Systems for perivascular nerve denervation

Abstract

Provided is a catheter including a shaft having a distal end and a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy for nerve denervation at least a portion of the tissue. The loop includes a body capable of bending to curl around the tissue an electrode disposed on the body and a substrate embedded in the body and separated from the electrode. The nerve denervation is performed at a loop temperature of 48° C. to 65° C. for 70 to 150 seconds.

What is claimed is: 
     
         1 . A catheter apparatus for perivascular nerve denervation, comprising:
 a shaft having a distal end; and   a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy for nerve denervation at least a portion of the tissue,   wherein the loop includes: a body capable of bending to curl around the tissue; an electrode disposed on the body; and a substrate embedded in the body and separated from the electrode, and   the nerve denervation is performed at a loop temperature of 48° C. to 65° C. for 70 to 150 seconds.   
     
     
         2 . The catheter apparatus of  claim 1 , wherein the nerve denervation is performed at the loop temperature of 48° C. to 50° C. for 120 to 150 seconds. 
     
     
         3 . The catheter apparatus of  claim 1 , wherein the nerve denervation is performed at the loop temperature of 60° C. to 65° C. for 70 to 120 seconds. 
     
     
         4 . The catheter apparatus of  claim 3 , wherein the tissue is an artery including a lumen, a tunica media and a tunica adventitia. 
     
     
         5 . The catheter apparatus of  claim 4 , wherein a thermal lesion boundary between the tunica media and the tunica adventitia is 1.3 mm to 1.5 mm. 
     
     
         6 . The catheter apparatus of  claim 5 , wherein the lumen has a diameter of 2 mm, a tunica media has a thickness of 0.5 mm and a tunica adventitia has a thickness of 1 mm. 
     
     
         7 . The catheter apparatus of  claim 4 , wherein a thermal lesion boundary between the tunica media and the tunica adventitia is 1.1 mm to 1.3 mm. 
     
     
         8 . The catheter apparatus of  claim 7 , wherein the lumen has a diameter of 1.4 mm, a tunica media has a thickness of 0.6 mm and a tunica adventitia has a thickness of 1.2 mm. 
     
     
         9 . A catheter apparatus for perivascular nerve denervation, comprising:
 a shaft having a distal end; and   a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue,   wherein the loop includes: a first film capable of bending to curl around the tissue; a plurality of electrodes disposed on the first film and arranged in parallel to each other with a predetermined distance; and a sensor disposed at a position corresponding to a position between the plurality of electrodes, and   the nerve denervation is performed at a loop temperature of 48° C. to 65° C. for 70 to 150 seconds.   
     
     
         10 . The catheter apparatus of  claim 9 , wherein the nerve denervation is performed at the loop temperature of 48° C. to 50° C. for 120 to 150 seconds. 
     
     
         11 . The catheter apparatus of  claim 9 , wherein the nerve denervation is performed at the loop temperature of 60° C. to 65° C. for 70 to 120 seconds. 
     
     
         12 . The catheter apparatus of  claim 11 , wherein the tissue is an artery including a lumen, a tunica media and a tunica adventitia. 
     
     
         13 . The catheter apparatus of  claim 12 , wherein a thermal lesion boundary between the tunica media and the tunica adventitia is 1.3 mm to 1.5 mm. 
     
     
         14 . The catheter apparatus of  claim 13 , wherein the lumen has a diameter of 2 mm, a tunica media has a thickness of 0.5 mm and a tunica adventitia has a thickness of 1 mm. 
     
     
         15 . The catheter apparatus of  claim 12 , wherein a thermal lesion boundary between the tunica media and the tunica adventitia is 1.1 mm to 1.3 mm. 
     
     
         16 . The catheter apparatus of  claim 15 , wherein the lumen has a diameter of 1.4 mm, a tunica media has a thickness of 0.6 mm and a tunica adventitia has a thickness of 1.2 mm. 
     
     
         17 . A method for perivascular nerve denervation using a catheter having a loop, comprising:
 positioning the loop near a tissue, the loop including an electrode and a substrate;   delivering energy to at least one of the electrode and the substrate, thereby to cause the loop to curl around the tissue;   causing the at least one of the electrode and the substrate to convert the energy into heat energy; and   denervating at least a portion of the tissue using the heat energy at a loop temperature of 48° C. to 65° C. for 70 to 150 seconds.   
     
     
         18 . The method of  claim 17 , wherein the denervating includes denervating at least a portion of the tissue using the heat energy at a loop temperature of 48° C. to 50° C. for 120 to 150 seconds.