Compositions comprising 15-hepe and methods of treating or preventing cancer and neurologic disease

Abstract

The present disclosure provides compositions comprising 15-HEPE and methods of using same for treating and/or preventing cancer and neurological diseases in a subject in need thereof.

1 - 9 . (canceled) 
     
     
         10 . A method of treating and/or preventing a central nervous system (CNS) disease in a subject in need thereof, the method comprising administering to the subject 15-HEPE or a composition comprising 15-HEPE. 
     
     
         11 . The method of  claim 10 , wherein the 15-HEPE is in free acid form. 
     
     
         12 . The method of  claim 10 , wherein the 15-HEPE is in esterified form. 
     
     
         13 . The method of  claim 12 , wherein the esterified form is an alkyl ester form. 
     
     
         14 . The method of  claim 13 , wherein the esterified form is ethyl ester. 
     
     
         15 . The method of  claim 12 , wherein the esterified form is a triglyceride form. 
     
     
         16 . The method of  claim 10 , wherein the CNS disease is selected from catalepsy, epilepsy, encephalitis, meningitis, migraine, Huntington's, Alzheimer's, Parkinson's, and multiple sclerosis. 
     
     
         17 . The method of  claim 10 , wherein the 15-HEPE comprises, consists essentially of, or consists of 15(S)-HEPE or a derivative thereof. 
     
     
         18 . The method of  claim 10 , wherein the 15-HEPE comprises, consists essentially of, or consists of 15(R)-HEPE or a derivative thereof. 
     
     
         19 . (canceled)