US2021163423A1PendingUtilityA1
Certain chemical entities, compositions, and methods
Est. expiryFeb 17, 2035(~8.6 yrs left)· nominal 20-yr term from priority
C07D 401/04C07D 401/12A61P 35/00C07D 239/84C07D 473/32C07D 473/30C07D 403/12A61K 31/495
63
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein
is aryl or heteroaryl;
is selected from a group consisting of:
wherein; a is point of attachment for L and b is point of attachment for G;
X 3 is C—R 3 , or N; X 4 is C—R 4 , or N; X 5 is C—R 5 , or N; X 6 is C—R 19 , or N; X 7 is C—R 20 , or N; X 8 is C—R 21 , or N; Y is O, S, or N—R 22 ;
L is —[(CR 30 R 31 ) x —O—(CR 32 R 33 ) y ] z —, —[(CR 30 R 31 ) x ] z —, —[(CR 30 R 31 )—S—(CR 30 R 31 ) y ] z —, —[(CR 30 R 31 ) x —NR 29 —(CR 30 R 31 ) y ] z —, —[(CR 30 R 31 ) x —CO—(CR 30 R 31 ) y ] z —, —[(CR 30 R 31 ) x —SO 2 —(CR 30 R 31 ) y ] z —, —[(CR 30 R 31 ) x —CO 2 —(CR 30 R 31 ) y ] z —, —[(CR 30 R 31 )—CONR 29 —(CR 30 R 31 ) y ] z —, or —[(CR 30 R 31 ) x —SO 2 NR 29 —(CR 30 R 31 ) y ] z —;
each of R 3 , R 4 , R 5 , R 6 , R 14 , R 15 , R 16 , R 19 , R 20 , R 21 , R 30 , R 31 , R 32 , R 33 , and G is independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl;
R 17 , R 18 , R 22 , and R 29 are independently is independently hydrogen, sulfonyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl;
or R 3 and R 4 , R 4 and R 5 , R 15 and R 16 , R 15 and R 17 , R 20 and R 21 , R 20 and R 22 , or R 21 and R 22 may optionally be joined together with any intervening atoms to form an optionally substituted aryl, heteroaryl, cycloalkyl, or heterocycloalkyl ring;
each Z is independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or E; wherein E is an electrophilic group capable of forming a covalent bond with a nucleophile;
n is 0, 1, 2, 3, 4 or 5; and x, y, or z is independently 0, 1, 2, 3, or 4;
provided that when
G is
wherein
is aryl, heteroaryl, or heterocycloalkyl; m is 0, 1, 2, 3, 4, or 5 and each Q is independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or E; and L is —NH—; then n is 12, 3, 4, or 5, and at least one Z is E.
2 . The compound or pharmaceutically acceptable salt of any one of claim 1 , wherein G iscyano, halo, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl.
3 . The compound or pharmaceutically acceptable salt of claim 2 , wherein G is halo or optionally substituted alkoxy.
4 . The compound or pharmaceutically acceptable salt of claim 2 , wherein G is optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl.
5 . The compound or pharmaceutically acceptable salt of any one of claims 1 - 4 , wherein
is selected from the group consisting of: pyrrolyl, furanyl, thienyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, furazanyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,3,4-oxadiazole, thiadiazolyl, dithiazolyl, tetrazolyl, pyridinyl, pyranyl, thiopyranyl, diazinyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxazinyl, thiazinyl, dioxinyl, dithiinyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, tetrazinyl, and phenyl.
6 . The compound or pharmaceutically acceptable salt of claim 5 , wherein
is selected from the group consisting of: phenyl, pyridinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl, pyrazolyl, isoxazolyl, and thienyl.
7 . The compound or pharmaceutically acceptable salt of claim 6 , wherein
is phenyl or pyridinyl.
8 . The compound or pharmaceutically acceptable salt of claim 6 , wherein
is phenyl.
9 . The compound or pharmaceutically acceptable salt of any one of claims 1 - 8 , wherein L is —[(CR 30 R 31 ) x —NR 29 —(CR 30 R 31 ) y ] z —.
10 . The compound or pharmaceutically acceptable salt of claim 9 , wherein L is —O—, —CH 2 —, —NH—, —S—, —CO—, —CO 2 —, —CONH—, SO 2 —, or —SO 2 NH—.
11 . The compound or pharmaceutically acceptable salt of claim 10 , wherein L is —NH—.
12 . The compound or pharmaceutically acceptable salt of any one of claims 1 - 11 , wherein each Z is independently hydrogen, cyano, halo, optionally substituted amino, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryloxy, optionally substituted heterocycloalkyl, optionally substituted aminocarbonyl, or E.
13 . The compound or pharmaceutically acceptable salt of claim 12 , wherein each Z is independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted heterocycloalkyloxy, optionally substituted heterocycloalkyl, or optionally substituted amino, optionally substituted aminocarbonyl, or E.
14 . The compound or pharmaceutically acceptable salt of claim 13 , wherein n is 1, 2, 3, 4, or 5; and at least one Z is cyano, fluoro, chloro, methoxy, —CONH 2 , 2-methoxyethoxy, 2-(dimethylamino)ethoxy, (1-methylpyrrolidin-3-yl)oxy, (1-methylpiperidin-4-yl)oxy, (1-methylpiperidin-3-yl)oxy, (1-methylazetidin-3-yl)oxy (2-(dimethylamino)ethyl)(methyl)amino, dimethylamino, methyl(1-methylazetidin-3-yl)amino, methyl(1-methylpyrrolidin-3-yl)amino, methyl(1-methylpiperidin-4-yl)amino, optionally substituted morpholinyl, optionally substituted piperazinyl, optionally substituted pyrrolidinyl, optionally substituted piperidinyl, optionally substituted azetidinyl.
15 . The compound or pharmaceutically acceptable salt of claim 13 , wherein n is 1, 2, 3, 4, or 5; and at least one Z is E.
16 . The compound or pharmaceutically acceptable salt of claim 15 , wherein each E is independently an electrophilic group capable of forming a covalent bond with a cysteine residue of a protein.
17 . The compound or pharmaceutically acceptable salt of claim 16 , wherein each E is independently selected from a group consisting of
18 . The compound or pharmaceutically acceptable salt of claim 17 , wherein at least one E is
19 . The compound or pharmaceutically acceptable salt of claim 17 , wherein at least one E is
20 . The compound or pharmaceutically acceptable salt of claim 1 , wherein
is
X 10 is C—R 35 , or N; and
R 34 , R 35 , R 36 , R 37 , and R 38 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or E.
21 . The compound or pharmaceutically acceptable salt of claim 20 , wherein R 34 , R 35 , R 36 , R 37 , and R 38 are independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted heterocycloalkyloxy, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted aminocarbonyl, or E.
22 . The compound or pharmaceutically acceptable salt of claim 21 , wherein R 35 or R 37 is E.
