Compstatin analogs for treatment of neuropathic pain

Abstract

In some aspects, the present invention provides methods of treating a subject in need of treatment for neuropathic pain, the method comprising administering a compstatin analog to the subject. In some embodiments, the compstatin analog is administered parenterally, e.g., intravenously.

1 . A method of treating a subject in need of treatment for neuropathic pain, the method comprising administering a compstatin analog to the subject. 
     
     
         2 . The method of  claim 1 , wherein the compstatin analog is administered intravenously. 
     
     
         3 . The method of  claim 1 , wherein the activity of the compstatin analog is at least 100 times as great as the activity of compstatin as measured in an in vitro assay. 
     
     
         4 . The method of  claim 1 , wherein the compstatin analog is a compound that comprises a cyclic peptide having a core sequence of X′aa-Gln-Asp-Xaa-Gly (SEQ ID NO: 3), where X′aa and Xaa are selected from Trp and analogs of Trp. 
     
     
         5 .- 20 . (canceled) 
     
     
         21 . The method of  claim 1 , further comprising: administering a conventional treatment for neuropathic pain to the subject. 
     
     
         22 . A composition comprising a compstatin analog and a second agent useful for treating neuropathic pain. 
     
     
         23 . The composition of  claim 22 , wherein the compstatin analog is a compound that comprises a cyclic peptide having a core sequence of X′aa-Gln-Asp-Xaa-Gly (SEQ ID NO: 3), where X′aa and Xaa are selected from Trp and analogs of Trp. 
     
     
         24 . The composition of  claim 22 , wherein the second agent is an antidepressant, anticonvulsant, NMDA antagonist, topical anesthetic, opioid analgesic, or sodium channel blocker. 
     
     
         25 . A method of treating a subject in need of treatment for neuropathic pain, the method comprising administering the composition of  claim 22  to the subject. 
     
     
         26 . A method of treating a subject in need of treatment for neuropathic pain, the method comprising administering a compstatin analog and a second agent useful for treating neuropathic pain to the subject. 
     
     
         27 . The method of  claim 26 , wherein the compstatin analog is a compound that comprises a cyclic peptide having a core sequence of X′aa-Gln-Asp-Xaa-Gly (SEQ ID NO: 3), where X′aa and Xaa are selected from Trp and analogs of Trp. 
     
     
         28 . The method of  claim 26 , wherein the second agent is an antidepressant, anticonvulsant, NMDA antagonist, topical anesthetic, opioid analgesic, or sodium channel blocker. 
     
     
         29 . The method of  claim 26 , wherein the compstatin analog and the second agent are administered in different compositions. 
     
     
         30 . The method of  claim 26 , wherein the compstatin analog and the second agent are administered by different routes.