Electronic devices and liquids for aerosolizing and inhaling therewith

Abstract

An electronic device includes a mouthpiece, a bladder, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the bladder. The mouthpiece, the bladder, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the bladder. A liquid-filled cartridge also is disclosed for use with an electronic device for delivery of a substance into a body through respiration includes a liquid container; and a liquid contained within the container for aerosolizing and inhaling by a person using the electronic device. The liquid includes a plurality of nanoparticles in a nanoemulsion, the nanoparticles including the encapsulation of the substance to be delivered into the body through respiration. The nanoemulsion preferably is produced using a microfluidizing machine.

1 - 18 . (canceled) 
     
     
         19 . A liquid-filled cartridge for use with an electronic device for delivery of a substance into a body through respiration, comprising:
 (a) a liquid container; and   (b) a liquid for aerosolizing and inhaling by a person using the electronic device, the liquid being contained within the liquid container and comprising a nanoemulsion, each of a plurality of nanoparticles of the nanoemulsion comprising an encapsulation of the substance to be delivered into the body through respiration.   
     
     
         20 . The liquid-filled cartridge of  claim 19 , wherein the liquid is an oil-in-water nanoemulsion. 
     
     
         21 . The liquid-filled cartridge of  claim 19 , wherein each nanoparticle is a micelle. 
     
     
         22 . The liquid-filled cartridge of  claim 19 , wherein each nanoparticle is a liposome. 
     
     
         23 . The liquid-filled cartridge of  claim 19 , wherein the substance is encapsulated by a polymer. 
     
     
         24 . The liquid-filled cartridge of  claim 19 , wherein the substance is encapsulated by a surfactant. 
     
     
         25 . The liquid-filled cartridge of  claim 24 , wherein the surfactant comprises high purity polyoxyethylene sorbitan monooleate. 
     
     
         26 . The liquid-filled cartridge of  claim 19 , wherein the encapsulated substance comprises tetrahydrocannabinol. 
     
     
         27 . (canceled) 
     
     
         28 . The liquid-filled cartridge of  claim 19 , wherein the encapsulated substance comprises tetrahydrocannabinol and cannabidiol. 
     
     
         29 . The liquid-filled cartridge of  claim 19 , wherein the encapsulated substance comprises a pharmaceutical compound. 
     
     
         30 . The liquid-filled cartridge of  claim 19 , wherein the encapsulated substance comprises nicotine. 
     
     
         31 . The liquid-filled cartridge of  claim 19 , wherein the nanoparticles are dispersed within an aqueous solution. 
     
     
         32 . The liquid-filled cartridge of  claim 31 , wherein the aqueous solution comprises a saline. 
     
     
         33 . The liquid-filled cartridge of  claim 32 , wherein the aqueous solution comprises sodium chloride. 
     
     
         34 . The liquid-filled cartridge of  claim 33 , wherein the nanoparticles are dispersed within an aqueous solution of 0.9% sodium chloride. 
     
     
         35 . The liquid-filled cartridge of  claim 19 , wherein a pH of the liquid is between about 5.5 and about 8. 
     
     
         36 . The liquid-filled cartridge of  claim 19 , wherein a pH of the liquid is between about 6.5. 
     
     
         37 . The liquid-filled cartridge of  claim 19 , wherein a molecular ratio of the encapsulated substance to an encapsulating agent of the nanoparticle is between about 0.1:1 to about 10:1. 
     
     
         38 . The liquid-filled cartridge of  claim 19 , wherein a polydispersity index measurement of the nanoemulsion is less than 0.3. 
     
     
         39 - 49 . (canceled) 
     
     
         50 . The liquid-filled cartridge of  claim 19 , wherein the liquid container comprises a bladder containing between about 1 ml and 3 ml of the liquid and a mesh assembly comprising a mesh material and a piezoelectric material, which mesh material is configured to vibrate when the piezoelectric material is actuated whereby the liquid is aerosolized when the mesh material contacts the liquid of the liquid container; wherein the cartridge is configured to mount onto an end of a base housing of an electronic device and electronically couple with circuitry and a power supply for actuating the mesh assembly, the cartridge forming the mouthpiece of the electronic device.