23 . The compound or pharmaceutically acceptable salt of claim 20 , wherein R 34 , R 35 , R 37 , and R 38 are independently hydrogen, cyano, fluoro, chloro, methoxy, or —CONH 2 , and R 36 is optionally substituted morpholinyl, optionally substituted piperazinyl, optionally substituted pyrrolidinyl, optionally substituted piperidinyl, optionally substituted azetidinyl, or substituted amino.
24 . The compound or pharmaceutically acceptable salt of claim 22 , wherein R 36 is
wherein R 28 is hydrogen, sulfonyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl.
25 . The compound or pharmaceutically acceptable salt of claim 24 , wherein R 28 is —C(O)C 1 -C 4 alkyl or C 1 -C 6 alkyl optionally substituted with —OH, halo, C 1 -C 4 alkyl, or —OC 1 -C 4 alkyl.
26 . The compound or pharmaceutically acceptable salt of claim 25 , wherein R 28 is —CH 3 , —COCH 3 , —CH 2 CH 2 OH, —CH 2 CH 2 F, —CH 2 CH 2 OMe, —CH 2 C(CH 3 ) 2 OH, or —CH 2 CH(CH 3 )OH.
27 . The compound or pharmaceutically acceptable salt thereof of claim 1 , having the Formula Ia:
wherein
is optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl;
each Q is independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or E; wherein each E is independently an electrophilic group capable of forming a covalent bond with a nucleophile; and
m is 0, 1, 2, 3, 4, or 5.
28 . The compound or pharmaceutically acceptable salt of claim 27 , wherein
is selected from the group consisting of: phenyl, pyridinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl, pyrazolyl, isoxazolyl, and thienyl.
29 . The compound or pharmaceutically acceptable salt of claim 28 , wherein
is phenyl or pyridinyl.
30 . The compound or pharmaceutically acceptable salt of claim 27 , wherein
is selected from the group consisting of: piperazinyl, morpholinyl, piperidinyl, thiomorpholinyl, pyrrolidinyl, tetrahydrofuranyl, diazepanyl, azetidinyl, oxetanyl, oxiranyl, and aziridinyl.
31 . The compound or pharmaceutically acceptable salt of claim 30 , wherein
is selected from the group consisting of: piperazinyl, morpholinyl, piperidinyl, pyrrolidinyl, tetrahydrofuranyl, and diazepanyl.
32 . The compound or pharmaceutically acceptable salt of claim 31 , wherein
is selected from the group consisting of: piperazinyl, morpholinyl, piperidinyl, and pyrrolidinyl.
33 . The compound or pharmaceutically acceptable salt of any one of claims 26 to 31 , wherein m is 1, 2, or 3; and at least one Q is E.
34 . The compound or pharmaceutically acceptable salt of claim 33 , wherein each E is independently an electrophilic group capable of forming a covalent bond with a cysteine residue of a protein.
35 . The compound or pharmaceutically acceptable salt of claim 34 , wherein each E is independently selected from a group consisting of
36 . The compound or pharmaceutically acceptable salt of claim 35 , wherein at least one E is
37 . The compound or pharmaceutically acceptable salt of claim 35 , wherein at least one E is
38 . The compound or pharmaceutically acceptable salt of claim 27 , wherein
is
X 11 is C—R 27 , or N; and
R 23 , R 24 , R 25 , R 26 , and R 27 are independently, hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl or E;
39 . The compound or pharmaceutically acceptable salt of claim 38 , wherein R 23 , R 24 , R 25 , R 26 , and R 27 are independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted amino, optionally substituted aminocarbonyl, or E.
40 . The compound or pharmaceutically acceptable salt of claim 39 , wherein R 24 , R 25 , or R 26 is E.
41 . The compound or pharmaceutically acceptable salt of claim 1 , having the Formula Ib:
42 . The compound or pharmaceutically acceptable salt of claim 41 , wherein X 3 , X 4 and X 5 are respectively C—R 3 , C—R 4 , and C—R 5 .
43 . The compound or pharmaceutically acceptable salt of claim 41 , wherein X 5 , X 4 and X 3 are respectively N, C—R 4 , and C—R 3 .
44 . The compound or pharmaceutically acceptable salt of claim 41 , wherein X 5 , X 4 and X 3 are respectively C—R 5 , N, and C—R 3 .
45 . The compound or pharmaceutically acceptable salt of claim 41 , wherein X 5 , X 4 and X 3 are respectively C—R 5 , C—R 4 , and N.
46 . The compound or pharmaceutically acceptable salt of claim 41 , wherein X 5 , X 4 and X 3 are respectively N, C—R 4 , and N.
47 . The compound or pharmaceutically acceptable salt of claim 41 , wherein n is 1, 2, 3, 4, or 5; and at least one Z is E.
48 . The compound or pharmaceutically acceptable salt of claim 41 , having the Formula Ic:
49 . The compound or pharmaceutically acceptable salt of claim 48 , wherein R 3 , R 4 , R 6 and R 5 are independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted heterocycloalkyloxy, optionally substituted heterocycloalkyl, optionally substituted amino, or optionally substituted aminocarbonyl.
50 . The compound or pharmaceutically acceptable salt of claim 49 , wherein R 3 , R 4 , R 6 and R 5 are independently hydrogen, cyano, fluoro, chloro, methyl, hydroxymethyl, —CH 2 F, —CONH 2 , or methoxy.
51 . The compound or pharmaceutically acceptable salt of claim 49 , wherein R 3 , R 4 , R 6 and R 5 are independently hydrogen, fluoro, or chloro.
52 . The compound or pharmaceutically acceptable salt of any one of claims 48 to 51 , wherein G is halo or optionally substituted alkoxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl.
53 . The compound or pharmaceutically acceptable salt of claim 52 , wherein G is optionally substituted aryl.
54 . The compound or pharmaceutically acceptable salt of claim 53 , wherein G is halo substituted aryl.
55 . The compound or pharmaceutically acceptable salt of claim 53 , wherein G is optionally substituted phenyl or pyridinyl.
56 . The compound or pharmaceutically acceptable salt of claim 55 , wherein G is halo substituted phenyl or pyridinyl.
57 . The compound or pharmaceutically acceptable salt of claim 52 , wherein G is halo or optionally substituted alkoxy.
58 . The compound or pharmaceutically acceptable salt of any one of claims 48 to 57 , wherein R 34 , R 37 , and R 38 are independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted heterocycloalkyloxy, optionally substituted heterocycloalkyl, optionally substituted amino, or optionally substituted aminocarbonyl.
59 . The compound or pharmaceutically acceptable salt of claim 58 , wherein R 34 , R 37 , and R 38 are independently hydrogen, cyano, fluoro, chloro, methoxy, or —CONH 2 .
