Novel Thienopyrimidones

Abstract

This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.

1 . A compound according to formula (I) 
       
         
           
           
               
               
           
         
       
       wherein
 A is selected from the group consisting of phenyl, naphthyl, thiophenyl, benzothiophenyl at and benzofuranyl, each optionally substituted with one or two members selected from the group consisting of H, F, Cl, Br, C 1-4 -alkyl, F 1-3 -fluoro-C 1-4 -alkyl, —CN, —OCH 3 , cyclopropyl, and cyclobutyl, 
 or 
 A is selected from 
 
       
         
           
           
               
               
           
         
       
       and
 R 1  is selected from H, C 1-4 -alkyl, F 1-3 -fluoro-C 1-4 -alkyl, C 1-4 -alkyl-OH or C 1-4 -alkyl-CN; 
 R 2  is selected from C 1-2 -alkyl or Cl; 
 or R 1  and R 2  are each CH 2  joined via a bond forming a 6-membered ring; and 
 R 3  is selected from H, or Ci-4-alkyl; 
 
       or pharmaceutically acceptable salt thereof. 
     
     
         2 . The compound of formula (I) according to  claim 1 , wherein A is selected from the group consisting of phenyl, thiophenyl and benzofuranyl, each optionally substituted with one or two members selected from the group consisting of H, F, Cl, Br, C 1-4 -alkyl, F 1-3 -fluoro-C 1-4 -alkyl, CN, OCH 3 , cyclopropyl, and cyclobutyl,
 or   A is selected from   
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salt thereof. 
     
     
         3 . The compound of formula (I) according to  claim 1 , wherein A is selected from the group consisting of phenyl, thiophenyl and benzofuranyl, optionally substituted with one or two members selected from the group consisting of H, F, Br, Cl, and CH 3 ;
 or   A is:   
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salt thereof. 
     
     
         4 . The compound of formula (I) according to  claim 1 , wherein A is selected from the group consisting of 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salt thereof. 
     
     
         5 . The compound of formula (I) according to  claim 1 , wherein R 1  is selected from the group consisting of H and C 1-4 -alkyl; or pharmaceutically acceptable salt thereof. 
     
     
         6 . The compound of formula (I) according to  claim 1 , wherein R 2  is CH 3  or Cl; or pharmaceutically acceptable salt thereof. 
     
     
         7 . The compound of formula (I) according to  claim 1 , wherein R 3  is H or CH 3 ; or pharmaceutically acceptable salt thereof. 
     
     
         8 . The compound of formula (I) according to  claim 1 , selected from the group consisting of 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salt thereof. 
     
     
         9 . The compound of formula (I) according to  claim 1 , selected from the group consisting of 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salt thereof. 
     
     
         10 . A pharmaceutically acceptable salt of a compound according to  claim 1 . 
     
     
         11 . A pharmaceutical composition comprising at least one compound of formula I according to  claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients. 
     
     
         12 . A method for treating or preventing an inflammatory airway disease, a fibrotic disease or cough comprising administering to a patient having such disease or cough an effective amount of a compound according to  claim 1  or a pharmaceutically acceptable salt thereof. 
     
     
         13 . A method according to  claim 12 , wherein the patient has idiopathic pulmonary fibrosis (IPF) or cough.