Nutritional supplement for improving sexual health in men and women

Abstract

The invention provides compositions and methods that are effective to improve NO production in vivo and/or to increase NO levels in blood. Such compositions and methods are useful to improve sexual function in males and females.

What is claimed is: 
     
         1 . A unit dosage form suitable for oral administration to a human comprising:
 L-citrulline 500 mg±20 mg;   L-arginine 250 mg±20 mg; and   at least about 5 mg piperine.   
     
     
         2 . The unit dosage form of  claim 1  that comprises at least about 5.0 mg piperine. 
     
     
         3 . The unit dosage form of  claim 1  that comprises at least about 5.3 mg piperine. 
     
     
         4 . The unit dosage form of  claim 1  that comprises at least about 5.5 mg piperine. 
     
     
         5 . The unit dosage form of  claim 1  that further comprises microcrystalline cellulose, silicon dioxide, and magnesium stearate. 
     
     
         6 . The unit dosage form of  claim 1  that comprises at least about 480 mg of L-citrulline. 
     
     
         7 . The unit dosage form of  claim 1  that comprises at least about 490 mg of L-citrulline. 
     
     
         8 . The unit dosage form of  claim 1  that comprises at least about 500 mg of L-citrulline. 
     
     
         9 . The unit dosage form of  claim 1  that comprises at least about 230 mg of L-arginine. 
     
     
         10 . The unit dosage form of  claim 1  that comprises at least about 240 mg of L-arginine. 
     
     
         11 . The unit dosage form of  claim 1  that comprises at least about 250 mg of L-arginine. 
     
     
         12 . The unit dosage form of  claim 1  that comprises:
 about 500 mg of L-citrulline; 
 about 250 mg of L-arginine; and 
 about 1.75 mg of bioperine. 
 
     
     
         13 . The unit dosage form of  claim 1  wherein the piperine is synthetically produced piperine. 
     
     
         14 . The unit dosage form of  claim 1  the piperine is an extract from the fruit of Piper. 
     
     
         15 . The unit dosage form of  claim 12  that further comprises microcrystalline cellulose, silicon dioxide, and magnesium stearate. 
     
     
         16 . The unit dosage form of  claim 1  that is formulated as a capsule, powder or liquid. 
     
     
         17 . A method to increase NO levels in the blood of a mammal comprising administering a unit dosage form of  claim 1  to the mammal. 
     
     
         18 . A method to treat erectile dysfunction in a mammal comprising administering a unit dosage form of  claim 1  to the mammal. 
     
     
         19 . A method to improve sexual function in a mammal comprising administering a unit dosage form of  claim 1  to the mammal. 
     
     
         20 . A method to improve erection hardness, erection maintenance, frequency of intercourse, partner satisfaction, or overall satisfaction with sexual health in a male human comprising administering a unit dosage form of  claim 1  to the male human. 
     
     
         21 . A method to improve lubrication, sexual desire, ability to be aroused or frequency of intercourse, in a female human comprising administering a unit dosage form of  claim 1  to the female human.