Polymers for reversing heparin-based anticoagulation

Abstract

Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.

1 . A method of counteracting heparin in a subject, the method comprising:
 administering a heparin binding polymer to the subject, wherein the heparin binding polymer comprises:
 a core unit, wherein the core unit comprises a C 1-18  alkyl substituted with three or more of —OR 1 ,
 wherein each R 1  is independently selected from a polymer segment having monomer units of Formula (III): 
 
   
       
         
           
           
               
               
           
         
         
           
             
               wherein n is an integer from 1 to 10,000, 
               wherein each R 2  is independently selected from a hydrogen, carbon, a cationic moiety, R 1 , and a polymer segment of Formula (IV): 
             
           
         
       
       
         
           
           
               
               
           
         
         
           
             
               wherein each R 3  is independently selected from an oxygen cationic moiety, a hydroxyl, and a polymer segment of Formula (IV), 
               wherein m is an integer from 1 to 10,000, 
               wherein each R 4  is independently selected from a C 1-6  alkoxy, and 
             
           
         
         wherein the heparin binding polymer comprises 1 to 300 cationic moieties.