Mechanism of action

Abstract

The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

1 - 20 . (canceled) 
     
     
         21 . A compound of formula (5), or a pharmaceutically acceptable salt or solvate thereof: 
       
         
           
           
               
               
           
         
       
     
     
         22 . A complex comprising a trimeric protein that is a tumor necrosis factor (TNF) superfamily member and the compound of  claim 21 . 
     
     
         23 . (canceled) 
     
     
         24 . A method of treating and/or preventing a disorder selected from an autoimmune, an inflammatory, a neurological, a neurodegenerative, a pain, a nociceptive, and a cardiovascular disorders in a subject in need thereof, comprising administering the compound of  claim 21  to the subject. 
     
     
         25 . The method of  claim 24 , wherein rheumatoid arthritis, Crohn's disease, psoriasis, systemic lupus erythematosus, Alzheimer's disease, Parkinson's disease or epilepsy is treated and/or prevented. 
     
     
         26 . A pharmaceutical composition comprising the compound of  claim 21  and a pharmaceutically acceptable carrier. 
     
     
         27 . A method of treating and/or preventing a disorder selected from an autoimmune, an inflammatory, a neurological, a neurodegenerative, a pain, a nociceptive, and a cardiovascular disorder in a subject in need thereof, comprising administering the complex of  claim 22  to the subject. 
     
     
         28 . A pharmaceutical composition comprising the complex of  claim 22  and a pharmaceutically acceptable carrier. 
     
     
         29 . The method of  claim 27 , wherein rheumatoid arthritis, Crohn's disease, psoriasis, systemic lupus erythematosus, Alzheimer's disease, Parkinson's disease or epilepsy is treated and/or prevented.