Fibrinogen composition, method and wound articles

Abstract

Disclosed is a fibrinogen composition. The fibrinogen composition comprises denatured fibrinogen hydrogel having a fibrinogen concentration ranging from 0.1 to 15 wt.-% and a fibrinogen hydrogel forming salt at a concentration less than a threshold concentration to form the fibrinogen hydrogel. In some examples, the fibrinogen composition is dehydrated denatured fibrinogen hydrogel, where the fibrinogen composition comprises salt at a concentration no greater than 20 wt.-%.

What is claimed is: 
     
         1 . A fibrinogen composition comprising
 denatured fibrinogen hydrogel having a fibrinogen concentration ranging from 0.1 to 15 wt.-%;   fibrinogen hydrogel forming salt at a concentration less than a threshold concentration to form the fibrinogen hydrogel.   
     
     
         2 . The fibrinogen composition of  claim 1 , wherein the fibrinogen composition comprises at least 50 wt.-% water. 
     
     
         3 . The fibrinogen composition of  claim 1 , wherein the fibrinogen hydrogel forming salt concentration is less than 0.45 wt-% of the fibrinogen composition. 
     
     
         4 . The fibrinogen composition of  claim 1 , wherein the fibrinogen hydrogel forming salt comprises sodium citrate optionally in combination with sodium chloride. 
     
     
         5 . The fibrinogen composition of  claim 1 , further comprising a plasticizer. 
     
     
         6 . The fibrinogen composition of  claim 5  wherein the plasticizer comprises a sugar alcohol, an alkane diol, or a combination thereof. 
     
     
         7 . The fibrinogen composition of  claim 1 , further comprising a carrier material in an amount ranging from 0.1 to about 50 wt.-%. 
     
     
         8 . The fibrinogen composition of  claim 7  wherein the carrier material comprises a water-soluble polymer. 
     
     
         9 . The fibrinogen composition of  claim 8 , wherein the water-soluble polymer comprises polymerized units of N-vinyl lactam polymer. 
     
     
         10 . The fibrinogen composition of  claim 7 , wherein the carrier material further comprises a swelling agent. 
     
     
         11 . The fibrinogen composition of  claim 1 , wherein the fibrinogen composition is at least partially dehydrated. 
     
     
         12 . A fibrinogen composition comprising
 dehydrated denatured fibrinogen hydrogel;   wherein the fibrinogen composition comprises salt at a concentration no greater than 20 wt.-%.   
     
     
         13 . The fibrinogen composition of  claim 12 , wherein the fibrinogen composition comprises at least 5 wt.-% fibrinogen. 
     
     
         14 . The fibrinogen composition of  claim 12 , wherein the fibrinogen composition comprises less than 50 wt.-% water. 
     
     
         15 . The fibrinogen composition of  claim 12 , wherein the salt concentration is less than 15, 10, or 5 wt.-% of the fibrinogen composition. 
     
     
         16 . The fibrinogen composition of  claim 12 , further comprising a plasticizer. 
     
     
         17 . The fibrinogen composition of  claim 12 , further comprising a carrier material. 
     
     
         18 . The fibrinogen composition of  claim 17 , wherein the fibrinogen composition is interdispersed with 0.5 to 99 wt.-% of the carrier material. 
     
     
         19 . The fibrinogen composition of  claim 17 , wherein the fibrinogen composition is disposed on the carrier material. 
     
     
         20 . The fibrinogen composition of  claim 17 , wherein the carrier material comprises a water-soluble polymer.