Adipose tissue products and methods of production

Abstract

Compositions and methods for treating tissue are provided. The compositions may include tissue matrix derived from adipose tissue suitable for injection, small-volume implantation, or use as a soft-tissue regenerative material. Also provided are methods for producing such compositions.

What is claimed is: 
     
         1 . A tissue product, comprising:
 a particulate tissue matrix composition comprising adipose acellular tissue matrix particles having a longest dimension between about 0.05 mm and 3 mm, the particles comprising a micro-porous structure derived from a porous sponge from which the particles are produced, wherein the sponge is formed from a stabilized suspension of mechanically processed adipose acellular tissue.   
     
     
         2 . The tissue product of  claim 1 , wherein the stabilized suspension comprises between about 2% to about 10% solid adipose acellular tissue matrix by weight. 
     
     
         3 . The tissue product of  claim 2 , wherein the stabilized suspension comprises between about 2% to about 5% solid adipose acellular tissue matrix by weight. 
     
     
         4 . The tissue product of  claim 1 , wherein the particles are dry. 
     
     
         5 . The tissue product of  claim 1 , further comprising a flowable carrier. 
     
     
         6 . The tissue product of  claim 5 , wherein the flowable carrier comprises an aqueous fluid. 
     
     
         7 . The tissue product of  claim 6 , wherein the flowable carrier comprises saline. 
     
     
         8 . The tissue product of  claim 6 , wherein the tissue product comprises between 80-95% by weight water. 
     
     
         9 . The tissue product of  claim 6 , wherein the tissue product comprises between 90-98% by weight water. 
     
     
         10 . The tissue product of  claim 6 , wherein the tissue product comprises between 95-98% by weight water. 
     
     
         11 . The tissue product of  claim 6 , wherein the tissue product comprises between 5% and 15% by weight adipose tissue matrix protein. 
     
     
         12 . The tissue product of  claim 6 , wherein the tissue product comprises between 5% and 12% by weight adipose tissue matrix protein. 
     
     
         13 . The tissue product of  claim 5 , wherein the flowable carrier is a flowable hyaluronic acid carrier. 
     
     
         14 . The tissue product of  claim 13 , wherein the hyaluronic acid is non-cross-linked. 
     
     
         15 . The tissue product of  claim 13 , wherein the hyaluronic acid is cross-linked. 
     
     
         16 . The tissue product of  claim 13 , wherein the tissue product comprises particulate tissue matrix and hyaluronic acid at a ratio of between 9:1 and 4:1 by volume. 
     
     
         17 . The tissue product of  claim 1 , wherein the particles comprise a longest dimension between 50 microns to 4 mm. 
     
     
         18 . The tissue product of  claim 1 , wherein the particles comprise a longest dimension between 1.5 mm to 4 mm. 
     
     
         19 . The tissue product of  claim 1 , wherein the particles comprise a longest dimension between 2 mm to 3.5 mm. 
     
     
         20 . The tissue product of  claim 1 , wherein the particles comprise a longest dimension between 2 mm to 3 mm.