60 . The compound or pharmaceutically acceptable salt of any one of claims 48 to 59 , wherein R 36 is optionally substituted alkoxy, optionally substituted heterocycloalkyloxy, optionally substituted heterocycloalkyl, or optionally substituted amino.
61 . The compound or pharmaceutically acceptable salt of claim 60 , wherein R 36 is methoxy, 2-methoxyethoxy, 2-(dimethylamino)ethoxy, (1-methylpyrrolidin-3-yl)oxy, (1-methylpiperidin-4-yl)oxy, (1-methylpiperidin-3-yl)oxy, (1-methylazetidin-3-yl)oxy, (2-(dimethylamino)ethyl)(methyl)amino, dimethylamino, methyl(1-methylazetidin-3-yl)amino, methyl(1-methylpyrrolidin-3-yl)amino, methyl(1-methylpiperidin-4-yl)amino, optionally substituted morpholinyl, optionally substituted piperazinyl, optionally substituted pyrrolidinyl, optionally substituted piperidinyl, or optionally substituted azetidinyl.
62 . The compound or pharmaceutically acceptable salt of any one of claims 48 to 61 , wherein E is
63 . The compound or pharmaceutically acceptable salt of any one of claims 48 to 61 , wherein E is
64 . The compound or pharmaceutically acceptable salt of claim 1 , having the Formula Id:
65 . The compound or pharmaceutically acceptable salt of claim 64 , wherein X 10 is C—R 25 , or N.
66 . The compound or pharmaceutically acceptable salt of claim 64 , wherein X 11 is C—R 27 , or N.
67 . The compound or pharmaceutically acceptable salt of claim 64 , wherein R 34 , R 37 , and R 38 are independently hydrogen, cyano, fluoro, chloro, methoxy, or —CONH 2 , and R 36 is optionally substituted morpholinyl, optionally substituted piperazinyl, optionally substituted pyrrolidinyl, optionally substituted piperidinyl, optionally substituted azetidinyl, or substituted amino.
68 . The compound or pharmaceutically acceptable salt of claim 67 , wherein R 36 is
wherein R 28 is hydrogen, sulfonyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl.
69 . The compound or pharmaceutically acceptable salt of claim 68 , wherein R 28 is —C(O)C 1 -C 4 alkyl or C 1 -C 6 alkyl optionally substituted with —OH, halo, C 1 -C 4 alkyl, or —OC 1 -C 4 alkyl.
70 . The compound or pharmaceutically acceptable salt of claim 69 , wherein R 28 is —CH 3 , —COCH 3 , —CH 2 CH 2 OH, —CH 2 CH 2 F, —CH 2 CH 2 OMe, —CH 2 C(CH 3 ) 2 OH, or —CH 2 CH(CH 3 )OH.
71 . The compound or pharmaceutically acceptable salt of any one of claims 64 - 70 , wherein E is selected from a group consisting of
72 . The compound or pharmaceutically acceptable salt of claim 71 , wherein E is
73 . The compound or pharmaceutically acceptable salt of claim 71 , wherein E is
74 . A compound of Formula Ie:
or a pharmaceutically acceptable salt thereof, wherein:
is aryl or heteroaryl;
is selected from a group consisting of:
wherein a is point of attachment for L and b is point of attachment for
X 6 is C—R 19 , or N;
X 7 is C—R 20 , or N;
X 8 is C—R 21 , or N;
Y is O, S, or N—R 22 ;
L is —[(CR 30 R 31 ) x —O—(CR 32 R 33 ) y ] z —, —[CR 30 R 31 ) x ] z —, —[CR 30 R 31 ) x —S—(CR 30 R 31 ) y ] z —, —[(CR 30 R 31 ) x —NR 29 —(CR 30 R 31 ) y ] z —, —[(CR 30 R 31 ) x —CO—(CR 30 R 31 ) y ] z —, —[(CR 30 R 31 ) x —SO 2 —(CR 30 R 31 ) y ] z —, —[(CR 30 R 31 ) x —CO 2 —(CR 30 R 31 ) y ] z —, —[(CR 30 R 31 ) x —CONR 29 —(CR 30 R 31 ) y ] z —, or —[(CR 30 R 31 ) x —SO 2 NR 29 —(CR 30 R 31 ) y ] z —;
each of R 6 , R 19 , R 20 , R 21 , R 30 , R 31 , R 32 , R 33 is independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl;
R 22 and R 29 are independently hydrogen, sulfonyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl;
or R 20 and R 21 , R 20 and R 22 , or R 21 and R 22 may optionally be joined together with any intervening atoms to form an optionally substituted aryl, heteroaryl, cycloalkyl, or heterocycloalkyl ring;
each Z is independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or E; wherein E is an electrophilic group capable of forming a covalent bond with a nucleophile;
is optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl;
each Q is independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or E; wherein E each is independently an electrophilic group capable of forming a covalent bond with a nucleophile;
m is 0, 1, 2, 3, 4, or 5;
n is 0, 1, 2, 3, 4 or 5; and
each of x, y, or z is independently 0, 1, 2, 3, or 4.
75 . The compound or pharmaceutically acceptable salt of claim 74 , wherein
is:
76 . The compound or pharmaceutically acceptable salt of claim 74 or 75 , having a Formula If:
77 . The compound or pharmaceutically acceptable salt of any one of claims 74 - 76 , wherein L is NH.
78 . The compound or pharmaceutically acceptable salt of any one of claims 74 - 77 , wherein
wherein
X 10 is C—R 35 , or N; and
R 34 , R 35 , R 36 , R 37 , and R 38 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or E.
79 . The compound or pharmaceutically acceptable salt of any one of claims 74 - 77 , wherein
80 . The compound or pharmaceutically acceptable salt of any one of claims 74 - 79 , having a Formula Ig:
81 . The compound or pharmaceutically acceptable salt of any one of claims 78 - 80 , wherein R 34 , R 35 , R 36 , R 37 , and R 38 are independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted heterocycloalkyloxy, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted aminocarbonyl, or E.
82 . The compound or pharmaceutically acceptable salt of any one of claims 78 - 81 , wherein R 3 or R 37 is E.
83 . The compound or pharmaceutically acceptable salt of any one of claims 78 - 81 , wherein R 3 or R 37 is
84 . The compound or pharmaceutically acceptable salt of any one of claims 78 - 81 , wherein, R 35 or R 37 is
85 . The compound or pharmaceutically acceptable salt of any one of claims 78 - 80 , wherein R 34 , R 35 , R 37 , and R 38 are independently hydrogen, cyano, fluoro, chloro, methoxy, or —CONH 2 , and R 36 is optionally substituted morpholinyl, optionally substituted piperazinyl, optionally substituted pyrrolidinyl, optionally substituted piperidinyl, optionally substituted azetidinyl, or substituted amino.
86 . The compound or pharmaceutically acceptable salt of anyone of claims 78 - 80 , wherein R 36 is
wherein R 28 is hydrogen, sulfonyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl.
