Curable calcium phosphate compositions for use with porous structures and methods of using the same

Abstract

Various embodiments disclosed relate to curable calcium phosphate compositions for use with porous structures and methods of using the same. In various embodiments, the present invention provides a curable calcium phosphate composition or a cured product thereof, with the curable calcium phosphate composition including calcium phosphate and a perfusion modifier. In various embodiments, the present invention provides an apparatus comprising a porous structure at least partially in contact with the curable calcium phosphate composition or a cured product thereof. The porous structure can include a porous substrate including a plurality of ligaments that define pores of the porous substrate, and a biocompatible metal coating on the plurality of ligaments of the porous substrate.

What is claimed is: 
     
         1 . A curable calcium phosphate composition or a cured product thereof, the curable calcium phosphate composition comprising:
 calcium phosphate;   a perfusion modifier, wherein the perfusion modifier is 0.5 wt % to 5 wt % of the curable calcium phosphate composition, wherein the perfusion modifier is methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, a salt thereof, or a combination thereof; and   a physiologically acceptable fluid.   
     
     
         2 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the physiologically acceptable fluid comprises water, saline, phosphate buffer, biological fluid, or a combination thereof, and the biological fluid comprises blood, a blood component, a blood product, milk, urine, saliva, seminal fluid, vaginal fluid, synovial fluid, lymph fluid, amniotic fluid, the fluid within a yolk sac of an egg, chorion of an egg, allantois of an egg, sweat, tears, or a combination thereof. 
     
     
         3 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the calcium phosphate is about 40 wt % to about 70 wt % of the curable calcium phosphate composition. 
     
     
         4 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the calcium phosphate comprises amorphous calcium phosphate, poorly crystalline calcium phosphate, hydroxyapatite, carbonated apatite, monocalcium phosphate, calcium metaphosphate, heptacalcium phosphate, dicalcium phosphate dihydrate, tetracalcium phosphate, octacalcium phosphate, calcium pyrophosphate, tricalcium phosphate, or a combination thereof. 
     
     
         5 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the calcium phosphate comprises amorphous calcium phosphate and dicalcium phosphate dihydrate. 
     
     
         6 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the curable calcium phosphate composition further comprises a polymer. 
     
     
         7 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the curable calcium phosphate composition further comprises a polysaccharide, a nucleic acid, a carbohydrate, a protein, a polypeptide, a poly(α-hydroxy acid), a poly(lactone), a poly(amino acid), a poly(anhydride), a poly(orthoester), a poly(anhydride-co-imide), a poly(orthocarbonate), a poly(α-hydroxy alkanoate), a poly(dioxanone), a poly(phosphoester), sodium alginate, alginic acid, arabic gum, guar gum, xantham gum, gelatin, chitin, chitosan, chitosan acetate, chitosan lactate, chondroitin sulfate, N,O-carboxymethyl chitosan, a dextran, fibrin glue, glycerol, hyaluronic acid, sodium hyaluronate, a cellulose, a glucosamine, a proteoglycan, a starch, lactic acid, a poly(ethylene oxide-co-propylene oxide), sodium glycerophosphate, collagen, glycogen, a keratin, silk, poly(L-lactide) (PLLA), poly(D,L-lactide) (PDLLA), polyglycolide (PGA), poly(lactide-co-glycolide) (PLGA), poly(L-lactide-co-D, L-lactide), poly(D,L-lactide-co-trimethylene carbonate), polyhydroxybutyrate (PHB), poly(ϵ-caprolactone), poly(δ-valerolactone), poly(δ-butyrolactone), poly(caprolactone), polyacrylic acid, polycarboxylic acid, poly(allylamine hydrochloride), poly(diallyldimethylammonium chloride), poly(ethyleneimine), polypropylene fumarate, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene, polymethylmethacrylate, carbon fibers, poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), poly(vinylpyrrolidone), poly(ethyloxazoline), poly(ethylene oxide)-co-poly(propylene oxide) block copolymers, poly(ethylene terephthalate)polyamide, copolymers thereof, or a combination thereof. 
     
     
         8 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the perfusion modifier is carboxymethylcellulose, a salt thereof, or a combination thereof. 
     
     
         9 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the perfusion modifier is a lyophilized perfusion modifier. 
     
