Method for the treatment of fatty liver disease

Abstract

The invention provides a method of treating, inhibiting and/or preventing fatty liver disease in a patient in need thereof, comprising administering an effective amount of a cyclohexenone compound of the following formula (I) to said patient,

1 . A method of treating, inhibiting and/or preventing non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) caused by non-chemical injury in a patient, comprising (a) selecting a patient having NAFLD or NASH caused by non-chemical injury, and (b) administering to said patient an effective amount of a compound 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt, or solvate thereof. 
     
     
         2 . The method of  claim 1 , wherein said compound decreases blood glucose and/or triglyceride level. 
     
     
         3 . The method of  claim 2 , wherein said compound decreases blood glucose level but not both ALT and AST level in a fatty liver condition of a patient. 
     
     
         4 . The method of  claim 1 , wherein said compound decreases fibrosis and/or cirrhosis of steatohepatitis liver cells. 
     
     
         5 . The method of  claim 1 , wherein the compound is isolated from the organic solvent extracts of  Antrodia camphorata,  or prepared synthetically or semi-synthetically. 
     
     
         6 . The method of  claim 1 , wherein the compound, or a pharmaceutically acceptable salt or solvate thereof, is administered orally, parenterally or intravenously. 
     
     
         7 . The method of  claim 1 , wherein the compound, or a pharmaceutically acceptable salt or solvate thereof, is administered orally. 
     
     
         8 . The method of  claim 1 , wherein the compound is administered with a second ingredient suitable for treating NAFLD or NASH.