87 . The compound or pharmaceutically acceptable salt of claim 86 , wherein R 28 is —C(O)C 1 -C 4 alkyl or C 1 -C 6 alkyl optionally substituted with —OH, halo, C 1 -C 4 alkyl, or —OC 1 -C 4 alkyl.
88 . The compound or pharmaceutically acceptable salt of claim 86 , wherein R 28 is —CH 3 , —COCH 3 , —CH 2 CH 2 OH, —CH 2 CH 2 F, —CH 2 CH 2 OMe, —CH 2 C(CH 3 ) 2 OH, or —CH 2 CH(CH 3 )OH.
89 . The compound or pharmaceutically acceptable salt of any one of claims 78 - 80 , wherein X 10 is C—R 35 .
90 . The compound or pharmaceutically acceptable salt of any one of claims 78 - 89 , wherein R 35 is hydrogen, cyano, halo, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl.
91 . The compound or pharmaceutically acceptable salt of any one of claims 78 - 90 , wherein R 35 is hydrogen or halo.
92 . The compound or pharmaceutically acceptable salt of any one of claims 78 - 80 , wherein X 10 is N
93 . The compound or pharmaceutically acceptable salt of any one of claims 74 - 92 , wherein m is 1, 2, 3, 4 or 5 and at least one Q is E.
94 . The compound or pharmaceutically acceptable salt of any one of claims 74 - 93 , wherein each E is independently selected from a group consisting of:
95 . The compound or pharmaceutically acceptable salt of any one of claims 74 - 94 , wherein
is selected from the group consisting of:
wherein each W is independently selected from the group consisting of hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or E; wherein each E is independently an electrophilic group capable of forming a covalent bond with a nucleophile.
96 . The compound or pharmaceutically acceptable salt of claim 95 , wherein W is selected from the group consisting of H, optionally substituted alkyl, and
97 . The compound or pharmaceutically acceptable salt of claim 95 or 96 , wherein W is selected from the group consisting of H, C 1 -C 4 alkyl, and
98 . The compound or pharmaceutically acceptable salt of any one of claims 74 - 92 , wherein
X 11 is C—R 27 , or N; and
R 23 , R 24 , R 25 , R 26 , and R 27 are independently, hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl, or E.
99 . The compound or pharmaceutically acceptable salt of claim 98 , wherein R 23 , R 24 , R 25 , R 26 , and R 27 are independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted amino, optionally substituted aminocarbonyl, or E.
100 . The compound or pharmaceutically acceptable salt of claim 98 or 99 , wherein, R 24 , R 25 , or R 26 is E.
101 . The compound or pharmaceutically acceptable salt of any one of claims 98 - 100 , wherein R 24 , R 25 , or R 26 is
102 . The compound or pharmaceutically acceptable salt of any one of claims 98 - 100 , R 24 , R 25 , or R 26 is
103 . The compound or pharmaceutically acceptable salt of claim 98 , wherein R 23 , R 25 , R 26 , and R 27 are independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted amino, optionally substituted aminocarbonyl, and R 24 is E.
104 . The compound or pharmaceutically acceptable salt of claim 98 , wherein R 23 , R 25 , R 26 , and R 27 are independently hydrogen, cyano, halo, methoxy, or —CONH 2 , and R 24 is E.
105 . The compound or pharmaceutically acceptable salt of claim 98 , wherein R 23 , R 24 , R 26 , and R 27 are independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted amino, optionally substituted aminocarbonyl, and R 25 is E.
106 . The compound or pharmaceutically acceptable salt of claim 98 , R 23 , R 24 , R 26 , and R 27 are independently hydrogen, cyano, halo, methoxy, or —CONH 2 , and R 25 is E.
107 . A compound or pharmaceutically acceptable salt thereof, wherein the compound is chosen from the group consisting of:
N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide (R)—N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide (S)—N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-fluoroethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-ethylpiperazin-1-yl)-2,3-difluorophenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-acetylpiperazin-1-yl)-2,3-difluorophenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-morpholinophenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3,5-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,5-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,6-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3,5-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,5-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,6-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3,5-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,5-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,6-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3,5-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,5-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,6-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide (R)—N-(3-(7-((2-fluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide (S)—N-(3-(7-((2-fluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(4-(2-fluoroethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-ethylpiperazin-1-yl)-2-fluorophenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-acetylpiperazin-1-yl)-2-fluorophenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-morpholinophenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide (R)—N-(3-(7-((3-fluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide (S)—N-(3-(7-((3-fluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(4-(2-fluoroethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-ethylpiperazin-1-yl)-3-fluorophenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-acetylpiperazin-1-yl)-3-fluorophenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-morpholinophenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-((1-methylpiperidin-4-yl)amino)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-((1-methylpiperidin-4-yl)amino)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-((1-methylpiperidin-4-yl)amino)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-((1-methylpiperidin-4-yl)amino)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide (R)—N-(3-(7-((4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide (S)—N-(3-(7-((4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-fluoroethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-acetylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(4-oxo-7-((4-(piperazin-1-yl)phenyl)amino)pyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-morpholinophenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-chloro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-cyano-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methoxyphenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-(hydroxymethyl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 2-((8-(3-acrylamidophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-5-(4-(2-hydroxyethyl)piperazin-1-yl)benzamide N-(3-(7-((3-chloro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)-3-methoxyphenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)-3-(hydroxymethyl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 5-((8-(3-acrylamidophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-2-(4-(2-hydroxyethyl)piperazin-1-yl)benzamide N-(3-(7-((2-chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-cyano-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-(hydroxymethyl)-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 2-((8-(3-acrylamidophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-5-(4-methylpiperazin-1-yl)benzamide N-(3-(7-((3-chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-(hydroxymethyl)-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 5-((8-(3-acrylamidophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-2-(4-methylpiperazin-1-yl)benzamide N-(3-(7-((6-(4-(2-hydroxyethyl)piperazin-1-yl)pyridin-3-yl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((5-(4-(2-hydroxyethyl)piperazin-1-yl)pyridin-2-yl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(6-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(4-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(5-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-3-yl)acrylamide N-(2-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-4-yl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)-4-fluorophenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)-2-fluorophenyl)acrylamide N-(5-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)-2-fluorophenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)-5-fluorophenyl)acrylamide N-(6-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(4-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(5-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-3-yl)acrylamide N-(2-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-3-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-5-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-fluoro-5-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(6-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(4-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(5-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-3-yl)acrylamide N-(2-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-3-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-5-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-fluoro-5-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(6-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(4-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(5-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-3-yl)acrylamide N-(2-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-5-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-fluoro-5-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(6-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(4-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(5-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-3-yl)acrylamide N-(2-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-4-yl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)-4-fluorophenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)-2-fluorophenyl)acrylamide N-(5-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)-2-fluorophenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)-5-fluorophenyl)acrylamide N-(6-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(4-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(5-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-3-yl)acrylamide N-(2-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-3-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-5-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-fluoro-5-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(6-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(4-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(5-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-3-yl)acrylamide N-(2-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-3-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-5-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-fluoro-5-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(6-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(4-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-2-yl)acrylamide N-(5-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-3-yl)acrylamide N-(2-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-3-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(2-fluoro-5-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-fluoro-5-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2-methyl-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2-(hydroxymethyl)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 1-(3-acrylamidophenyl)-7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxo-1,4-dihydropyrimido[4,5-d]pyrimidine-2-carboxamide N-(3-(2-cyano-7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2-methyl-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2-(hydroxymethyl)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 1-(3-acrylamidophenyl)-7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxo-1,4-dihydropyrimido[4,5-d]pyrimidine-2-carboxamide N-(3-(2-cyano-7-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2-methyl-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2-(hydroxymethyl)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 1-(3-acrylamidophenyl)-7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxo-1,4-dihydropyrimido[4,5-d]pyrimidine-2-carboxamide