Nanodiamond particles and related devices and methods

Abstract

Nanodiamond particles and related devices and methods, such as nanodiamond particles for the detection and/or quantification of analytes, are generally described. In some embodiments, the device comprises a plurality of nanodiamond particles and a species bound to the nanodiamond particles. In certain embodiments, the plurality of nanodiamond particles may be exposed to a sample suspected of containing an analyte. In some cases, the analyte may bind to the species such that the presence of the analyte in the sample may be detected. In some embodiments, the devices, systems, and methods described herein are useful for the detection of an analyte in a sample obtained from a subject for, for example, diagnostic purposes. In some cases, the systems, devices, and methods described herein may be useful for diagnosing, prevent, treating, and/or managing a disease or bodily condition. In an exemplary embodiment, such systems, devices, and methods described herein may be useful for detecting and/or quantifying the presence of a virus (e.g., ebola) in a subject and/or a sample obtained from the subject.

1 . A diagnostic agent, said agent comprising a fluorescent nanodiamond particle chemically bonded to a polypeptide and/or polynucleotide. 
     
     
         2 . The diagnostic agent of  claim 1 , wherein the polypeptide is a disintegrin. 
     
     
         3 .- 4 . (canceled) 
     
     
         5 . The diagnostic agent of  claim 1 , wherein the fluorescent nanodiamond particle and the polypeptide are covalently bonded. 
     
     
         6 .- 31 . (canceled) 
     
     
         32 . A diagnostic agent as in  claim 1 , wherein the disintegrin is Bitistatin. 
     
     
         33 . (canceled) 
     
     
         34 . A diagnostic agent for detection of thrombotic events in a human or non-human animal, said agent comprising a fluorescent nanodiamond particle chemically bonded to disintegrin Bitistatin (Bt). 
     
     
         35 .- 36 . (canceled) 
     
     
         37 . The diagnostic agent of  claim 34 , wherein the fluorescent nanodiamond particle and the Bt are covalently bonded. 
     
     
         38 .- 46 . (canceled)