Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof

Abstract

The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.

1 - 15 . (canceled) 
     
     
         16 . A method of reducing triglycerides in a subject having baseline triglyceride levels of at least about 250 mg/dl, the method comprising administering to the subject mipomersen and eicosapentaenoic acid. 
     
     
         17 . The method of  claim 16 , wherein the eicosapentaenoic acid and the mipomersen are present in a single dosage form. 
     
     
         18 . The method of  claim 16 , wherein the mipomersen is in a dosage form separate from the eicosapentaenoic acid. 
     
     
         19 . The method of  claim 16 , wherein a cholesterol level is reduced in the subject. 
     
     
         20 . The method of  claim 19 , wherein the cholesterol level is selected from the group consisting of: HDL-C, LDL-C, non-HDL-C, and VLDL-C. 
     
     
         21 . The method of  claim 16 , wherein the eicosapentaenoic acid is present in a pharmaceutical composition and the eicosapentaenoic acid comprises at least about 80 wt % of all fatty acids in the pharmaceutical composition. 
     
     
         22 . The method of  claim 21 , wherein the eicosapentaenoic acid comprises at least about 96 wt. % of all omega-3 fatty acids in the pharmaceutical composition.