Systems and methods for heart valve therapy

Abstract

Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Some embodiments of prosthetic mitral valves described herein include an anchor portion that couples the prosthetic mitral valve to the anatomy near the native mitral valve, and a valve portion that is mateable with the anchor portion.

What is claimed is: 
     
         1 . A prosthetic mitral valve system comprising:
 a valve assembly comprising an expandable valve frame and an occluder attached to the expandable valve frame; and   an anchor assembly comprising an expandable anchor frame that defines a longitudinal axis, the anchor assembly configured to selectively couple with the valve assembly, the expandable anchor frame comprising a plurality of arched atrial holding features,   wherein, while the expandable anchor frame is in an expanded configuration, each arched atrial holding feature of the plurality of arched atrial holding features extends transversely outward in relation to the longitudinal axis.   
     
     
         2 . The prosthetic mitral valve system of  claim 1 , wherein the plurality of arched atrial holding features comprises three arched atrial holding features. 
     
     
         3 . The prosthetic mitral valve system of  claim 1 , wherein, while the anchor assembly is coupled to a native mitral valve, each arched atrial holding feature of the plurality of arched atrial holding features is positioned directly adjacent to, or spaced apart just superior to, an annulus of the native mitral valve. 
     
     
         4 . The prosthetic mitral valve system of  claim 1 , wherein the expandable anchor frame comprises:
 a centrally located hub;   a first elongate element extending from the hub, the first elongate element including a first sub-annular foot;   a second elongate element extending from the hub, the second elongate element including a second sub-annular foot;   a third elongate element extending from the first elongate element, the third elongate element including a third sub-annular foot; and   a fourth elongate element extending from the second elongate element, the fourth elongate element including a fourth sub-annular foot,   wherein, while the anchor assembly is coupled to a native mitral valve, each of the first foot, the second foot, the third foot, and the fourth foot are positioned within a sub-annular gutter of the native mitral valve.   
     
     
         5 . The prosthetic mitral valve system of  claim 4 , wherein the expandable anchor frame further comprises a systolic anterior motion containment member that is configured to be at least partially disposed behind an anterior leaflet of a native mitral valve while the anchor assembly is coupled to the native mitral valve. 
     
     
         6 . The prosthetic mitral valve system of  claim 5 , wherein the systolic anterior motion containment member extends from the first elongate element and the second elongate element. 
     
     
         7 . The prosthetic mitral valve system of  claim 4 , wherein the hub is located at a distal end of the expandable anchor frame. 
     
     
         8 . The prosthetic mitral valve system of  claim 4 , wherein the hub is threaded for releasable attachment with a delivery device. 
     
     
         9 . The prosthetic mitral valve system of  claim 1 , wherein: the expandable valve frame comprises three valve frame lobes disposed on a proximal end portion of the expandable valve frame; the expandable anchor frame comprises three anchor frame lobes disposed on a proximal end portion of the expandable anchor frame; and wherein, while the valve assembly and the anchor assembly are coupled, each valve frame lobe of the three valve frame lobes is aligned with a respective anchor frame lobe of the three anchor frame lobes. 
     
     
         10 . The prosthetic mitral valve system of  claim 1 , further comprising a control wire slidably engaged with the expandable anchor frame at a plurality of engagement locations at a mid-body region along the longitudinal axis of the expandable anchor frame, the control wire being manipulable to increase and decrease a diameter of the expandable anchor frame during implantation of the anchor assembly. 
     
     
         11 . The prosthetic mitral valve system of  claim 10 , wherein the control wire is removable from the expandable anchor frame to expand the anchor frame while the valve assembly is at least one of decoupled from the anchor assembly and remains in a collapsed configuration. 
     
     
         12 . The prosthetic mitral valve system of  claim 10 , wherein the control wire is removably and slidably engaged with at least two engagement locations at the mid-body region of the expandable anchor frame. 
     
     
         13 . The prosthetic mitral valve system of  claim 10 , wherein the control wire is a first control wire, and further comprising a second control wire slidably engaged with the expandable anchor frame at a proximal end region of the expandable anchor frame. 
     
     
         14 . The prosthetic mitral valve system of  claim 13 , wherein the second control wire is removably and slidably engaged with at least two engagement locations at the proximal end region of the expandable anchor frame, the second end wire being removable from the expandable anchor frame independently and separately from the first control wire. 
     
     
         15 . A prosthetic mitral valve system comprising:
 a valve assembly comprising an expandable valve frame and an occluder attached to the expandable valve frame; and   an anchor assembly comprising an expandable anchor frame that defines a longitudinal axis, the anchor assembly configured to selectively couple with the valve assembly, the expandable anchor frame comprising at least three arched atrial holding features,   wherein, while the expandable anchor frame is in an expanded configuration, each arched atrial holding feature of the at least three arched atrial holding features extends transversely outward in relation to the longitudinal axis, and   wherein, while the anchor assembly is coupled to a native mitral valve, each arched atrial holding feature of the at least three arched atrial holding features is positioned directly adjacent to, or spaced apart just superior to, an annulus of the native mitral valve.   
     
     
         16 . The prosthetic mitral valve system of  claim 15 , wherein the expandable anchor frame comprises:
 a centrally located hub;   a first elongate element extending from the hub, the first elongate element including a first sub-annular foot;   a second elongate element extending from the hub, the second elongate element including a second sub-annular foot;   a third elongate element extending from the first elongate element, the third elongate element including a third sub-annular foot; and   a fourth elongate element extending from the second elongate element, the fourth elongate element including a fourth sub-annular foot,   wherein, while the anchor assembly is coupled to a native mitral valve, each of the first foot, the second foot, the third foot, and the fourth foot are positioned within a sub-annular gutter of the native mitral valve.   
     
     
         17 . The prosthetic mitral valve system of  claim 16 , wherein the expandable anchor frame further comprises a systolic anterior motion containment member that is configured to be at least partially disposed behind an anterior leaflet of the native mitral valve while the anchor assembly is coupled to the native mitral valve. 
     
     
         18 . The prosthetic mitral valve system of  claim 17 , wherein the systolic anterior motion containment member extends from the first elongate element and the second elongate element. 
     
     
         19 . The prosthetic mitral valve system of  claim 15 , wherein: the expandable valve frame comprises three valve frame lobes disposed on a proximal end portion of the expandable valve frame; the expandable anchor frame comprises three anchor frame lobes disposed on a proximal end portion of the expandable anchor frame; and wherein, while the valve assembly and the anchor assembly are coupled, each valve frame lobe of the three valve frame lobes is aligned with a respective anchor frame lobe of the three anchor frame lobes. 
     
     
         20 . The prosthetic mitral valve system of  claim 15 , further comprising a control wire slidably engaged with the expandable anchor frame at a plurality of engagement locations at a mid-body region along the longitudinal axis of the expandable anchor frame, the control wire being manipulable to increase and decrease a diameter of the expandable anchor frame during implantation of the anchor assembly.