N-(3-(2-cyano-7-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2-methyl-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2-(hydroxymethyl)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 1-(3-acrylamidophenyl)-7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxo-1,4-dihydropyrimido[4,5-d]pyrimidine-2-carboxamide N-(3-(2-cyano-7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-methyl-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-(hydroxymethyl)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 1-(3-acrylamidophenyl)-7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxo-1,4-dihydropyrimido[4,5-d]pyrimidine-2-carboxamide N-(3-(2-cyano-7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-methyl-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-(hydroxymethyl)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 1-(3-acrylamidophenyl)-7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxo-1,4-dihydropyrimido[4,5-d]pyrimidine-2-carboxamide N-(3-(2-cyano-7-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-methyl-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-(hydroxymethyl)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 1-(3-acrylamidophenyl)-7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxo-1,4-dihydropyrimido[4,5-d]pyrimidine-2-carboxamide N-(3-(2-cyano-7-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(2-methyl-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(2-(hydroxymethyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide 1-(3-acrylamidophenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxo-1,4-dihydropyrimido[4,5-d]pyrimidine-2-carboxamide N-(3-(2-cyano-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4-oxopyrimido[4,5-d]pyrimidin-1(4H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-fluoroethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-ethylpiperazin-1-yl)-2,3-difluorophenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2,3-difluorophenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-fluoroethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-ethylpiperazin-1-yl)-2-fluorophenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-fluorophenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-morpholinophenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-fluoroethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-ethylpiperazin-1-yl)-3-fluorophenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-acetylpiperazin-1-yl)-3-fluorophenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-morpholinophenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-((1-methylpiperidin-4-yl)amino)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-((1-methylpiperidin-4-yl)amino)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-((1-methylpiperidin-4-yl)amino)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-((1-methylpiperidin-4-yl)amino)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide (R)—N-(3-(2-((4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide (S)—N-(3-(2-((4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-fluoroethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-acetylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(5-oxo-2-((4-(piperazin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-chloro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-cyano-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methoxyphenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-chloro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)-3-methoxyphenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-cyano-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)pyridin-3-yl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((5-(4-(2-hydroxyethyl)piperazin-1-yl)pyridin-2-yl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(6-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(4-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(5-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-3-yl)acrylamide N-(2-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-4-yl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)-4-fluorophenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)-2-fluorophenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)-5-fluorophenyl)acrylamide N-(6-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(4-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(5-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-3-yl)acrylamide N-(2-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(2-fluoro-3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-fluoro-5-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(6-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(4-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(5-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-3-yl)acrylamide N-(2-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(2-fluoro-3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-fluoro-5-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(6-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(4-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(5-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-3-yl)acrylamide N-(2-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(2-fluoro-3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-fluoro-5-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(6-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(4-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(5-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-3-yl)acrylamide N-(2-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-4-yl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)-4-fluorophenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)-2-fluorophenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)-5-fluorophenyl)acrylamide N-(6-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(4-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(5-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-3-yl)acrylamide N-(2-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(2-fluoro-3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-fluoro-5-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(6-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(4-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(5-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-3-yl)acrylamide N-(2-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(2-fluoro-3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-fluoro-5-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(6-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(4-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-2-yl)acrylamide N-(5-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-3-yl)acrylamide N-(2-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)pyridin-4-yl)acrylamide N-(4-fluoro-3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(2-fluoro-3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-fluoro-5-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-(hydroxymethyl)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide 8-(3-acrylamidophenyl)-2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxamide N-(3-(7-cyano-2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-(hydroxymethyl)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide 8-(3-acrylamidophenyl)-2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxamide N-(3-(7-cyano-2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-(hydroxymethyl)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide 8-(3-acrylamidophenyl)-2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxamide N-(3-(7-cyano-2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-(hydroxymethyl)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide 8-(3-acrylamidophenyl)-2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxamide N-(3-(7-cyano-2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-(hydroxymethyl)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide 8-(3-acrylamidophenyl)-2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxamide N-(3-(7-cyano-2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-(hydroxymethyl)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide 8-(3-acrylamidophenyl)-2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxamide N-(3-(7-cyano-2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-(hydroxymethyl)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide 8-(3-acrylamidophenyl)-2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxamide N-(3-(7-cyano-2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(7-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(7-(hydroxymethyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide 8-(3-acrylamidophenyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxamide N-(3-(7-cyano-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6-(hydroxymethyl)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6,7-dimethyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide 8-(3-acrylamidophenyl)-2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide N-(3-(6-cyano-2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(6-cyano-2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(7-cyano-2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-6-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-6-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-6-methyl-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(6-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2,3-difluorophenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-fluorophenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-morpholinophenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-acetylpiperazin-1-yl)-3-fluorophenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-morpholinophenyl)amino)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-morpholinophenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-morpholinophenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(7-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-morpholinophenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-morpholinophenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-morpholinophenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-morpholinophenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-morpholinophenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-morpholinophenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((2-fluoro-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-morpholinophenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-morpholinophenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-morpholinophenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-morpholinophenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((3-fluoro-4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-morpholinophenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-methylpiperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-morpholinophenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)-9H-purin-9-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-morpholinophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-morpholinophenyl)amino)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((4-morpholinophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)acrylamide N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)acrylamide N-(3-(6-((4-morpholinophenyl)amino)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)acrylamide N-(3-(6-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((3-fluoro-4-morpholinophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(6-((2-fluoro-4-morpholinophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-morpholinophenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2-fluoro-4-morpholinophenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((3-fluoro-4-morpholinophenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-methylpiperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-morpholinophenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(3-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)phenyl)acrylamide N-(3-(3-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)phenyl)acrylamide N-(3-(3-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)phenyl)acrylamide N-(3-(3-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)phenyl)acrylamide