Methods of administering anionic cannabinoids dissolved in water

Abstract

Various aspects of this patent document relate to methods to administer compositions comprising anionic cannabinoids.

What is claimed is: 
     
         1 . A method to change the color of a composition, comprising:
 providing a composition comprising 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate, wherein the composition has a color; and   contacting the composition with a Brønsted acid, wherein contacting the composition with the Brønsted acid changes the color to either a different color or colorless.   
     
     
         2 . The method of  claim 1 , wherein the color is purple. 
     
     
         3 . The method of  claim 1 , wherein the composition comprises water; and the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate is dissolved in the water. 
     
     
         4 . The method of  claim 1 , comprising administering the composition to a subject, wherein the subject is a human being, and the administering is oral, self-administration performed by the subject by drinking the composition. 
     
     
         5 . The method of  claim 1 , wherein:
 providing the composition comprises providing a container that contains 25 milliliters to 800 milliliters of the composition; and   the composition comprises 50 micrograms to 500 milligrams of the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate.   
     
     
         6 . The method of  claim 5 , wherein:
 the composition has an actual color;   the container is physically associated with a label;   the label comprises an image of a reference color; and   the method comprises comparing the actual color to the reference color to either confirm the identity of the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate or confirm the approximate concentration of the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate in the composition.   
     
     
         7 . The method of  claim 1 , wherein:
 the color is purple;   the composition comprises water;   the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate is dissolved in the water;   the composition has a pH of 8.5 to 10.5;   providing the composition comprises providing a hermetically-sealed container that contains 25 milliliters to 800 milliliters of the composition and unsealing the hermetically-sealed container;   the composition comprises 50 micrograms to 500 milligrams of the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate;   the method comprises administering the composition to a subject;   the subject is a human being; and   the administering is oral, self-administration performed by the subject by drinking the composition.   
     
     
         8 . A method to change the color of a composition, comprising:
 providing a composition comprising 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-3-hydroxy-5-pentylphenolate, wherein the composition has a color; and   contacting the composition with a Brønsted acid, wherein contacting the composition with the Brønsted acid changes the color to either a different color or colorless.   
     
     
         9 . The method of  claim 8 , wherein the color is purple. 
     
     
         10 . The method of  claim 8 , wherein the composition comprises water; and the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-3-hydroxy-5-pentylphenolate is dissolved in the water. 
     
     
         11 . The method of  claim 8 , comprising administering the composition to a subject, wherein the subject is a human being, and the administering is oral, self-administration performed by the subject by drinking the composition. 
     
     
         12 . The method of  claim 8 , wherein:
 providing the composition comprises providing a container that contains 25 milliliters to 800 milliliters of the composition; and   the composition comprises 50 micrograms to 500 milligrams of the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-3-hydroxy-5-pentylphenolate.   
     
     
         13 . The method of  claim 12 , wherein:
 the composition has an actual color;   the container is physically associated with a label;   the label comprises an image of a reference color; and   the method comprises comparing the actual color to the reference color to either confirm the identity of the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-3-hydroxy-5-pentylphenolate or confirm the approximate concentration of the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-3-hydroxy-5-pentylphenolate in the composition.   
     
     
         14 . The method of  claim 8 , wherein:
 the color is purple;   the composition comprises water;   the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-3-hydroxy-5-pentylphenolate is dissolved in the water;   the composition has a pH of 8.5 to 10.5;   providing the composition comprises providing a hermetically-sealed container that contains 25 milliliters to 800 milliliters of the composition and unsealing the container;   the composition comprises 50 micrograms to 500 milligrams of the 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-3-hydroxy-5-pentylphenolate;   the method comprises administering the composition to a subject;   the subject is a human being; and   the administering is oral, self-administration performed by the subject by drinking the composition.   
     
     
         15 . A method to change the color of a composition, comprising:
 providing a composition comprising (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-oxide, wherein the composition has a color; and   contacting the composition with a Brønsted acid, wherein contacting the composition with the Brønsted acid changes the color to either a different color or colorless.   
     
     
         16 . The method of  claim 15 , wherein the color is purple. 
     
     
         17 . The method of  claim 15 , wherein the composition comprises water; and the (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-oxide is dissolved in the water. 
     
     
         18 . The method of  claim 15 , comprising administering the composition to a subject, wherein the subject is a human being, and the administering is oral, self-administration performed by the subject by drinking the composition. 
     
     
         19 . The method of  claim 15 , wherein:
 providing the composition comprises providing a container that contains 25 milliliters to 800 milliliters of the composition; and   the composition comprises 50 micrograms to 500 milligrams of the (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-oxide.   
     
     
         20 . The method of  claim 15 , wherein:
 the color is purple;   the composition comprises water;   the (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-oxide is dissolved in the water;   the composition has a pH of 8.5 to 10.5;   providing the composition comprises providing a hermetically-sealed container that contains 25 milliliters to 800 milliliters of the composition and unsealing the container;   the composition comprises 50 micrograms to 500 milligrams of the (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-oxide;   the method comprises administering the composition to a subject;   the subject is a human being; and   the administering is oral, self-administration performed by the subject by drinking the composition.