Self-heating biosensor based on lossy mode resonance and, sensing system, methods of using the same

Abstract

A self-heating biosensor based on lossy mode resonance (LMR) includes a waveguide unit and a lossy mode resonance layer. The waveguide unit is a flat plate, including two planes and at least two sets of opposite sides. One set of the opposite sides of the waveguide unit has a light input end and a light output end. The lossy mode resonance layer is disposed on one of the planes of the waveguide unit. Two heating electrodes are formed at two positions of the lossy mode resonance layer, and the two positions are relevant to one set of the opposite sides of the waveguide unit. A biomaterial sensing region having bioprobes are formed between the two heating electrodes. The present disclosure further includes a using method relevant to the self-heating biosensor based on lossy mode resonance.

What is claimed is: 
     
         1 . A self-heating biosensor based on lossy mode resonance comprising:
 a waveguide unit being a flat plate, including two planes and at least two sets of opposite sides, one set of the opposite sides of the waveguide unit having a light input end and a light output end, and   a lossy mode resonance layer disposed on one of the planes of the waveguide unit, two heating electrodes formed at two positions of the lossy mode resonance layer, and the two positions being relevant to one set of the opposite sides of the waveguide unit; a biomaterial sensing region having bioprobes formed between the two heating electrodes,   wherein the biomaterial sensing region is formed by performing a surface modification on the lossy mode resonance layer.   
     
     
         2 . The self-heating biosensor based on lossy mode resonance in  claim 1 , wherein the other plane of the waveguide unit is disposed on a substrate. 
     
     
         3 . The self-heating biosensor based on lossy mode resonance in  claim 1 , wherein the lossy mode resonance layer is composed of a metal oxide or a polymer material. 
     
     
         4 . The self-heating biosensor based on lossy mode resonance in  claim 1 , wherein the waveguide unit is one of a glass substrate, a quartz substrate, a photonic crystal substrate, and a polymer material substrate. 
     
     
         5 . The self-heating biosensor based on lossy mode resonance in  claim 1 , wherein the bioprobes are composed of a boride functional group or a DNA probe. 
     
     
         6 . A self-heating biosensing system based on lossy mode resonance, comprising:
 a broadband light source,   an input optical fiber coupled to the broadband light source,   a sensing module coupled to the input optical fiber, and the sensing module including:   a waveguide unit being a flat plate, including two planes and at least two sets of opposite sides, one set of the opposite sides of the waveguide unit having a light input end and a light output end, and   a lossy mode resonance layer disposed on one of the planes of the waveguide unit, two heating electrodes formed at two positions of the lossy mode resonance layer, and the two positions being relevant to one set of the opposite sides of the waveguide unit; a biomaterial sensing region having bioprobes formed between the two heating electrodes,   an output optical fiber coupled to the light output end, and   a spectrometer coupled to the output optical fiber,   wherein an incident light emitted by the broadband light source is configured to lossy mode resonance in the sensing module; and the biomaterial sensing region is formed by performing a surface modification on the lossy mode resonance layer.   
     
     
         7 . The self-heating biosensing system based on lossy mode resonance in  claim 6 , further including a fiber optic attenuator and an analysis host coupled to the fiber optic attenuator, wherein an optical fiber attenuator is coupled to the input optical fiber, and the analysis host is coupled to the spectrometer. 
     
     
         8 . The self-heating biosensing system based on lossy mode resonance in  claim 6 , wherein the bioprobes are composed of a boride functional group or a DNA probe. 
     
     
         9 . A method of using a self-heating biosensor based on lossy mode resonance, comprising the steps of:
 placing an object to be tested on a biological material sensing region with bioprobes of a lossy mode resonance layer,   inputting an incident light from a broadband light source to a waveguide unit disposed under the lossy mode resonance layer,   measuring a light outputted from the waveguide unit by a spectrometer, and   heating the biomaterial sensing region by energizing the lossy mode resonance layer.   
     
     
         10 . The method of using the self-heating biosensor based on lossy mode resonance in  claim 9 , wherein the bioprobes are composed of a boride functional group or a DNA probe.