N-(3-(3-((2,3-difluoro-4-morpholinophenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-morpholinophenyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,5-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-morpholinophenyl)amino)imidazo[1,5-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((2,3-difluoro-4-morpholinophenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((2,3-difluoro-4-morpholinophenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(3-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)phenyl)acrylamide N-(3-(3-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)phenyl)acrylamide N-(3-(3-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)phenyl)acrylamide N-(3-(3-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)phenyl)acrylamide N-(3-(3-((2,3-difluoro-4-morpholinophenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)phenyl)acrylamide N-(3-(7-((2,3-difluoro-4-morpholinophenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-morpholinophenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((2,3-difluoro-4-morpholinophenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)phenyl)acrylamide N-(3-(3-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)phenyl)acrylamide N-(3-(3-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)phenyl)acrylamide N-(3-(3-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)phenyl)acrylamide N-(3-(3-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)phenyl)acrylamide N-(3-(3-((4-morpholinophenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-morpholinophenyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,5-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-morpholinophenyl)amino)imidazo[1,5-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(6-((4-morpholinophenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(2-((4-morpholinophenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)phenyl)acrylamide N-(3-(3-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)phenyl)acrylamide N-(3-(3-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)phenyl)acrylamide N-(3-(3-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)phenyl)acrylamide N-(3-(3-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)phenyl)acrylamide N-(3-(3-((4-morpholinophenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)phenyl)acrylamide N-(3-(7-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)phenyl)acrylamide N-(3-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)phenyl)acrylamide N-(3-(7-((4-morpholinophenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-morpholinophenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)phenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-(4-methylpiperazin-1-yl)phenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(3-(5-((4-morpholinophenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpiperidin-4-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpiperidin-4-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpiperidin-4-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpiperidin-4-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(3-(dimethylamino)azetidin-1-yl)-5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(3-(dimethylamino)azetidin-1-yl)-4-methoxyphenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-(3-(dimethylamino)azetidin-1-yl)-4-methoxyphenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(3-(dimethylamino)azetidin-1-yl)-5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylpiperidin-4-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylpiperidin-4-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylpiperidin-4-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylpiperidin-4-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-2-(methyl(1-methylpiperidin-4-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(methyl(1-methylpiperidin-4-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-(methyl(1-methylpiperidin-4-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-2-(methyl(1-methylpiperidin-4-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-2-(4-methylpiperazin-1-yl)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-2-morpholinophenyl)acrylamide N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)phenyl)acrylamide N-(2-(3-(dimethylamino)azetidin-1-yl)-5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(4-methylpiperazin-1-yl)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-morpholinophenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(3-(dimethylamino)azetidin-1-yl)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-(4-methylpiperazin-1-yl)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-morpholinophenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-(3-(dimethylamino)azetidin-1-yl)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-2-(4-methylpiperazin-1-yl)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-2-morpholinophenyl)acrylamide N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)phenyl)acrylamide N-(2-(3-(dimethylamino)azetidin-1-yl)-5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylazetidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-2-((1-methylpiperidin-4-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-((1-methylpiperidin-4-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-((1-methylpiperidin-4-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-2-((1-methylpiperidin-4-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)quinazolin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)quinazolin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)quinazolin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(5-fluoropyridin-3-yl)pyrido[3,2-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(5-fluoropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(5-chloropyridin-3-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)-2-((1-methylazetidin-3-yl)oxy)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[4,5-d]pyrimidin-5-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((9-(3-fluorophenyl)-9H-purin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[4,3-d]pyrimidin-5-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrrolo[1,2-a][1,3,5]triazin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)imidazo[1,5-a][1,3,5]triazin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-[1,2,3]triazolo[1,5-c]pyrimidin-5-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)imidazo[5,1-f][1,2,4]triazin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrrolo[2,3-c]pyridin-5-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[5,4-c]pyridin-5-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-6-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[3,4-c]pyridin-5-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((5-(3-fluorophenyl)pyrrolo[1,2-c]pyrimidin-3-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)imidazo[1,5-c]pyrimidin-7-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)pyrazolo[1,5-c]pyrimidin-5-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((6-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-3-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)imidazo[1,2-a]pyrazin-6-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)imidazo[1,5-a]pyrazin-6-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((7-(3-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)isoxazolo[4,5-d]pyrimidin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((9-(3-fluorophenyl)-9H-purin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((7-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((1-(3-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)isoxazolo[4,3-d]pyrimidin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)pyrrolo[1,2-a][1,3,5]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)imidazo[1,5-a][1,3,5]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)-[1,2,3]triazolo[1,5-c]pyrimidin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((7-(3-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((7-(3-fluorophenyl)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((7-(3-fluorophenyl)imidazo[5,1-f][1,2,4]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)-1H-pyrrolo[2,3-c]pyridin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)isoxazolo[5,4-c]pyridin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((1-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((1-(3-fluorophenyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((1-(3-fluorophenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)isoxazolo[3,4-c]pyridin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((5-(3-fluorophenyl)pyrrolo[1,2-c]pyrimidin-3-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((1-(3-fluorophenyl)imidazo[1,5-c]pyrimidin-7-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)pyrazolo[1,5-c]pyrimidin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((6-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-3-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)imidazo[1,2-a]pyrazin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)imidazo[1,5-a]pyrazin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((7-(3-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[4,5-d]pyrimidin-5-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((9-(3-fluorophenyl)-9H-purin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[4,3-d]pyrimidin-5-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrrolo[1,2-a][1,3,5]triazin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)imidazo[1,5-a][1,3,5]triazin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-[1,2,3]triazolo[1,5-c]pyrimidin-5-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)imidazo[5,1-f][1,2,4]triazin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrrolo[2,3-c]pyridin-5-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[5,4-c]pyridin-5-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-6-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[3,4-c]pyridin-5-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((5-(3-fluorophenyl)pyrrolo[1,2-c]pyrimidin-3-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)imidazo[1,5-c]pyrimidin-7-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)pyrazolo[1,5-c]pyrimidin-5-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((6-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-3-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)imidazo[1,2-a]pyrazin-6-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)imidazo[1,5-a]pyrazin-6-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((7-(3-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)isoxazolo[4,5-d]pyrimidin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((9-(3-fluorophenyl)-9H-purin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((7-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((1-(3-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)isoxazolo[4,3-d]pyrimidin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)pyrrolo[1,2-a][1,3,5]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)imidazo[1,5-a][1,3,5]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)-[1,2,3]triazolo[1,5-c]pyrimidin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((7-(3-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((7-(3-fluorophenyl)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((7-(3-fluorophenyl)imidazo[5,1-f][1,2,4]triazin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)-1H-pyrrolo[2,3-c]pyridin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)isoxazolo[5,4-c]pyridin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((1-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((1-(3-fluorophenyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((1-(3-fluorophenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)isoxazolo[3,4-c]pyridin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((5-(3-fluorophenyl)pyrrolo[1,2-c]pyrimidin-3-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((1-(3-fluorophenyl)imidazo[1,5-c]pyrimidin-7-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)pyrazolo[1,5-c]pyrimidin-5-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((6-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-3-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)imidazo[1,2-a]pyrazin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)imidazo[1,5-a]pyrazin-6-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((7-(3-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[4,5-d]pyrimidin-