Small molecules against cancer

Abstract

Compounds capable of, or usable in, killing cancer cells, and/or modulating a biological activity of a chemokine, and/or inhibiting a kinase, and/or treating diseases and disorders associated with a biological activity of a chemokine and/or cell migration, and/or treating disease and disorders such as cancer and inflammatory diseases and disorders, are provided herein. The compounds are listed in Tables 2, 4 and 5, and/or are represented by Formulae I, IV, V and VI, as defined in the specification. Methods utilizing these compounds are also provided.

What is claimed is: 
     
         1 . A method of treating an autoimmune disease in a subject in need thereof, the method comprising administering to the subject a compound represented by the Formula: 
       
         
           
           
               
               
           
         
         thereby treating the autoimmune disease. 
       
     
     
         2 . The method of  claim 1 , wherein said autoimmune disease is a cutaneous autoimmune disease. 
     
     
         3 . The method of  claim 3 , wherein said autoimmune cutaneous disease is selected from pemphigus vulgaris, bullous pemphigoid and pemphigus foliaceus. 
     
     
         4 . The method of  claim 1 , wherein said autoimmune disease is psoriasis. 
     
     
         5 . The method of  claim 1 , wherein the autoimmune disease is selected from an autoimmune cardiovascular disease, an autoimmune rheumatoid disease, an autoimmune glandular disease, an autoimmune gastrointestinal disease, an autoimmune hepatic disease, an autoimmune neurological disease, an autoimmune muscular disease, an autoimmune nephric disease, an autoimmune disease related to reproduction, an autoimmune connective tissue disease and an autoimmune systemic disease. 
     
     
         6 . The method of  claim 5 , wherein said autoimmune cardiovascular disease is selected from atherosclerosis, myocardial infarction, thrombosis, Wegener's granulomatosis, Takayasu's arteritis, Kawasaki syndrome, anti-factor VIII autoimmune disease, necrotizing small vessel vasculitis, microscopic polyangiitis, Churg and Strauss syndrome, pauci-immune focal necrotizing and crescentic glomerulonephritis, antiphospholipid syndrome, antibody-induced heart failure, thrombocytopenic purpura, autoimmune hemolytic anemia, cardiac autoimmunity in Chagas' disease and anti-helper T lymphocyte autoimmunity. 
     
     
         7 . The method of  claim 5 , wherein said autoimmune rheumatoid disease is selected from rheumatoid arthritis and ankylosing spondylitis. 
     
     
         8 . The method of  claim 5 , wherein said autoimmune glandular disease is selected from an autoimmune pancreatic disease, Type I diabetes, an autoimmune thyroid disease, Graves' disease, thyroiditis, spontaneous autoimmune thyroiditis, Hashimoto's thyroiditis, idiopathic myxedema, ovarian autoimmunity, autoimmune anti-sperm infertility, autoimmune prostatitis and Type I autoimmune polyglandular syndrome. 
     
     
         9 . The method of  claim 5 , wherein said autoimmune gastrointestinal disease is selected from a chronic inflammatory intestinal disease, celiac disease, colitis, ileitis and Crohn's disease. 
     
     
         10 . The method of  claim 5 , wherein said autoimmune hepatic disease is selected from autoimmune hepatitis, autoimmune chronic active hepatitis, and primary biliary cirrhosis. 
     
     
         11 . The method of  claim 5 , wherein said autoimmune neurological disease is selected from multiple, Alzheimer's disease, myasthenia gravis, an autoimmune neuropathy, myasthenia, Lambert-Eaton myasthenic syndrome, a paraneoplastic neurological disease, cerebellar atrophy, paraneoplastic cerebellar atrophy, stiff-man syndrome, a non-paraneoplastic stiff man syndrome, a progressive cerebellar atrophy, encephalitis, Rasmussen's encephalitis, amyotrophic lateral sclerosis, Sydeham chorea, Gilles de la Tourette syndrome, an autoimmune polyendocrinopathy, a dysimmune neuropathy, an acquired neuromyotonia, arthrogryposis multiplex congenita, neuritis, and optic neuritis. 
     
     
         12 . The method of  claim 5 , wherein said autoimmune neurological disease is a neurodegenerative disease. 
     
     
         13 . The method of  claim 5 , wherein said autoimmune muscular disease is selected from autoimmune myositis, primary Sjogren's syndrome and a smooth muscle autoimmune disease. 
     
     
         14 . The method of  claim 5 , wherein said autoimmune nephric disease is selected from nephritis and autoimmune interstitial nephritis. 
     
     
         15 . The method of  claim 5 , wherein said autoimmune disease related to reproduction is repeated fetal loss. 
     
     
         16 . The method of  claim 5 , wherein said autoimmune connective tissue disease is selected from an autoimmune ear disease and an autoimmune disease of the inner ear. 
     
     
         17 . The method of  claim 5 , wherein said autoimmune systemic disease is selected from systemic lupus erythematosus and systemic sclerosis. 
     
     
         18 . The method of  claim 1 , wherein said autoimmune disease is selected from Crohn's disease, psoriasis, scleroderma or rheumatoid arthritis.