Methods for treating alopecia and achromotrichia

Abstract

or a pharmaceutically acceptable salt or ester thereof, minoxidil and cyclosporine A.

What is claimed is: 
     
         1 . A method of simultaneously treating alopecia and achromotrichia comprising topically administering to a human in need thereof an effective amount of a composition comprising a compound of formula (II) 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or ester thereof, minoxidil and cyclosporine A. 
     
     
         2 . The method of  claim 1 , wherein the achromotrichia is due to aging. 
     
     
         3 . The method of  claim 1 , wherein the composition further comprises one or more excipients selected from the group consisting of urea, polyoxyl 40 stearate, a carbomer, cetyl alcohol, glyceryl monostearate, mineral oil, ethanol, propylene glycol, polyglycol 300, citric acid, sodium phosphate dibasic, stearyl alcohol, isopropyl myristate, sodium hydroxide, petroleum jelly, xanthan gum, white petrolatum, sorbitol solution, cetearyl alcohol, ceteareth-20, simethicone, sodium benzoate, glyceryl monostearate, polyethylene glycol monostearate, sorbic acid, butylated hydroxytoluene and water. 
     
     
         4 . The method of  claim 1 , wherein minoxidil is at a concentration from about 1% to about 10% w/v, cyclosporine A is at a concentration from about 0.01% to about 1% w/v and the compound of formula (II) or a pharmaceutically acceptable salt or ester thereof is at a concentration from about 0.000001% to about 0.0001% w/v, wherein w/v denotes weight by volume. 
     
     
         5 . The method of  claim 1 , wherein the composition further comprises ethanol at a concentration from about 10% to about 50% w/v, propylene glycol at a concentration from about 10% to about 70% w/v and water at a concentration from about 10% to about 50% w/v. 
     
     
         6 . The method of  claim 1 , wherein the composition further comprises 40% w/v urea. 
     
     
         7 . The method of  claim 1 , wherein the composition further comprises polyoxyl 40 stearate, citric acid, polyglycol 300, sodium phosphate, cetyl alcohol, stearyl alcohol, isopropyl myristate and sodium benzoate.