5-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((9-(3-fluorophenyl)-9H-purin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[4,3-d]pyrimidin-5-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrrolo[1,2-a][1,3,5]triazin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)imidazo[1,5-a][1,3,5]triazin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-[1,2,3]triazolo[1,5-c]pyrimidin-5-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)imidazo[5,1-f][1,2,4]triazin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrrolo[2,3-c]pyridin-5-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[5,4-c]pyridin-5-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-6-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[3,4-c]pyridin-5-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((5-(3-fluorophenyl)pyrrolo[1,2-c]pyrimidin-3-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)imidazo[1,5-c]pyrimidin-7-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)pyrazolo[1,5-c]pyrimidin-5-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((6-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-3-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)imidazo[1,2-a]pyrazin-6-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)imidazo[1,5-a]pyrazin-6-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((7-(3-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)isoxazolo[4,5-d]pyrimidin-5-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((9-(3-fluorophenyl)-9H-purin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((7-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((1-(3-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)isoxazolo[4,3-d]pyrimidin-5-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)pyrrolo[1,2-a][1,3,5]triazin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)imidazo[1,5-a][1,3,5]triazin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)-[1,2,3]triazolo[1,5-c]pyrimidin-5-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((7-(3-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((7-(3-fluorophenyl)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((7-(3-fluorophenyl)imidazo[5,1-f][1,2,4]triazin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)-1H-pyrrolo[2,3-c]pyridin-5-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)isoxazolo[5,4-c]pyridin-5-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((1-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((1-(3-fluorophenyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((1-(3-fluorophenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)isoxazolo[3,4-c]pyridin-5-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((5-(3-fluorophenyl)pyrrolo[1,2-c]pyrimidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((1-(3-fluorophenyl)imidazo[1,5-c]pyrimidin-7-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)pyrazolo[1,5-c]pyrimidin-5-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((6-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)imidazo[1,2-a]pyrazin-6-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((3-(3-fluorophenyl)imidazo[1,5-a]pyrazin-6-yl)amino)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[4,5-d]pyrimidin-5-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((9-(3-fluorophenyl)-9H-purin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[4,3-d]pyrimidin-5-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrrolo[1,2-a][1,3,5]triazin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)imidazo[1,5-a][1,3,5]triazin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-[1,2,3]triazolo[1,5-c]pyrimidin-5-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((7-(3-fluorophenyl)imidazo[5,1-f][1,2,4]triazin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrrolo[2,3-c]pyridin-5-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[5,4-c]pyridin-5-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-6-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)isoxazolo[3,4-c]pyridin-5-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((5-(3-fluorophenyl)pyrrolo[1,2-c]pyrimidin-3-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((1-(3-fluorophenyl)imidazo[1,5-c]pyrimidin-7-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)pyrazolo[1,5-c]pyrimidin-5-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((6-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-3-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)imidazo[1,2-a]pyrazin-6-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((3-(3-fluorophenyl)imidazo[1,5-a]pyrazin-6-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((7-(3-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)isoxazolo[4,5-d]pyrimidin-5-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((9-(3-fluorophenyl)-9H-purin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((7-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((1-(3-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)isoxazolo[4,3-d]pyrimidin-5-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)pyrrolo[1,2-a][1,3,5]triazin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)imidazo[1,5-a][1,3,5]triazin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)-[1,2,3]triazolo[1,5-c]pyrimidin-5-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((7-(3-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((7-(3-fluorophenyl)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((7-(3-fluorophenyl)imidazo[5,1-f][1,2,4]triazin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)-1H-pyrrolo[2,3-c]pyridin-5-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)isoxazolo[5,4-c]pyridin-5-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((1-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((1-(3-fluorophenyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((1-(3-fluorophenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)isoxazolo[3,4-c]pyridin-5-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((5-(3-fluorophenyl)pyrrolo[1,2-c]pyrimidin-3-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((1-(3-fluorophenyl)imidazo[1,5-c]pyrimidin-7-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)pyrazolo[1,5-c]pyrimidin-5-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((6-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-3-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)imidazo[1,2-a]pyrazin-6-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((3-(3-fluorophenyl)imidazo[1,5-a]pyrazin-6-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-6-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-6-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-fluorophenyl)-6-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxy-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-6-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide N-(5-((8-(3-fluorophenyl)-6-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-2-(methyl(1-methylpyrrolidin-3-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-6-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(3-fluorophenyl)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-6-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(5-((8-(3-fluorophenyl)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)-2-((1-methylpyrrolidin-3-yl)oxy)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-6-methyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrimido[4,5-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-7-methyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(2-(2-(dimethylamino)ethoxy)-5-((8-(3-fluorophenyl)-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-2-yl)amino)phenyl)acrylamide N-(5-((8-bromoquinazolin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(5-((8-chloroquinazolin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-methoxyquinazolin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-phenylquinazolin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(pyridin-4-yl)quinazolin-2-yl)amino)phenyl)acrylamide N-(5-((8-(2-chlorophenyl)quinazolin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(2-fluorophenyl)quinazolin-2-yl)amino)phenyl)acrylamide N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((8-(pyridin-3-yl)quinazolin-2-yl)amino)phenyl)acrylamide N-(5-((8-(2-chlorophenyl)quinazolin-2-yl)amino)-2-(2-(dimethylamino)ethoxy)phenyl)acrylamide N-(5-((8-(3-chlorophenyl)quinazolin-2-yl)amino)-2-(2-methoxyethoxy)phenyl)acrylamide N-(5-((3-(3-chlorophenyl)imidazo[1,5-a]pyrazin-6-yl)amino)-2-(2-(dimethylamino)ethoxy)phenyl)acrylamide 1-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(6-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(5-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(5-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(5-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(6-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(6-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a]pyrazin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(6-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,2-a]pyrazin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(3-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(5-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(3-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(5-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)piperidin-1-yl)prop-2-en-1-one 1-(1-acryloylpiperidin-3-yl)-7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrimido[4,5-d]pyrimidin-4(1H)-one 8-(1-acryloylpiperidin-3-yl)-2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-5(8H)-one 8-(1-acryloylpiperidin-3-yl)-2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrido[3,2-d]pyrimidin-6(5H)-one 8-(1-acryloylpiperidin-3-yl)-2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-5-methylpyrido[3,2-d]pyrimidin-6(5H)-one 1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(5-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(5-((4-(4-methylpiperazin-1-yl)phenyl)amino)isoxazolo[4,5-d]pyrimidin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(5-((4-(4-methylpiperazin-1-yl)phenyl)amino)isoxazolo[4,3-d]pyrimidin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,5-a]pyrazin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,2-a]pyrazin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(3-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[1,2-a]pyrazin-6-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[5,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(5-((4-(4-methylpiperazin-1-yl)phenyl)amino)-[1,2,3]triazolo[1,5-c]pyrimidin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(7-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,5-c]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(3-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[1,2-c]pyrimidin-5-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(5-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrazolo[1,5-c]pyrimidin-3-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)imidazo[1,5-a][1,3,5]triazin-8-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrrolo[1,2-a][1,3,5]triazin-8-yl)piperidin-1-yl)prop-2-en-1-one 1-(1-acryloylpiperidin-3-yl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimido[4,5-d]pyrimidin-4(1H)-one 8-(1-acryloylpiperidin-3-yl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-5(8H)-one 8-(1-acryloylpiperidin-3-yl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrido[3,2-d]pyrimidin-6(5H)-one 8-(1-acryloylpiperidin-3-yl)-5-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrido[3,2-d]pyrimidin-6(5H)-one 1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)pyrrolidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)pyrrolidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)pyrrolidin-1-yl)prop-2-en-1-one 1-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)pyrrolidin-1-yl)prop-2-en-1-one 1-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)pyrrolidin-1-yl)prop-2-en-1-one 1-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)pyrrolidin-1-yl)prop-2-en-1-one 1-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)pyrrolidin-1-yl)prop-2-en-1-one 1-(3-(2-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)piperidin-1-yl)prop-2-en-1-one 1-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)pyrrolidin-1-yl)prop-2-en-1-one 1-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-9H-purin-9-yl)piperidin-1-yl)prop-2-en-1-one and 1-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)piperidin-1-yl)prop-2-en-1-one.
