Mixing channel for an inhalation device and inhalation device

Abstract

The invention relates to a mixing channel for an inhalation device, and in particular to a mixing channel with improved injection and mixing properties for injecting and mixing a liquid drug into an air flow streaming in the mixing channel, thereby producing an aerosol to be inhaled by a patient. One aspect of the invention relates to a mixing channel for an inhalation device, comprising an inlet opening, an outlet opening, and an injection zone located between the inlet opening and the outlet opening, wherein the injection zone has a longitudinal center axis, wherein the injection zone comprises (a) a built-in nebulizer, or (b) a detachable nebulizer, or (c) a member adapted to receive a detachable nebulizer, wherein the effective cross sectional area of the mixing channel in a plane perpendicular to the longitudinal center axis is smaller in the injection zone than upstream of the injection zone.

1 - 15 . (canceled) 
     
     
         16 . An inhalation device comprising:
 a mixing channel having a longitudinal center axis, the mixing channel comprising:
 a first channel portion, comprising:
 an upstream end comprising an inlet opening, and 
 a downstream end comprising a transition opening, 
 
 a second channel portion, comprising:
 an upstream end comprising the transition opening, and 
 a downstream end comprising an outlet opening, 
 
 wherein the downstream end of the first channel portion comprises a wall that is orthogonal to the longitudinal center axis of the mixing channel, so that a step is formed between the first channel portion and the second channel portion; and 
   a vibrating mesh nebulizer comprising a perforated membrane,   wherein the vibrating mesh nebulizer protrudes into the first channel portion adjacent to the wall from a side of the mixing channel so that the perforated membrane is flush with the upstream end of the second channel portion on the side adjacent to the vibrating mesh nebulizer.   
     
     
         17 . The inhalation device of  claim 16 , wherein the wall obstructs about 50% of a cross-sectional area of the first channel portion. 
     
     
         18 . The inhalation device of  claim 16 , wherein the vibrating mesh nebulizer obstructs about 50% of a cross-sectional area of the first channel portion. 
     
     
         19 . The inhalation device of  claim 16 , wherein there is a step-free transition between the first channel portion and the second channel portion on a side opposite the vibrating mesh nebulizer. 
     
     
         20 . The inhalation device of  claim 16 , wherein the vibrating mesh nebulizer is positioned to emit an aerosol at, or near and towards the longitudinal center axis of the mixing channel at an angle of 90° or an angle from 45° to 135° with respect to the longitudinal center axis of the mixing channel. 
     
     
         21 . The inhalation device of  claim 16 , wherein the vibrating mesh nebulizer further comprises:
 a main member that is connectable with a liquid drug reservoir; and   a ring member made of piezoelectric material,   wherein the main member comprises a tubular portion comprising an outer area exhibiting a ring-shaped widening onto which the ring member is attached such that the main member extends through the ring member.   
     
     
         22 . The inhalation device of  claim 16 , wherein an opening angle of the second channel portion immediately downstream of the step is constant. 
     
     
         23 . The inhalation device of  claim 16 , wherein the opening angle of the second channel portion immediately downstream of the step is not more than 8°. 
     
     
         24 . The inhalation device of  claim 16 , wherein the inlet opening of the mixing channel is connectable with an inlet channel of the inhalation device. 
     
     
         25 . The inhalation device of  claim 16 , wherein the vibrating mesh nebulizer protrudes into the first channel portion adjacent to the wall from the side of the mixing channel so that a cross-sectional area of the second channel portion immediately downstream of the nebulizer is smaller than a cross-sectional area of the first channel portion immediately upstream of the nebulizer. 
     
     
         26 . An inhalation device comprising:
 a mixing channel having a longitudinal center axis, the mixing channel comprising:
 a first channel portion, comprising:
 an upstream end comprising an inlet opening, and 
 a downstream end comprising a transition opening, 
 
 a second channel portion, comprising:
 an upstream end comprising the transition opening, and 
 a downstream end comprising an outlet opening, 
 
 wherein the downstream end of the first channel portion comprises a wall that is orthogonal to the longitudinal center axis of the mixing channel, so that a step is formed between the first channel portion and the second channel portion; and 
   a vibrating mesh nebulizer comprising a perforated membrane,   wherein the vibrating mesh nebulizer protrudes into the first channel portion adjacent to the wall from the side of the mixing channel so that a cross-sectional area of the second channel portion immediately downstream of the nebulizer is smaller than a cross-sectional area of the first channel portion immediately upstream of the nebulizer.   
     
     
         27 . The inhalation device of  claim 26 , wherein the wall obstructs about 50% of the cross-sectional area of the first channel portion. 
     
     
         28 . The inhalation device of  claim 26 , wherein the vibrating mesh nebulizer obstructs about 50% of the cross-sectional area of the first channel portion. 
     
     
         29 . The inhalation device of  claim 26 , wherein there is a step-free transition between the first channel portion and the second channel portion on a side opposite the vibrating mesh nebulizer. 
     
     
         30 . The inhalation device of  claim 26 , wherein the vibrating mesh nebulizer is positioned to emit an aerosol at, or near and towards the longitudinal center axis of the mixing channel at an angle of 90° or an angle from 45° to 135° with respect to the longitudinal center axis of the mixing channel. 
     
     
         31 . The inhalation device of  claim 26 , wherein the vibrating mesh nebulizer further comprises:
 a main member that is connectable with a liquid drug reservoir; and   a ring member made of piezoelectric material,   wherein the main member comprises a tubular portion comprising an outer area exhibiting a ring-shaped widening onto which the ring member is attached such that the main member extends through the ring member.   
     
     
         32 . The inhalation device of  claim 26 , wherein an opening angle of the second channel portion immediately downstream of the step is constant. 
     
     
         33 . The inhalation device of  claim 26 , wherein the opening angle of the second channel portion immediately downstream of the step is not more than 8°. 
     
     
         34 . The inhalation device of  claim 26 , wherein the inlet opening of the mixing channel is connectable with an inlet channel of the inhalation device.