Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor

Abstract

The present invention also relates to intermediates used in the processes, and their preparation. The present invention also relates to salts of compounds of Formula (I) and pharmaceutical compositions thereof.

1 - 40 . canceled 
     
     
         41 . A process for preparing a salt of a compound of Formula (I): 
       
         
           
           
               
               
           
         
         wherein: 
         R 1  is halogen; 
         comprising reacting said compound of Formula (I) with a salt-forming acid to form said salt of a compound of Formula (I). 
       
     
     
         42 . The process according to  claim 41 , wherein said compound of Formula (I) is the S enantiomer. 
     
     
         43 . The process according to  claim 41  or  42 , wherein said salt of a compound of Formula (I) is the hydrochloride salt. 
     
     
         44 . The process according to  claim 41  or  42 , wherein R 1  is chloro. 
     
     
         45 . The process according to  claim 41  or  42 , wherein said reacting said compound of Formula (I) with a salt-forming acid is carried out in a salt-forming solvent. 
     
     
         46 . The process according to  claim 41  or  42 , wherein said reacting said compound of Formula (I) with a salt-forming acid is carried out at a temperature of about −10 ° C. to about reflux temperature. 
     
     
         47 . The process according to  claim 41  or  42 , wherein said salt-forming acid is hydrochloric acid.