Compositions for Treatment or Prevention of Infectious Inflammatory Diseases, or Compositions for Immune Enhancement, Comprising, Tryptophanyl-tRNA Synthetase as an Active Ingredient

Abstract

The present invention relates to a composition for treatment or prevention of infectious inflammatory diseases comprising tryptophanyl-tRNA synthetase as an active ingredient, and a composition for immune enhancement. More specifically, the present invention relates to a pharmaceutical composition for treatment or prevention of infectious inflammatory diseases comprising tryptophanyl-tRNA synthetase as an active ingredient, a food composition for preventing or improving, a veterinary composition for preventing or treating, and a composition for immune enhancement comprising a tryptophanyl-tRNA synthetase as an active ingredient, respectively. The composition of the present invention can be effectively used for preventing or treating diseases of humans and animals caused by infection from bacteria, viruses or fungi and the like by inhibiting infections such as bacterial, viral, and fungal infections at an early stage particularly through activating innate immune response.

1 .- 12 . (canceled) 
     
     
         13 . A composition for preventing or treating an infectious inflammatory disease in a subject caused by a virus, a bacterium, or fungus comprising tryptophanyl-tRNA synthetase as an active ingredient, wherein the tryptophanyl-tRNA synthetase is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, and SEQ ID NO:8 and wherein the tryptophanyl-tRNA synthetase induces neutrophil accumulation in the body of the subject. 
     
     
         14 . The composition of  claim 13 , wherein the composition is a pharmaceutical composition or a veterinary composition. 
     
     
         15 . The composition of  claim 13 , wherein the composition is a food composition. 
     
     
         16 . The composition of  claim 13 , wherein the infectious inflammatory disease is selected from the group consisting of  salmonellosis , food poisoning, typhoid, paratyphoid, sepsis, septic shock, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), pneumonia, pulmonary tuberculosis, tuberculosis, cold, influenza, airway infection, rhinitis, nasopharyngitis, otitis media, bronchitis, lymphadenitis, mumps, adenolymphitis, cheilitis, stomatitis, arthritis, myositis, dermatitis, vasculitis, gingivitis, pericementitis, keratitis, conjunctivitis, wound infection, peritonitis, hepatitis, osteomyelitis, cellulitis, meningitis, encephalitis, brain abscess, encephalomyelitis, cerebral meningitis, osteomyelitis, nephritis, carditis, endocarditis, enteritis, gastritis, esophagitis, duodenitis, colitis, urinary tract infection, cystitis, vaginitis, cervicitis, salpingitis, infectious erythema, bacterial dysentery, abscess and ulcer, bacteremia, diarrhea, dysentery, gastritis, gastroenteritis, genitourinary abscess, open wound or wound infection, purulent inflammation, abscesses, boils, pyoderma, impetigo, folliculitis, cellulitis, wound infection after surgery, scalded skin syndrome, skin burn syndrome, thrombotic thrombocytopenia, hemolytic uremic syndrome, renal failure, pyelonephritis, glomerulonephritis, nervous system abscess, otitis media, sinusitis, pharyngitis, tonsillitis, mastoiditis, soft tissue inflammation, dental infection, dacryocystitis, pleurisy, abdominal abscess, liver abscess, cholecystitis, spleen abscess, pericarditis, myocarditis, placentitis, amniotic fluid infection, mammitis, mastitis, puerperal fever, toxic shock syndrome, lyme disease, gas gangrene, atherosclerosis,  Mycobacterium avium  syndrome (MAC), enterohaemorrhagic  Escherichia coli  (EHEC) infection, enteropathogenic  Escherichia coli  (EPEC) infection, enteroinvasive  Escherichia coli  (EIEC) infection, methicillin-resistant  Staphylococcus aureus  (MRSA) infections, vancomycin-resistant  Staphylococcus aureus  (VRSA) infections and listerosis. 
     
     
         17 . A composition for immune enhancement comprising tryptophanyl tRNA synthetase as an active ingredient, wherein the tryptophanyl-tRNA synthetase is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, and SEQ ID NO:8.