Expandable implantable conduit

Abstract

Implantable devices including conduits that have markings along the length of the conduit are described herein.

1 . A device comprising:
 a plastically deformable conduit comprising a continuous sheet of a biocompatible polymer, the plastically deformable conduit having an outer surface having a length; and   an additional component;   wherein the plastically deformable conduit has a plurality of dashed radiopaque circumferential markings spaced along the length of the outer surface;   wherein the plastically deformable conduit has a plurality of dashed radiopaque longitudinal markings spaced along the length of the outer surface; and   wherein the plastically deformable conduit is configured to be expanded from a pre-expansion state having a pre-expansion inner diameter to a post-expansion state having a post-expansion inner diameter.   
     
     
         2 . The implantable device of  claim 1 , wherein the additional component is disposed within the plastically deformable conduit. 
     
     
         3 . The implantable device of  claim 1 , wherein the additional component is disposed over the outer surface of the plastically deformable conduit. 
     
     
         4 . The implantable device of  claim 1 , wherein the additional component comprises one or more anticoagulants. 
     
     
         5 . The implantable device of  claim 4 , wherein the one or more anticoagulants are selected from the group consisting of coumadin, heparin, a heparin derivative, a Factor Xa inhibitor, a direct thrombin inhibitor, hementin, sintered porous titanium microspheres, and a combination thereof. 
     
     
         6 . The implantable device of  claim 1 , wherein the additional component comprises a stent. 
     
     
         7 . The implantable device of  claim 1 , further comprising one or more letters on the outer surface of the plastically deformable conduit, one or more numbers on the outer surface of the plastically deformable conduit, or a combination thereof. 
     
     
         8 . The implantable device of  claim 7 , wherein the one or more letters and the one or more numbers are individually radiopaque. 
     
     
         9 . The implantable device of  claim 7 , wherein the one or more letters and the one or more numbers are visible. 
     
     
         10 . The implantable device of  claim 1 , wherein at least one of the plurality of circumferential markings and the plurality of longitudinal markings display conduit length, conduit orientation, conduit diameter, or a combination thereof. 
     
     
         11 . The implantable device of  claim 1 , wherein the biocompatible polymer comprises a fluoropolymer. 
     
     
         12 . The implantable device of  claim 1 , wherein the plastically deformable conduit has a yield strength of about 0.1 MPa to about 4 MPa. 
     
     
         13 . The implantable device of  claim 1 , wherein the plastically deformable conduit further comprises a valve. 
     
     
         14 . A method comprising:
 printing a plurality of dashed radiopaque circumferential markings spaced along a circumference and a length of a conduit by pad-printing with a cliché; and   printing a plurality of dashed radiopaque longitudinal markings spaced along the length of the conduit by a pad-printing with a cliché;   wherein the plurality of dashed radiopaque circumferential markings spaced along the length of the conduit are separated by a distance greater than a diameter of the conduit;   wherein the conduit comprises a continuous sheet of a biocompatible polymer;   wherein the conduit is configured to be expanded from a pre-expansion state having a pre-expansion inner diameter to a post-expansion state having a post-expansion inner diameter; and   wherein an additional component is disposed within the conduit.   
     
     
         15 . A method of monitoring an implantable device, the method comprising:
 implanting the implantable device comprising:
 a plastically deformable conduit comprising a continuous sheet of a biocompatible polymer, the plastically deformable conduit having an outer surface having a length; and 
 an additional component; 
 wherein the plastically deformable conduit has a plurality of dashed radiopaque circumferential markings spaced along the length of the outer surface; 
 wherein the plastically deformable conduit has a plurality of dashed radiopaque longitudinal markings spaced along the length of the outer surface; and 
 wherein the plastically deformable conduit is configured to be expanded from a pre-expansion state having a pre-expansion inner diameter to a post-expansion state having a post-expansion inner diameter; and 
   expanding the plastically deformable conduit from the pre-expansion state to the post-expansion state; and   visualizing at least one of: the plurality of dashed radiopaque circumferential markings and the plurality of dashed radiopaque longitudinal markings;   thereby monitoring a parameter of the conduit in the pre-expansion state and the post-expansion state;   wherein the parameter is selected from the group consisting of a position, a circumference, a length, and a combination thereof.