Fused bicyclic compounds for the treatment of disease

Abstract

Described herein are fused bicyclic compounds, compositions, and methods for their use for the treatment of disease.

1 - 85 . (canceled) 
     
     
         86 . A compound having the structure: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         87 . The compound according to  claim 86  having the structure: 
       
         
           
           
               
               
           
         
       
     
     
         88 . A pharmaceutical composition comprising a pharmaceutically acceptable diluent, excipient or binder, and a compound of  claim 86 ; or a pharmaceutically acceptable salt thereof. 
     
     
         89 . A method of treating a disease, disorder or condition in a mammal that would benefit from farnesoid X receptor (FXR) agonism comprising administering to the mammal a compound, or a pharmaceutically acceptable salt thereof, according to  claim 86 , wherein the disease, disorder or condition is selected from nonalcoholic steatohepatitis (NASH), hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, dyslipidemia, lipodystrophy, atherosclerosis, Syndrome X, diabetes mellitus, type II diabetes, insulin insensitivity, hyperglycemia, cholestasis and obesity. 
     
     
         90 . The method of  claim 89 , wherein the disease, disorder or condition in a mammal is nonalcoholic steatohepatitis (NASH).