Composition containing monoacetyldiglyceride compound as active ingredient for preventing or treating chronic obstructive pulmonary disease

Abstract

The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.

1 - 13 . (canceled) 
     
     
         14 . A method of treating a chronic obstructive pulmonary disease in a patient, comprising administering to a patient in need of such treatment an effective amount of a monoacetyldiacylglycerol compound of [Formula 1] 
       
         
           
           
               
               
           
         
       
       wherein R1 and R2 are independently a fatty acid group of 14 to 20 carbon atoms. 
     
     
         15 . The method according to  claim 14 , wherein R1 and R2 are independently selected from the group consisting of palmitoyl, oleoyl, linoleoyl, linolenoyl, stearoyl, myristoyl, and arachidonoyl. 
     
     
         16 . The method according to  claim 14 , wherein R1 and R2 (R1/R2) is selected from the group consisting of oleoyl/palmitoyl, palmitoyl/oleoyl, palmitoyl/linoleoyl, palmitoyl/linolenoyl, palmitoyl/arachidonoyl, palmitoyl/stearoyl, palmitoyl/palmitoyl, oleoyl/stearoyl, linoleoyl/palmitoyl, linoleoyl/stearoyl, stearoyl/linoleoyl, stearoyl/oleoyl, myristoyl/linoleoyl, myristoyl/oleoyl. 
     
     
         17 . The method according to  claim 14 , wherein the monoacetyldiacylglycerol compound is a compound of Formula 2: 
       
         
           
           
               
               
           
         
       
     
     
         18 . The method according to  claim 14 , wherein the chronic obstructive pulmonary disease is chronic bronchitis. 
     
     
         19 . The method according to  claim 14 , wherein the chronic obstructive pulmonary disease is emphysema. 
     
     
         20 . The method according to  claim 14 , wherein the patient is identified as suffering from chronic obstructive pulmonary disease and the compound of Formula is administered to the identified patient. 
     
     
         21 . The method according to  claim 17 , wherein the chronic obstructive pulmonary disease is chronic bronchitis. 
     
     
         22 . The method according to  claim 17 , wherein the chronic obstructive pulmonary disease is emphysema. 
     
     
         23 . The method according to  claim 17 , wherein the patient is identified as suffering from chronic obstructive pulmonary disease and the compound of Formula is administered to the identified patient.