108 . A pharmaceutically acceptable salt of the compound according to any one of claims 1 - 107 .
109 . The pharmaceutically acceptable salt of claim 108 , wherein the salt is a chloride, carbonate, gluconate, benzoate, acetate, lactate, citrate, propionate, hydrogenphosphate, fumarate, succinate, or TRIS (hydroxymethyl-aminomethane), maleate, malonate, tartrate, oxalate, pamoate, or stearate salt.
110 . The pharmaceutically acceptable salt of claim 109 , wherein the salt is a chloride, fumarate, malonate, maleate, acetate, lactate, citrate, succinate, or tartrate salt.
111 . The pharmaceutically acceptable salt of claim 110 , wherein the salt is a chloride, fumarate, malonate, maleate, or tartrate salt.
112 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound or pharmaceutically acceptable salt of any one of claims 1 to 111 .
113 . A pharmaceutical composition of claim 112 , wherein the composition is formulated in a form chosen from the group consisting of tablets, capsules, powders, liquids, suspensions, suppositories, and aerosols.
114 . The packaged pharmaceutical composition comprising a pharmaceutical composition of claim 112 or 113 and instructions for using the composition to treat a subject suffering from cancer.
115 . A method of treating cancer in a subject which comprises administering to a subject in need thereof a therapeutically effective amount of the compound or pharmaceutically acceptable salt of any one of claims 1 to 111 .
116 . The method of claim 115 , wherein the cancer is colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, thyroid cancer, fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chondroma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing's tumor, leiomyosarcoma, rhabdomyosarcoma, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, thyroid cancer, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas, cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell lung carcinoma, non-small cell lung cancer, bladder carcinoma, epithelial carcinoma, glioma, astrocytoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendroglioma, meningioma, melanoma, neuroblastoma, retinoblastoma, leukemia, acute lymphocytic leukemia and acute myelocytic leukemia (myeloblastic, promyelocytic, myelomonocytic, monocytic and erythroleukemia); chronic leukemia (chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia); and polycythemia vera, lymphoma (Hodgkin's disease and non-Hodgkin's disease), multiple myeloma, Waldenstrom's macroglobulinemia, or heavy chain disease.
117 . The method of claim 116 , wherein the cancer is non-small cell lung cancer, breast cancer, colon cancer, thyroid cancer, or ovarian cancer.
118 . A method of treating a disorder mediated by EGFR in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound or pharmaceutically acceptable salt of any one of claims 1 to 111 .
119 . A method of treating a disorder in a subject in need thereof, comprising:
a) determining the presence or absence of a EGFR mutation in a biological sample isolated from the subject; and b) if a EGFR mutation or double mutations are determined to be present in the subject, administering to the subject a therapeutically effective amount of the compound or pharmaceutically acceptable salt of any one of claims 1 to 111 .
120 . The method of claim 119 , wherein the EGFR mutation is in codon 790.
121 . The method of claim 119 , wherein the EGFR mutation is del E746-A750, del E747-E749/A750P, del E747-S752/P753S, del E747-T751/Sins/A750P, del S752-I759, G719S, G719C, L861Q, L858R, T790M, or L858R/T790M.
122 . The method of claim 119 , wherein determining the presence or absence of the EGFR mutation comprises amplifying EGFR nucleic acid from the biological sample and sequencing the amplified nucleic acid.
123 . The method of claim 119 , wherein determining the presence or absence of the EGFR mutation comprises detecting a mutant EGFR polypeptide in the biological sample using a binding agent to a mutant EGFR polypeptide.
124 . The method of claim 123 , wherein the binding agent is an antibody.
125 . The method of claim 119 , wherein the biological sample is isolated from a tumor of the subject.
126 . A method of treating a disorder mediated by BTK in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound or pharmaceutically acceptable salt of any one of claims 1 to 111 .
127 . The method of any one of claims 118 - 126 , wherein the disorder is cancer.
128 . The method of claim 127 , wherein the cancer is colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, thyroid cancer, fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chondroma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing's tumor, leiomyosarcoma, rhabdomyosarcoma, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas, cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell lung carcinoma, non-small cell lung cancer, bladder carcinoma, epithelial carcinoma, glioma, astrocytoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendroglioma, meningioma, melanoma, neuroblastoma, retinoblastoma, leukemia, acute lymphocytic leukemia and acute myelocytic leukemia (myeloblastic, promyelocytic, myelomonocytic, monocytic and erythroleukemia); chronic leukemia (chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia); and polycythemia vera, lymphoma (Hodgkin's disease and non-Hodgkin's disease), multiple myeloma, Waldenstrom's macroglobulinemia, or heavy chain disease.
129 . The method of claim 127 , wherein the cancer is non-small cell lung cancer, colon cancer, thyroid cancer, or ovarian cancer.
130 . The method of any one of claims 115 - 129 , further comprising administering an additional anti-cancer and/or cytotoxic agent.
131 . The compound or pharmaceutically acceptable salt of anyone of claims 48 to 57 , wherein E is selected from a group consisting of:Cited by (0)
No later patents cite this yet.
References (0)
No backward citations on record.