US2021138073A1PendingUtilityA1

Osteostimulating elastomeric bone filling compositions

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Assignee: SECANT GROUP LLCPriority: Jan 31, 2018Filed: Jan 21, 2021Published: May 13, 2021
Est. expiryJan 31, 2038(~11.6 yrs left)· nominal 20-yr term from priority
Inventors:Jeremy J. HarrisCharles Brendan NicholsonPeter D. GabrieleJared ElyBrian Ginn
A61P 19/00C08L 67/00A61L 27/18C08J 3/12A61L 27/48A61K 47/34A61L 27/56C08G 63/12A61L 24/06A61L 2430/02A61L 2400/08C08J 2367/02A61K 47/593C08K 3/013
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Claims

Abstract

A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of treating a bone defect, the method comprising:
 molding a bone filling composite and placing the bone filling composite in the bone defect;   wherein the bone filling composite comprises a bone filler comprising microparticles of at least one elastomeric material, a carrier material comprising a poly(glycerol sebacate) resin, and a biologic medium.   
     
     
         2 . The method of  claim 1 , wherein the biologic medium is selected from the group consisting of blood, serum, demineralized bone matrix, bone chips, bone morphogenic proteins, and combinations thereof. 
     
     
         3 . The method of  claim 1 , wherein the carrier material further comprises a material selected from the group consisting of a polypeptide, a polysaccharide, a glycosaminoglycan, a hydrogel, and combinations thereof. 
     
     
         4 . The method of  claim 1 , wherein the microparticles comprise thermoset poly(glycerol sebacate). 
     
     
         5 . The method of  claim 1 , wherein the molding comprises mixing the bone filler, the carrier material, and the biologic medium to form the bone filling composite. 
     
     
         6 . The method of  claim 5 , wherein the molding occurs before the placing. 
     
     
         7 . The method of  claim 1 , wherein the molding comprises forming a sheet of the bone filling composite. 
     
     
         8 . A bone filling composite comprising:
 a bone filler comprising microparticles of at least one elastomeric material;   a carrier material comprising a poly(glycerol sebacate) resin; and   a biologic medium.   
     
     
         9 . The bone filling composite of  claim 8 , wherein the biologic medium is selected from the group consisting of blood, serum, demineralized bone matrix, bone chips, bone morphogenic proteins, and combinations thereof. 
     
     
         10 . The bone filling composite of  claim 8 , wherein the carrier material further comprises a material selected from the group consisting of a polypeptide, a polysaccharide, a glycosaminoglycan, a hydrogel, and combinations thereof. 
     
     
         11 . The bone filling composite of  claim 8 , wherein the microparticles comprise thermoset poly(glycerol sebacate).

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