Platform and system for digital personalized medicine

Abstract

The digital personalized medicine system uses digital data to assess or diagnose symptoms of a subject to provide personalized or more appropriate therapeutic interventions and improved diagnoses. The use of prioritized questions and answers with associated feature importance can be used to assess mental function and allow a subject to be diagnosed with fewer questions, such that diagnosis can be repeated more often and allow the dosage to be adjusted more frequently. Pharmacokinetics of the subject can be estimated based on demographic data and biomarkers or measured, in order to determine a treatment plan for the subject. Also, biomarkers can be used to determine when the patient may be at risk for experiencing undesirable side effects and the treatment plan adjusted accordingly.

What is claimed is: 
     
         1 . A computer-implemented method for determining an updated amount or an updated timing of a digital therapeutic for treating a human subject suffering from a substance abuse disorder, said method comprising:
 (a) providing, by a smart device, an amount or timing of said digital therapeutic to said human subject to address said substance abuse disorder;   (b) receiving, by said smart device, subject data for said human subject, wherein said subject data comprises information for said substance abuse disorder, demographic data of said human subject, metabolic data of said human subject, pharmacokinetic data of said human subject, interaction data of said human subject, clearance data of said human subject, or microbiome data of said human subject;   (c) determining, by said smart device, said updated amount or said updated timing of said digital therapeutic for alleviating symptoms associated with said substance abuse disorder using a therapeutic module, wherein said therapeutic module uses said subject data and said amount or said timing to generate said updated amount or said updated timing of said digital therapeutic; and   (d) treating, by said smart device, said human subject with said digital therapeutic according to said updated amount or said updated timing for alleviating symptoms associated with said substance abuse disorder that is determined in (c).   
     
     
         2 . The method of  claim 1 , further comprising requesting, by a graphical user interface of said smart device, at least a portion of said subject data. 
     
     
         3 . The method of  claim 1 , further comprising providing a graphical user interface configured to receive questions for a medical professional and submit said questions to said medical professional. 
     
     
         4 . The method of  claim 1 , wherein said human subject is being treated with a drug therapy. 
     
     
         5 . The method of  claim 4 , wherein said digital therapeutic comprises a behavioral therapy that is used in combination with said drug therapy. 
     
     
         6 . The method of  claim 1 , wherein said method is implemented as a mobile app that provides said digital therapeutic. 
     
     
         7 . The method of  claim 6 , wherein said digital therapeutic comprises one or more tests, suggested behavior, activity, game, or interactive session. 
     
     
         8 . The method of  claim 7  further comprising providing, by said smart device, a recommendation for said one or more tests, suggested behavior, activity, game, or interactive session to address said substance abuse disorder. 
     
     
         9 . The method of  claim 7 , wherein at least a portion of said subject data is recorded by said smart device as interaction or feedback between said human subject and said digital therapeutic. 
     
     
         10 . The method of  claim 9 , wherein said interaction or feedback recorded by said smart device comprises meta-data from said human subject including interaction with said mobile app that captures aspects of said human subject's behaviors, profile, activities, interactions with games or activities, frequency of use, session time, options or features selected, or content and activity preferences. 
     
     
         11 . The method of  claim 9 , wherein said smart device is a smart phone or a tablet. 
     
     
         12 . A computer-implemented method for providing a digital therapeutic as part of a personalized treatment plan for treating a human subject suffering from a substance abuse disorder, said method comprising:
 (a) providing, by a smart device, said digital therapeutic to said human subject to address said substance abuse disorder, wherein said digital therapeutic comprises instructions, feedback, activities, or games, wherein said human subject is being treated with a therapeutic agent;   (b) receiving, by said smart device, subject data for said human subject, wherein said subject data comprises information for said substance abuse disorder, demographic data of said human subject, metabolic data of said human subject, pharmacokinetic data of said human subject, interaction data of said human subject, clearance data of said human subject, or microbiome data of said human subject, wherein at least some of said subject data is obtained from interactions between said human subject and said digital therapeutic, wherein said subject data comprises video, audio, or responses to questions or activities, wherein said subject data comprises an active or passive data stream of said interactions;   (c) adjusting, by said smart device, said digital therapeutic using a therapeutic module, wherein said therapeutic module adjusts said digital therapeutic based on said subject data for said human subject;   (d) providing, by said smart device, said human subject with said digital therapeutic to alleviate symptoms associated with said substance abuse disorder; and   (e) monitoring, by said smart device, performance or progress of said human subject to track compliance with said personalized treatment plan.   
     
     
         13 . The method of  claim 12 , wherein said smart device is a smart phone or a tablet. 
     
     
         14 . The method of  claim 12 , further comprising providing, by said smart device, a graphical user interface configured to allow a user to submit said subject data to a medical professional. 
     
     
         15 . The method of  claim 12 , further comprising providing, by said smart device, a graphical user interface configured to request at least a portion of said subject data. 
     
     
         16 . The method of  claim 12 , wherein said digital therapeutic comprises a behavioral therapy that is used in combination with said therapeutic agent. 
     
     
         17 . The method of  claim 12 , wherein said method is implemented using a mobile app installed on said smart device that provides said digital therapeutic. 
     
     
         18 . The method of  claim 17 , wherein said digital therapeutic comprises one or more tests, suggested behavior, activity, game, or interactive session. 
     
     
         19 . The method of  claim 18 , wherein at least a portion of said subject data is recorded by said smart device as interaction or feedback between said human subject and said digital therapeutic. 
     
     
         20 . The method of  claim 19 , wherein said interaction or feedback recorded by said smart device comprises meta-data from said human subject including interaction with said mobile app that captures aspects of said human subject's behaviors, profile, activities, interactions with games or activities, frequency of use, session time, options or features selected, or content and activity preferences.