Composition and method for vancomycin oral liquid

Abstract

The invention relates to stable vancomycin hydrochloride powder for oral liquid formulations. Also provided herein are methods of using vancomycin oral liquid formulations for the treatment of certain diseases such as Clostridium difficile pseudomembranous colitis and Staphylococcal enterocolitis as well as kits and related products thereof.

What is claimed is: 
     
         1 - 17 . (canceled) 
     
     
         18 . A non-sterile stable liquid formulation formulated for oral administration, comprising:
 (a) citric acid,   (b) water,   (c) a sweetener,   (d) a preservative, wherein the preservative is selected from the group consisting of benzyl alcohol, sodium benzoate, parabens, benzoic acid, and potassium sorbate, and   (e) vancomycin hydrochloride, and   wherein the non-sterile stable liquid formulation is homogenous and stable for at least 1 week at refrigerated temperature and has a pH of 2.5-4.5.   
     
     
         19 . The liquid formulation of  claim 18 , wherein the liquid formulation has 0.1-0.4% w/v citric acid. 
     
     
         20 . The liquid formulation of  claim 18 , wherein the liquid formulation has 0.2% w/v sucralose. 
     
     
         21 . The liquid formulation of  claim 18 , wherein the liquid formulation has a flavoring agent. 
     
     
         22 . The liquid formulation of  claim 21 , wherein the flavoring agent is 0.05% w/v artificial grape flavor. 
     
     
         23 . The liquid formulation of  claim 18 , wherein the preservative is sodium benzoate.