Use of pasteurized akkermansia for treating metabolic disorders

Abstract

The present invention relates to pasteurized Akkermansia muciniphila or fragments thereof for treating a metabolic disorder in a subject in need thereof. The present invention also relates to a composition, a pharmaceutical composition and a medicament comprising pasteurized Akkermansia muciniphila or fragments thereof for treating a metabolic disorder. The present invention also relates to the use of pasteurized Akkermansia muciniphila or fragments thereof for promoting weight loss in a subject in need thereof.

1 . A method for treating a metabolic disorder in a subject in need thereof, comprising administering to the subject  Akkermansia muciniphila  or fragments thereof, wherein the  Akkermansia muciniphila  is pasteurized. 
     
     
         2 . The method of  claim 1 , wherein said metabolic disorder is obesity. 
     
     
         3 . The method of  claim 1 , wherein said metabolic disorder is selected from the group consisting of: metabolic syndrome; insulin-deficiency or insulin-resistance related disorders; diabetes mellitus including type 2 diabetes; glucose intolerance; abnormal lipid metabolism; atherosclerosis; hypertension; pre-eclampsia; cardiac pathology; stroke; non-alcoholic fatty liver disease; hyperglycemia; hepatic steatosis; liver diseases including fibrosis associated with obesity and abnormal liver functions, more particularly changes in bile production and immunity; dyslipidemia; dysfunction of the immune system associated with overweight and obesity; inflammatory, immune and barrier function diseases including inflammatory bowel disease, more particularly Crohn's disease and ulcerative colitis, and irritable bowel syndrome; cardiovascular diseases; high cholesterol; elevated triglycerides; asthma; sleep apnea; osteoarthritis; neuro-degeneration; gallbladder disease; syndrome X; atherogenic dyslipidemia; and cancer. 
     
     
         4 . A method for
 a) increasing energy expenditure of a subject, optionally without impacting the food intake of said subject; or   b) increasing satiety in a subject,   comprising administering  Akkermansia muciniphila  or fragments thereof to the subject, wherein the  Akkermansia muciniphila  is pasteurized.   
     
     
         5 . (canceled) 
     
     
         6 . The method of  claim 1 , wherein the  Akkermansia muciniphila  is orally administered. 
     
     
         7 . The method of  claim 1 , wherein the  Akkermansia muciniphila  is administered to the subject in an amount from about 1.10 4  to about 1.10 12  cells, about 1.10 5  to about 1.10 11  cells, or from about 1.10 6  to about 1.10 10  cells. 
     
     
         8 . The method of  claim 1 , wherein the  Akkermansia muciniphila  is administered at least three times a week. 
     
     
         9 . The method of  claim 1 , wherein the  Akkermansia muciniphila  is co-administered with another probiotic strain and/or another bacteria and/or microorganisms with beneficial effects and/or with one or more prebiotics. 
     
     
         10 . The method of  claim 1 , wherein the  Akkermansia muciniphila  or fragments thereof is administered as a composition according to any one of  claims 1  to  9  in association with an excipient. 
     
     
         11 . The method of  claim 10 , wherein said composition is a nutritional composition. 
     
     
         12 . The method of  claim 10 , wherein said composition is orally administered. 
     
     
         13 . The method of  claim 1 , wherein the  Akkermansia muciniphila  is administered as a pharmaceutical composition in association with a pharmaceutically acceptable vehicle. 
     
     
         14 . (canceled) 
     
     
         15 . A method for weight loss in a subject in need thereof, comprising administering  Akkermansia muciniphila  or fragments thereof to the subject, wherein the  Akkermansia muciniphila  is pasteurized. 
     
     
         16 . The method of  claim 15 , wherein the  Akkermansia muciniphila  is administered as a cosmetic composition, and wherein the  Akkermansia muciniphila  is pasteurized.