4 . The composition according to  claim 1 , wherein the  Gentiana scabra  extract and the  Sambucus williamsii  extract are extracted by hot water extraction. 
     
     
         5 . The composition according to  claim 1 , wherein the composition improves expression of a gene related to bone formation. 
     
     
         6 . The composition according to  claim 5 , wherein the gene related to bone formation is one or more gene selected from the group consisting of ALP, osteocalcin, BMP, TGF-β, and osteoprotegerin. 
     
     
         7 . The composition according to  claim 1 , wherein the composition inhibits expression of a gene related to bone resorption. 
     
     
         8 . The composition according to  claim 7 , wherein the gene related to bone resorption is one or more gene selected from the group consisting of NF-kB, c-FOS, NFATC-1, Cathepsin K, and MMP-9. 
     
     
         9 . A method of preparing the composition according to  claim 1 , comprising the steps:
 1) putting and heating  Gentiana scabra  and  Sambucus williamsii  in a solvent to obtain extracts; and   2) concentrating the extracts obtained from step 1) under reduced pressure.   
     
     
         10 . The method of preparing the composition according to  claim 9 , wherein the heating temperature in step 1) is 80 to 100° C. 
     
     
         11 . The method of preparing the composition according to  claim 9 , wherein step 2) is carried out at 30 to 70° C. 
     
     
         12 . A method for preventing and/or treating a subject with osteroporosis comprising administering a composition comprising a  Gentiana scabra  extract and a  Sambucus williamsii  extract to the subject. 
     
     
         13 . The method according to  claim 12 , wherein a weight ratio of the  Gentiana scabra  extract and the  Sambucus williamsii  extract in the composition is 1:0.1 to 10. 
     
     
         14 . The method according to  claim 12 , wherein the composition comprises the  Gentiana scabra  extract and the  Sambucus williamsii  extract in an amount of 0.001 to 100% by weight, based on the total weight of the total composition. 
     
     
         15 . The method according to  claim 12 , wherein the  Gentiana scabra  extract and the  Sambucus williamsii  extract are obtained by hot water extraction. 
     
     
         16 . The method according to  claim 12 , wherein the administering the composition to the subject improves expression of a gene related to bone formation in the subject. 
     
     
         17 . The method according to  claim 16 , wherein the gene related to bone formation is one or more gene selected from the group consisting of ALP, osteocalcin, BMP, TGF-β, and osteoprotegerin. 
     
     
         18 . The method according to  claim 12 , wherein the administration of the composition to the subject inhibits expression of a gene related to bone resorption in the subject. 
     
     
         19 . The method according to  claim 18 , wherein the gene related to bone resorption is one or more gene selected from the group consisting of NF-kB, c-FOS, NFATC-1, Cathepsin K, and MMP-9.