     
         10 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the curable calcium phosphate composition further comprises a biologically active modifier that is at least one of an antibody, an antibiotic, a polynucleotide, a polypeptide, a protein, an anti-cancer modifier, a growth factor, a vaccine, or a combination thereof, wherein the biologically active modifier is about 0.001 wt % to about 40 wt % of the curable calcium phosphate composition. 
     
     
         11 . The curable calcium phosphate composition or cured product thereof of  claim 10 , wherein the biologically active modifier is about 0.001 wt % to about 10 wt % of the curable calcium phosphate composition. 
     
     
         12 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the curable calcium phosphate composition further comprises a binder that is about 0.001 wt % to about 20 wt % of the curable calcium phosphate composition. 
     
     
         13 . The curable calcium phosphate composition or cured product thereof of  claim 12 , wherein the binder is about 0.001 wt % to about 5 wt % of the curable calcium phosphate composition. 
     
     
         14 . The curable calcium phosphate composition or cured product thereof of  claim 12 , wherein the binder is at least one of a) a polysaccharide, a nucleic acid, a carbohydrate, a protein, a polypeptide, a poly(α-hydroxy acids), a poly(lactone), a poly(amino acid), a poly(anhydride), a poly(orthoester), a poly(anhydride-co-imide), a poly(orthocarbonate), a poly(α-hydroxy alkanoate), a poly(dioxanone), a poly(phosphoester), poly(L-lactide) (PLEA), poly(D,L-lactide) (PDLEA), polyglycolide (PGA), poly(lactide-co-glycolide (PLEA), poly(L-lactide-co-D, L-lactide), poly(D,L-lactide-co-trimethylene carbonate), polyhydroxybutyrate (PHB), poly(ϵ-caprolactone), poly(δ-valerolactone), poly(γ-butyrolactone), poly(caprolactone), polyacrylic acid, polycarboxylic acid, poly(allylamine hydrochloride), poly(diallyldimethylammonium chloride), poly(ethyleneimine), polypropylene fumarate, polyvinyl alcohol, polyvinylpyrrolidone, a polyethylene, polymethylmethacrylate, a carbon fiber, poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), poly(vinylpyrrolidone), poly(ethyloxazoline), a poly(ethylene oxide)-co-poly(propylene oxide) block copolymer, poly(ethylene terephthalate)polyamide, and copolymers thereof; b) a homo- or co-polymer having one or more monomers selected from the group consisting of acrolein potassium, (meth)acrylamides, (meth)acrylic acid and salts thereof, (meth)acrylates, acrylonitrile, ethylene, ethylene glycol, ethyleneimine, ethyleneoxide, styrene sulfonate, vinyl acetate, vinyl alcohol, vinyl chloride, and vinylpyrrolidone); c) a polyphenol complexing agent selected from a gallotannin, a ellagitannin, a taragallotannin, a caffetannin, a proanthocyanidin, catechin, epi catechin, chlorogenic acid, and arbutin; and d) an agent selected from alginic acid, arabic gum, guar gum, xanthan gum, gelatin, chitin, chitosan, chitosan acetate, chitosan lactate, chondroitin sulfate, N,O-carboxymethyl chitosan, a dextran, fibrin glue, glycerol, hyaluronic acid, sodium hyaluronate, a cellulose, a glucosamine, a proteoglycan, a starch, lactic acid, a poly(ethylene oxide-co-propylene oxide), sodium glycerophosphate, collagen, glycogen, a keratin, and silk. 
     
     
         15 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the curable calcium phosphate composition further comprises an effervescent agent that is about 0.001 wt % to about 40 wt % of the curable calcium phosphate composition. 
     
     
         16 . The curable calcium phosphate composition or cured product thereof of  claim 15 , wherein the effervescent agent is 1 wt % to 10 wt % of the curable calcium phosphate composition. 
     
     
         17 . The curable calcium phosphate composition or cured product thereof of  claim 15 , wherein the effervescent agent comprises a carbonate compound and a bicarbonate compound which react upon hydration of said composition to produce carbon dioxide. 
     
     
         18 . The curable calcium phosphate composition or cured product thereof of  claim 1 , wherein the curable calcium phosphate composition further comprises demineralized bone that is about 0.001 wt % to about 40 wt % of the curable calcium phosphate composition. 
     
     
         19 . The curable calcium phosphate composition or cured product thereof of  claim 1 , comprising the cured product of the calcium phosphate composition. 
     
     
         20 . A method comprising treating a joint disorder or condition with the curable calcium phosphate composition of cured product thereof of  claim 1 .