Methods for treating pulmonary fibrosis

Abstract

The present invention provides a method of using arylpiperazine derivatives for treating pulmonary fibrosis. The method comprises a step of administering to a pulmonary fibrosis patient in need thereof an effective amount of a compound of Formula 1, which is an arylpiperazine derivative.

What is claimed is: 
     
         1 . A method of treating pulmonary fibrosis in a subject, the method comprising administering to a subject suffering from pulmonary fibrosis an effective amount of a compound having the following formula, 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt, racemate, or diastereomeric mixture thereof. 
       
     
     
         2 . The method according to  claim 1 , wherein the compound is in a form of a hydrochloride salt. 
     
     
         3 . The method according to  claim 1 , wherein one or more hydrogens of the compounds are optionally substituted with  2 H (deuterium). 
     
     
         4 . The method according to  claim 1 , wherein the compound is administered in a pharmaceutical composition comprising a pharmaceutically acceptable carrier, excipient, or diluent. 
     
     
         5 . The method according to  claim 1 , wherein the compound is orally administered. 
     
     
         6 . The method according to  claim 1 , which treats idiopathic pulmonary fibrosis. 
     
     
         7 . The method according to  claim 1 , which treats pulmonary fibrosis in a subject with chronic obstructive pulmonary disease (COPD). 
     
     
         8 . The method according to  claim 1 , which treats pulmonary fibrosis in a subject with sickle cell disease (SCD). 
     
     
         9 . The method according to  claim 1 , which treats pulmonary fibrosis in a subject with scleroderama. 
     
     
         10 . The method according to  claim 1 , which treats pulmonary fibrosis in a subject with lung cancer.