Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors

Abstract

The present invention provides methods for treating cancer using combinations of bromodomain and extra-terminal (BET) protein inhibitors and certain chemotherapeutic drugs.

1 - 3 . (canceled) 
     
     
         4 . A method of treating neoplasia comprising:
 administering to a subject in need thereof JQ1 and/or its analog in combination with an anti-apoptotic agent in an amount effective to treat the neoplasia.   
     
     
         5 . The method of  claim 4 , wherein the anti-apoptotic agent is selected from the group consisting of ABT263, ABT199, ABT737, and obatoclax. 
     
     
         6 . The method of  claim 4 , wherein JQ1 and/or its analog is administered separately, sequentially or simultaneously with the anti-apoptotic agent. 
     
     
         7 - 11 . (canceled) 
     
     
         12 . The method of  claim 4 , wherein the subject is a mammal. 
     
     
         13 . The method  claim 12 , wherein the subject is a human patient. 
     
     
         14 . The method of  claim 4 , wherein the subject has neoplasia selected from the group consisting of selected from the group consisting of lung cancer, lymphomas including diffuse large B-cell lymphoma and Burkitt's lymphoma, prostate cancer, basal cell carcinoma, biliary tract cancer, bladder cancer, bone cancer, brain cancer, CNS cancer, breast cancer, cervical cancer, choriocarcinoma, colon cancer, rectum cancer, connective tissue cancer, cancer of the digestive system, endometrial cancer, esophageal cancer, eye cancer, cancer of the head and neck, gastric cancer, intra-epithelial neoplasm, kidney cancer, larynx cancer, leukemia, liver cancer, lung cancer, hematologic neoplasias, melanoma, myeloma, neuroblastoma, oral cavity cancer, ovarian cancer, pancreatic cancer, retinoblastoma, rhabdomyosarcoma, rectal cancer, renal cancer, cancer of the respiratory system, sarcoma, skin cancer, stomach cancer, testicular cancer, thyroid cancer, uterine cancer, and cancers of the urinary system. 
     
     
         15 . The method of  claim 14 , wherein the neoplasia is lung cancer. 
     
     
         16 . The method of  claim 14 , wherein the neoplasia is diffuse large B-cell lymphoma. 
     
     
         17 . The method of  claim 14 , wherein the neoplasia is Burkitt's lymphoma. 
     
     
         18 . The method of  claim 4 , further comprising treating the subject with an additional anti-neoplasia therapy. 
     
     
         19 . The method of  claim 18 , wherein the additional anti-neoplasia therapy is surgery, radiation therapy, chemotherapy, gene therapy, DNA therapy, viral therapy, RNA therapy, adjuvant therapy, immunotherapy or a combination thereof. 
     
     
         20 . (canceled) 
     
     
         21 . (canceled) 
     
     
         22 . (canceled)