Composition and dressing with nitric oxide

Abstract

A dressing composition for use as a skin dressing comprises an elastomeric-adhesive composition, and a zeolite comprising releasably adsorbed nitric oxide. The zeolite may comprise a transition metal cation such as Co, Fe, Mn, Ni, Cu, Zn, Ag or a mixture thereof as an extra-framework metal cation, preferably Zn. The elastomeric adhesive composition may be a hydrocolloid-adhesive composition comprising, hydrocolloid and elastomer. The dressing composition releases nitric oxide, which may have beneficial effects, when used on wounds or moist skin, with a substantially constant release rate over a long period of time. A dressing including a layer of the dressing composition has a backing layer and may have a release liner removably attached to the skin-contacting surface of the dressing layer.

1 - 17 . (canceled) 
     
     
         18 . A nitric oxide-releasing dressing composition for use as a skin dressing comprising:
 i) between 30% and 96% by weight of an elastomeric-adhesive composition, and   ii) between 4% and 70% by weight of a zeolite dispersed within the elastomeric-adhesive composition, said zeolite comprising releasably adsorbed nitric oxide and a zinc metal cation as an extra-framework metal cation providing positive charge,   wherein the dressing composition releases nitric oxide at a generally uniform rate over an extended time period.   
     
     
         19 . The composition of  claim 18 , comprising between 30% and 90% by weight of an elastotneric-adhesive composition, and from 10% to 70% by weight of zeolite. 
     
     
         20 . The composition of  claim 18 , wherein the zeolite is selected from the group consisting of zeolite P, zeolite A, zeolite X, zeolite Y and mixtures thereof. 
     
     
         21 . The composition of  claim 18 , wherein 20 molar % or more of the extra framework cation of the zeolite is a zinc metal cation. 
     
     
         22 . The composition of  claim 18 , wherein 50 molar % or more of the extra framework cation of the zeolite is a zinc metal cation. 
     
     
         23 . The composition of  claim 18 , wherein the zeolite comprises at least 0.5 mmol/g of releasably adsorbed nitric oxide. 
     
     
         24 . The composition of  claim 18 , wherein the elastotneric adhesive composition is a hydrocolloid-adhesive composition comprising, by weight of the hydrocolloid-adhesive composition, from 15 to 70% by weight of a hydrocolloid and from 30 to 85% by weight of an elastomer. 
     
     
         25 . A dressing for application to skin comprising a backing layer holding a dressing layer comprising a skin contacting surface and the dressing composition of  claim 18 . 
     
     
         26 . A method for the treatment of a human or animal body comprising applying to the human or animal body the composition according to  claim 18 . 
     
     
         27 . A method for the treatment of a human or animal body comprising applying to the human or animal body the composition according to  claim 25 . 
     
     
         28 . A nitric oxide-releasing dressing composition for use as a skin dressing comprising:
 i) between 30% and 96% by weight of an elastomeric-adhesive composition comprising an elastomeric polymer in combination with one or more water-soluble or water-swellable hydrocolloids;   
       wherein the elastomeric polymer is selected from the group consisting of:
 natural or synthetic rubber or mixtures thereof, block copolymers of styrene/butadiene, polybutenes and polyacrylates; and 
 the one or more water-soluble or water-swellable hydrocolloids are selected from the group consisting of: 
 polyhydroxyalkyl acrylates and methacrylates, polyvinyl lactams, polyvinyl alcohols, polyoxyalkylenes, polyacrylamides, polyacrylic acid, polystyrene sulfonates, natural or synthetically modified polysaccharides, alginates, gelatine, xanthan gums, guar gums, and cellulosic polymers; and 
 ii) between 4% and 70% by weight of a zeolite dispersed within the elastomeric-adhesive composition, said zeolite comprising releasably adsorbed nitric oxide. 
 
     
     
         29 . The dressing composition as claimed in  claim 28 , having between 30% and 90% by weight of the elastomeric-adhesive composition and between 10% and 70% by weight of the zeolite. 
     
     
         30 . The dressing composition according to  claim 28 , wherein the elastomeric-adhesive composition comprises, based on the weight of the elastomeric-adhesive composition, from 15 to 70% by weight of the hydrocolloid and from 30 to 85% by weight of the elastomeric polymer. 
     
     
         31 . The dressing composition as claimed in  claim 28 , wherein the water-soluble or water-swellable hydrocolloids are selected from the group consisting of: polyvinyl alcohols, powdered pectin, gelatine, methyl cellulose, hydroxypropyl methyl cellulose, carboxymethylcellulose (CMC), hydroxypropyl cellulose and mixtures thereof. 
     
     
         32 . The dressing composition according to  claim 28 , wherein the zeolite is selected from the group consisting of, zeolite P, zeolite A, zeolite X, zeolite Y and mixtures thereof. 
     
     
         33 . The dressing composition according to  claim 28 , wherein the zeolite comprises a transition metal cation as an extra-framework metal cation, the metal selected from the group consisting of Co, Fe, Mn, Ni, Cu, Zn, Ag and a mixture thereof. 
     
     
         34 . The dressing composition according to  claim 28 , wherein the extra-framework metal cation is Zn. 
     
     
         35 . The dressing composition according to  claim 28 , wherein the dressing composition releases nitric oxide at a generally uniform rate over an extended time period. 
     
     
         36 . A dressing for application to skin comprising a backing layer holding a dressing layer comprising a skin contacting surface and a dressing composition according to  claim 28 . 
     
     
         37 . A method for the treatment of a human or animal body comprising applying to the human or animal body the dressing composition according to  claim 28 .