Methods of treating stroke

Abstract

Methods and compositions for treating stroke are disclosed.

What is claimed is: 
     
         1 . A method of treating ischemia-reperfusion injury manifested by gastrointestinal dysfunction in a subject, the method comprising administering to the subject a humanized AQC2 blocking anti-Very Late Activation Antigen-1 (VLA-1) antibody, or an antigen-binding fragment thereof, in an amount effective to treat the injury. 
     
     
         2 . The method of  claim 1 , wherein the humanized AQC2 blocking VLA-1 antibody, or the antigen-binding fragment thereof, is produced by a hybridoma having ATCC Deposit No. PTA-3274. 
     
     
         3 . The method of  claim 1 , wherein the humanized AQC2 blocking VLA-1 antibody, or the antigen binding fragment thereof, is administered intravenously or parenterally to the subject. 
     
     
         4 . The method of  claim 1 , wherein the gastrointestinal dysfunction comprises hemorrhage, infarction, multisystem organ dysfunction (MSOD), or acute systemic inflammatory distress syndrome (SIRS). 
     
     
         5 . The method of  claim 1 , wherein the subject is a mammal. 
     
     
         6 . The method of  claim 1 , wherein the subject is a human. 
     
     
         7 . The method of  claim 1 , wherein the humanized AQC2 blocking VLA-1 antibody, or the antigen-binding fragment thereof, is administered in combination with another therapeutic agent.