Intravenous baclofen formulations and treatment methods

Abstract

An intravenous baclofen solution is disclosed, along with methods of dosing and treatment therewith.

1 .- 26 . (canceled) 
     
     
         27 . A method of formulating a pharmaceutical solution for intravenous administration to a human subject presently being treated with a therapeutically effective amount of oral baclofen, the method comprising:
 determining a therapeutically effective amount of intravenous baclofen by multiplying the therapeutically effective amount of oral baclofen by between about 0.7 and about 0.8; and   dissolving the therapeutically effective dose of intravenous baclofen in at least one of normal saline, dextrose solution, Lactated Ringer's solution, or any combination thereof.   
     
     
         28 . The method of  claim 27 , wherein determining the therapeutically effective amount of intravenous baclofen comprises multiplying the therapeutically effective amount of oral baclofen by about 0.74. 
     
     
         29 . The method of  claim 27 , wherein determining the therapeutically effective amount of intravenous baclofen comprises multiplying the therapeutically effective amount of oral baclofen by about 0.75. 
     
     
         30 . The method of  claim 27 , wherein the dissolving step further comprises formulating the pharmaceutical solution with a baclofen concentration of up to about 2.0 mg/mL. 
     
     
         31 . The method of  claim 30 , wherein the baclofen concentration is about 0.5-2.0 mg/mL. 
     
     
         32 . The method of  claim 30 , wherein the baclofen concentration is about 0.5-1.0 mg/mL. 
     
     
         33 . The method of  claim 27 , further comprising dissolving a therapeutically effective dose of at least one of an anticonvulsant drug, an antispasmodic drug, an anticholinergic drug, or an antibiotic drug in the pharmaceutical solution.