Methods of manufacturing an oral composition

Abstract

The disclosure provides for oral compositions comprising a clarified tobacco extract and one or more filler components. In another aspect, the disclosure provides methods of preparing a clarified tobacco extract. Such methods can comprise processing a tobacco extract through at least one ultrafiltration step to provide a filtered tobacco extract and passing the filtered tobacco extract through a solution comprising one or more non-molecularly imprinted polymer (NIP) to provide the clarified tobacco extract.

1 . A method for preparing a clarified tobacco extract, the method comprising:
 processing a tobacco extract through at least one ultrafiltration step to provide a filtered tobacco extract; and   passing the filtered tobacco extract through a solution comprising one or more non-molecularly imprinted polymer (NIP) to provide the clarified tobacco extract.   
     
     
         2 . The method of  claim 1 , further comprising providing the tobacco extract by extracting a tobacco material with an aqueous solution. 
     
     
         3 . The method of  claim 2 , wherein the tobacco material comprises lamina and stems. 
     
     
         4 . The method of  claim 1 , wherein the processing the tobacco extract through at least one ultrafiltration comprises processing through a first ultrafiltration membrane having a nominal molecular weight cut off (NMWCO) of about 50 kda. 
     
     
         5 . The method of  claim 4 , wherein the processing the tobacco extract through at least one ultrafiltration further comprises processing through a second ultrafiltration membrane having a NMWCO of about 5 kda. 
     
     
         6 . The method of  claim 1 , wherein the clarified tobacco extract comprises nicotine in an amount of about 5% to about 50% by weight based on the total weight of the clarified tobacco extract. 
     
     
         7 . The method of  claim 1 , wherein the one or more NIP comprises at least one NIP that is specific for tobacco-specific nitrosamines (TSNAs). 
     
     
         8 . An oral composition comprising: a clarified tobacco extract prepared according to the method of  claim 1 , or a derivative of said clarified tobacco extract; and one or more filler components. 
     
     
         9 . The oral composition of  claim 8 , wherein the clarified tobacco extract comprises nicotine. 
     
     
         10 . The oral composition of  claim 8 , wherein the oral composition is positioned within a pouch. 
     
     
         11 . The oral composition of  claim 8 , wherein the oral composition is in the form of a lozenge. 
     
     
         12 . The oral composition of  claim 8 , wherein the clarified tobacco extract is substantially translucent.