Multiparticulate formulations of cannabinoids

Abstract

Compositions for the immediate release, extended release, or sustained release of two or more active agents, in which the two or more active agents comprises at least one cannabinoid and at least one non-cannabinoid therapeutic agent. The compositions comprise a population of particles, in which each particles comprises the at least one cannabinoid, the at least one non-cannabinoid therapeutic agent, or a combination thereof.

What is claimed is: 
     
         1 . A composition for extended release of two or more active agents, wherein the two or more active agents comprise at least one cannabinoid and at least one non-cannabinoid therapeutic agent,
 the composition comprising a population of particles, wherein each particle comprises:
 (a) the at least one cannabinoid, the at least one non-cannabinoid therapeutic agent, or a combination thereof; 
 (b) one or more drug releasing agents; 
 (c) a core; and 
 (d) one or more surfactants; 
   wherein the composition releases the two or more actives over a period of at least 6 hours.   
     
     
         2 . The composition of  claim 1 , wherein the one or more drug releasing agents comprises one or more gel-forming agents. 
     
     
         3 . The composition of  claim 2 , wherein the one or more gel-forming agents is selected from glyceryl monooleate, glycerol monostearate, soybean oil, propylene glycol monopalmitostearate, carboxypolymethylene, hydroxypropyl cellulose, hydroxypropyl methycellulose, carboxymethyl cellulose, chitosan, acacia, alginates, carrageen, and guar gum. 
     
     
         4 . The composition of  claim 1 , wherein the core comprises a silica bead or porous biodegradable glass bead. 
     
     
         5 . The composition of  claim 1 , wherein the core comprises one or more pores that extend from the surface of the core. 
     
     
         6 . A composition for extended release of two or more active agents, wherein the two or more active agents comprise at least one cannabinoid and at least one non-cannabinoid therapeutic agent,
 the composition comprising a population of particles, wherein each particle comprises:
 (a) the at least one cannabinoid, the at least one non-cannabinoid therapeutic agent, or a combination thereof; 
 (b) one or more drug releasing agents; and 
 (c) a core, 
   wherein the composition releases the two or more active agents over a period of at least 6 hours.   
     
     
         7 . The composition of  claim 6 , wherein the core comprises a coating that comprises the two or more active agents and the one or more drug releasing agents. 
     
     
         8 . The composition of  claim 6 , wherein the one or more drug releasing agents comprise one or more release-controlling polymers, one or more release-accelerating polymers, or a combination thereof. 
     
     
         9 . The composition of  claim 8 , wherein the one or more release-controlling polymers are selected from the group consisting of ethyl cellulose, polyvinyl acetate-based polymers, polyvinyl acetate-based co-polymers, polyacrylic acid-based polymers, polyacrylic acid-based co-polymers, methacrylic acid polymers, methacrylic acid polymers copolymers, polyvinyl alcohol, and a combination thereof.