US2021161875A1PendingUtilityA1

Topical retinoid compositions

70
Assignee: Dr Reddys Laboratories LtdPriority: Jul 13, 2015Filed: Feb 8, 2021Published: Jun 3, 2021
Est. expiryJul 13, 2035(~9 yrs left)· nominal 20-yr term from priority
Inventors:Sateesh KandavilliFranklin OkumuManish M. BankarSujit Kumar Dolai
A61K 2300/00A61K 2121/00A61Q 19/00A61K 31/7004A61K 31/355A61K 31/203A61K 9/0014A61K 8/671A61K 8/4973A61K 8/4926A61P 17/10A61K 8/49A61K 31/4436A61P 19/00A61Q 19/08A61K 8/678A61Q 19/02A61P 17/00A61K 8/498A61Q 19/10A61C 19/00A61C 19/08A61K 31/352A61K 9/122
70
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Claims

Abstract

The present application relates to topical compositions. In particular, the present application relates to a topical composition comprising retinoid as active agent, and pharmaceutically acceptable excipient(s), and a process of preparing such compositions. Further, the present application relates to method of using topical compositions for the treatment of skin disorders such as acne, rosacea, psoriasis etc.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A topical lotion composition, comprising:
 a) a retinoid compound;   b) an oil phase comprising one or more water immiscible substances;   c) a hydrophilic phase comprising water;   d) a thickener;   e) one or more dermatologically acceptable excipient; and   f) one or more surfactants in the range from about 0.01% w/w to about 10% w/w of the total weight of the composition;   wherein the composition is free of propellant, and wherein the composition has pH from about 4 to about 7.   
     
     
         2 . The topical composition of  claim 1 , wherein said retinoid compound is selected from tretinoin, isotretinoin, acitretin, tazarotene, and adapalene. 
     
     
         3 . The topical composition of  claim 1 , wherein the retinoid compound is tazarotene. 
     
     
         4 . The composition of  claim 1 , wherein the retinoid compound is tretinoin. 
     
     
         5 . The topical composition of  claim 1 , wherein the thickener is selected from carbomers, polyvinyl pyrrolidone, locust gum, polyvinyl alcohol, cross-linked polyacrylate polymer, guar gum, locust bean gum, polysaccharides, cellulose polymers and any combinations thereof. 
     
     
         6 . The topical composition of  claim 1 , wherein the thickener is the range of from 0.01% to 2%. 
     
     
         7 . The topical composition of  claim 1 , wherein the thickener comprises a carbomer. 
     
     
         8 . The composition of  claim 1 , wherein the composition excludes peanut oil. 
     
     
         9 . A topical lotion composition comprising:
 a) a retinoid compound;   b) at least one thickener comprising carbomer;   c) at least one preservative selected from the group consisting of benzyl alcohol, methylparaben, and combinations thereof;   d) an antioxidant comprising butylated hydroxytoluene;   e) a moisturizer comprising glycerin;   f) an emollient comprising mineral oil;   g) a pH adjusting agent comprising trolamine;   h) water; and   i) one or more surfactants in the range from about 0.01% w/w to about 10% w/w of the total weight of the composition;   wherein the composition is free of propellant, and wherein the composition has pH from about 4 to about 7.   
     
     
         10 . The topical composition of  claim 9 , wherein said retinoid compound is selected from tretinoin, isotretinoin, acitretin, tazarotene, and adapalene. 
     
     
         11 . The composition of  claim 1 , wherein the retinoid compound is tretinoin. 
     
     
         12 . The topical composition of  claim 9 , wherein the composition comprises at least about 60% w/w water based on the total weight of the composition. 
     
     
         13 . The composition of  claim 9 , comprising one or more surfactants having a hydrophilic/lipophilic balance (HLB) of more than 10. 
     
     
         14 . The composition of  claim 9 , wherein the surfactants excludes surfactants selected from cetyl alcohol and stearyl alcohol. 
     
     
         15 . The composition of  claim 9 , wherein the composition excludes peanut oil. 
     
     
         16 . The topical composition of  claim 9 , wherein the composition has viscosity in the range of from about 1000 cps to about 50,000 cps, when measured by Brookfield DV-II pro Viscometer with low viscosity spindle no. 4 at 20 rpm. 
     
     
         17 . A topical lotion composition comprising:
 a) a retinoid compound;   b) an oil phase comprising one or more water immiscible substances;   c) a hydrophilic phase comprising water;   d) a thickener; and   e) one or more dermatologically acceptable excipient;   wherein the composition is free of propellant;   wherein the thickener is selected from carbomers, polyvinyl pyrrolidone, locust gum, polyvinyl alcohol, cross-linked polyacrylate polymer, guar gum, locust bean gum, polysaccharides, cellulose polymers and any combinations thereof; and   
       wherein a substantial amount of retinoid compound is in hydrophilic phase. 
     
     
         18 . The topical composition of  claim 17 , wherein said retinoid compound is selected from tretinoin, isotretinoin, acitretin, tazarotene, and adapalene. 
     
     
         19 . The topical composition of  claim 17 , wherein the retinoid compound is suspended in the composition. 
     
     
         20 . The topical composition of  claim 17 , wherein D90 globule size of oil phase is at least 2 microns and less than about 50 microns.

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