US2021187163A1PendingUtilityA1

Cardiovascular Prostheses

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Assignee: CORMATRIX CARDIOVASCULAR INCPriority: Dec 16, 2011Filed: Feb 17, 2021Published: Jun 24, 2021
Est. expiryDec 16, 2031(~5.4 yrs left)· nominal 20-yr term from priority
Inventors:Robert G. Matheny
A61L 27/3834A61F 2210/0004A61F 2250/0067A61L 27/3633A61L 2300/414A61K 31/4418A61L 27/507A61L 27/34A61L 2430/20A61L 27/54A61F 2/0095A61L 27/58A61F 2/06A61F 2/00
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Claims

Abstract

Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that include particulate structures that are formed from an ECM/ECM-mimicking composition. The ECM/ECM-mimicking composition consists of a mixture of particulate structures including particulate structures formed from acellular ECM derived from a mammalian tissue source and particulate structures formed from poly(glycerol sebacate) (PGS) and everolimus.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A cardiovascular prosthesis, consisting of:
 an ECM/ECM-mimicking composition consisting of a first plurality of first particulate structures and a second plurality of second particulate structures,   said first plurality of first particulate structures consisting of acellular extracellular matrix (ECM) from a mammalian tissue source,   said second plurality of second particulate structures consisting of poly(glycerol sebacate) (PGS) and everolimus,   said first plurality of first particulate structures and said second plurality of second particulate structures, when disposed proximate damaged cardiovascular tissue, adapted to jointly induce remodeling of said damaged cardiovascular tissue,   said second plurality of second particulate structures, when disposed proximate said damaged cardiovascular tissue, further adapted to suppress hyperplasia.

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